DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14762 and 18w

DIOPT Version :9

Sequence 1:	NP_001246198.1	Gene:	CG14762 / 35768	FlyBaseID:	FBgn0033250	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	NP_476814.1	Gene:	18w / 37277	FlyBaseID:	FBgn0004364	Length:	1385	Species:	Drosophila melanogaster

Alignment Length:	340	Identity:	102/340 - (30%)
Similarity:	173/340 - (50%)	Gaps:	26/340 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 LKLRHNNLPKLQGFVFL---ALDIRHLT---IHNSSLAAIEE-----NALS------SLGAGLTQ 133
            |.|..||:.:|...|:.   :|.:.:||   |.::......|     :|||      |.|:.|..
  Fly   150 LHLGDNNIRQLPEGVWCSMPSLQLLNLTQNRIRSAEFLGFSEKLCAGSALSNANGAVSGGSELQT 214

  Fly   134 LDVSLNQMKTVP-SQALQHLFHLLILNLNHNKITVIHNNAFEGLETLEILTLYENKITQIDPEAF 197
            ||||.|:::::| :.....|..|..|:|.||.|:.:..||..||.:|.:|.:..|.:..:..|||
  Fly   215 LDVSFNELRSLPDAWGASRLRRLQTLSLQHNNISTLAPNALAGLSSLRVLNISYNHLVSLPSEAF 279

  Fly   198 RGLEDHIKRLNLGGNDLTNIPQKALSILSTLKKLEIQENKIRT--ISEGDFEGLQSLDSLILAHN 260
            .|.:: ::.|:|.||||..:|:..|..|..|..|::..|::.:  :....|.||..|..|.|::|
  Fly   280 AGNKE-LRELHLQGNDLYELPKGLLHRLEQLLVLDLSGNQLTSHHVDNSTFAGLIRLIVLNLSNN 343

  Fly   261 MITTVPANVFSHLTLLNSLELEGNKISVIDKDAFKGLEENLQYLRLGDNQIHTIPSEALRPLHRL 325
            .:|.:.:..|..|..|..|::..|.|..|::.||..| .||..|.|.:|::||:.:.....|:.|
  Fly   344 ALTRIGSKTFKELYFLQILDMRNNSIGHIEEGAFLPL-YNLHTLNLAENRLHTLDNRIFNGLYVL 407

  Fly   326 RHLDLRNNNINVLAEDAFTGFGDSLTFLNLQKNDIKVLPSLLFENLNSLETLNLQNNKLQRIPQD 390
            ..|.|.||.::::...||....| |..|:|..|.:..:|..: ::|:.|:||:|..|::.....:
  Fly   408 TKLTLNNNLVSIVESQAFRNCSD-LKELDLSSNQLTEVPEAV-QDLSMLKTLDLGENQISEFKNN 470

  Fly   391 IMEPV--IDTLRIID 403
            ....:  :..||:||
  Fly   471 TFRNLNQLTGLRLID 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14762	NP_001246198.1	leucine-rich repeat	85..105	CDD:275380	6/21 (29%)
		LRR_RI	93..384	CDD:238064	94/310 (30%)
		leucine-rich repeat	107..129	CDD:275380	8/35 (23%)
		leucine-rich repeat	131..154	CDD:275380	8/23 (35%)
		LRR_8	154..214	CDD:290566	21/59 (36%)
		leucine-rich repeat	155..178	CDD:275380	10/22 (45%)
		leucine-rich repeat	179..203	CDD:275380	7/23 (30%)
		leucine-rich repeat	204..227	CDD:275380	9/22 (41%)
		LRR_8	226..286	CDD:290566	16/61 (26%)
		leucine-rich repeat	228..251	CDD:275380	6/24 (25%)
		leucine-rich repeat	252..275	CDD:275380	7/22 (32%)
		LRR_8	276..335	CDD:290566	21/58 (36%)
		leucine-rich repeat	276..300	CDD:275380	8/23 (35%)
		leucine-rich repeat	301..324	CDD:275380	7/22 (32%)
		leucine-rich repeat	325..349	CDD:275380	7/23 (30%)
		LRR_8	349..409	CDD:290566	15/57 (26%)
		leucine-rich repeat	350..373	CDD:275380	6/22 (27%)
18w	NP_476814.1	leucine-rich repeat	66..91	CDD:275380
		leucine-rich repeat	92..115	CDD:275380
		LRR_8	115..181	CDD:290566	9/30 (30%)
		leucine-rich repeat	116..146	CDD:275380
		leucine-rich repeat	147..170	CDD:275380	6/19 (32%)
		leucine-rich repeat	171..201	CDD:275380	7/29 (24%)
		LRR_RI	210..464	CDD:238064	82/257 (32%)
		leucine-rich repeat	212..236	CDD:275380	8/23 (35%)
		LRR_8	235..295	CDD:290566	21/60 (35%)
		leucine-rich repeat	237..260	CDD:275380	10/22 (45%)
		leucine-rich repeat	261..284	CDD:275380	7/22 (32%)
		LRR_8	283..345	CDD:290566	19/62 (31%)
		leucine-rich repeat	285..308	CDD:275380	9/22 (41%)
		leucine-rich repeat	309..334	CDD:275380	6/24 (25%)
		LRR_8	334..393	CDD:290566	20/59 (34%)
		leucine-rich repeat	335..358	CDD:275380	7/22 (32%)
		leucine-rich repeat	359..382	CDD:275380	8/23 (35%)
		LRR_8	382..441	CDD:290566	20/59 (34%)
		leucine-rich repeat	383..406	CDD:275380	7/22 (32%)
		leucine-rich repeat	407..430	CDD:275380	7/22 (32%)
		LRR_8	431..488	CDD:290566	15/56 (27%)
		leucine-rich repeat	431..451	CDD:275380	5/20 (25%)
		leucine-rich repeat	454..477	CDD:275380	5/22 (23%)
		LRR_8	477..559	CDD:290566	4/9 (44%)
		leucine-rich repeat	478..499	CDD:275380	4/8 (50%)
		leucine-rich repeat	502..525	CDD:275380
		leucine-rich repeat	526..548	CDD:275380
		leucine-rich repeat	590..617	CDD:275380
		leucine-rich repeat	618..641	CDD:275380
		leucine-rich repeat	642..689	CDD:275380
		LRRCT	679..736	CDD:214507
		leucine-rich repeat	775..796	CDD:275380
		LRR_8	797..852	CDD:290566
		leucine-rich repeat	797..817	CDD:275380
		leucine-rich repeat	818..841	CDD:275380
		LRR_8	841..900	CDD:290566
		leucine-rich repeat	842..865	CDD:275380
		LRR_4	866..907	CDD:289563
		leucine-rich repeat	866..889	CDD:275380
		leucine-rich repeat	890..911	CDD:275380
		TIR	1045..1183	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45617
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010