Protein Alignment CG14762 and Slit2

DIOPT Version :10

• Sequence 1: NP_001246198.1
• Gene: CG14762 / 35768
• FlyBaseID: FBgn0033250
• Length: 498
• Species: Drosophila melanogaster
• Sequence 2: XP_038948069.1
• Gene: Slit2 / 360272
• RGDID: 69310
• Length: 1538
• Species: Rattus norvegicus
• Alignment Length: 601
• Identity: 149/601 - (24%)
• Similarity: 207/601 - (34%)
• Gaps: 213/601 - (35%)

  Fly     1 MAGIQLQSGCTMVVTVVLLLQVLVMDQVLGQGPPQTQVCPEQSEIAPCICTVKKNGLDILCETTD 65
            |:||..|   |:.:::.|:|.:|  :||      ..|.||.|     |.|    :|..:.|
  Rat     1 MSGIGWQ---TLSLSLALVLSIL--NQV------APQACPAQ-----CSC----SGSTVDC---- 41

  Fly    66 LAHITKSMGTLKGKSPIIFYLKLRHNNLPKLQGFVFLALDIRHLTIHNSSLAAIEENALSSLGAG 130
                                                          |..:|.::..|    :...
  Rat    42 ----------------------------------------------HGLALRSVPRN----IPRN 56

  Fly   131 LTQLDVSLNQMKTVPSQALQHLFHLLILNLNHNKITVIHNNAFEGLETLEILTLYENKITQIDPE 195
            ..:||::.|.:..:.......|.||.:|.|..|||:.|...||:.|:.||.|.|..|.: |:.||
  Rat    57 TERLDLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNNL-QLFPE 120

  Fly   196 -AFRGLEDHIKRLNLGGNDLTNIPQKALSILSTLKKLEIQENKIRTISEGDFEGLQSLDSLILAH 259
             .|.|.. .:.||:|..|.:..||:||......:|.|::..|:|..|.:|.|..|:.|:.|.|.:
  Rat   121 LLFLGTA-KLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNN 184

  Fly   260 NMITTVPANVFSHLTLL-------NSL-----------------------------ELEGNKISV 288
            |.||.:....|:|:..|       |:|                             .|.|:.::.
  Rat   185 NNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPSHLRGHNVAE 249

  Fly   289 IDKDAF---------------------------------KG-------LEENLQYLRLGDNQIHT 313
            :.|..|                                 ||       |.|.:..:||..|.|..
  Rat   250 VQKREFVCSGHQSFMAPSCSVLHCPIACTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQNSIRV 314

  Fly   314 IPSEALRPLHRLRHLDLRNNNINVLAEDAFTGFGDSLTFLNLQKNDIKVLPSLLFENLNSLETLN 378
            ||..|..|..:||.|||.||.|:.||.|||.|. .||..|.|..|.|..||..|||.|.||:.|.
  Rat   315 IPPGAFSPYKKLRRLDLSNNQISELAPDAFQGL-RSLNSLVLYGNKITELPKSLFEGLFSLQLLL 378

  Fly   379 LQNNKLQ--RIP------------------QDIMEPVIDTLRIID---ITDNPLNCSCELTWFPK 420
            |..||:.  |:.                  |.:.:.....||.|.   :..||..|.|.|.|...
  Rat   379 LNANKINCLRVDAFQDLHNLNLLSLYDNKLQTVAKGTFSALRAIQTMHLAQNPFICDCHLKWLAD 443

  Fly   421 LLED---------------LKNKDDEMSQKKKPLCHMSLDNREYFVQ-----------------A 453
            .|..               |.||.....:.||..|..   ..:||:.                 |
  Rat   444 YLHTNPIETSGARCTSPRRLANKRIGQIKSKKFRCSA---KEQYFIPGTEDYRSKLSGDCFADLA 505

  Fly   454 MPTEKMHCAGLNVSPS 469
            .| ||..|.|..|..|
  Rat   506 CP-EKCRCEGTTVDCS 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14762	NP_001246198.1	leucine-rich repeat	85..105	CDD:275380	0/19 (0%)
		leucine-rich repeat	107..129	CDD:275380	3/21 (14%)
		LRR	<131..410	CDD:443914	107/378 (28%)
		leucine-rich repeat	131..154	CDD:275380	4/22 (18%)
		leucine-rich repeat	155..178	CDD:275380	10/22 (45%)
		leucine-rich repeat	179..203	CDD:275380	10/24 (42%)
		leucine-rich repeat	204..227	CDD:275380	8/22 (36%)
		leucine-rich repeat	228..251	CDD:275380	8/22 (36%)
		leucine-rich repeat	252..275	CDD:275380	8/22 (36%)
		leucine-rich repeat	276..300	CDD:275380	10/99 (10%)
		leucine-rich repeat	301..324	CDD:275380	8/22 (36%)
		leucine-rich repeat	325..349	CDD:275380	14/23 (61%)
		leucine-rich repeat	350..373	CDD:275380	11/22 (50%)
Slit2	XP_038948069.1	LRRNT	27..58	CDD:214470	10/93 (11%)
		leucine-rich repeat	38..56	CDD:275380	4/71 (6%)
		LRR	<56..>211	CDD:443914	51/156 (33%)
		leucine-rich repeat	57..80	CDD:275380	4/22 (18%)
		leucine-rich repeat	81..104	CDD:275380	10/22 (45%)
		leucine-rich repeat	105..128	CDD:275380	10/24 (42%)
		leucine-rich repeat	129..152	CDD:275380	8/22 (36%)
		leucine-rich repeat	153..176	CDD:275380	8/22 (36%)
		leucine-rich repeat	177..200	CDD:275380	8/22 (36%)
		PCC	182..>319	CDD:188093	23/136 (17%)
		leucine-rich repeat	201..325	CDD:275380	19/123 (15%)
		LRR	<302..667	CDD:443914	68/224 (30%)
		leucine-rich repeat	326..349	CDD:275380	14/23 (61%)
		leucine-rich repeat	350..370	CDD:275380	9/19 (47%)
		leucine-rich repeat	374..397	CDD:275380	6/22 (27%)
		leucine-rich repeat	398..419	CDD:275380	1/20 (5%)
		leucine-rich repeat	422..523	CDD:275380	24/103 (23%)
		leucine-rich repeat	537..559	CDD:275380
		leucine-rich repeat	560..583	CDD:275380
		LRR	564..>861	CDD:443914
		leucine-rich repeat	584..607	CDD:275380
		leucine-rich repeat	608..631	CDD:275380
		leucine-rich repeat	632..655	CDD:275380
		leucine-rich repeat	656..747	CDD:275380
		leucine-rich repeat	748..778	CDD:275380
		leucine-rich repeat	779..802	CDD:275380
		leucine-rich repeat	803..826	CDD:275380
		leucine-rich repeat	827..848	CDD:275380
		PCC	832..>1013	CDD:188093
		leucine-rich repeat	851..863	CDD:275378
		EGF	1002..1029	CDD:394967
		EGF_CA	1047..1082	CDD:238011
		EGF_CA	1085..1121	CDD:238011
		LamG	1192..1325	CDD:214598