Protein Alignment CG14762 and LRRTM3

DIOPT Version :10

• Sequence 1: NP_001246198.1
• Gene: CG14762 / 35768
• FlyBaseID: FBgn0033250
• Length: 498
• Species: Drosophila melanogaster
• Sequence 2: NP_821079.3
• Gene: LRRTM3 / 347731
• HGNCID: 19410
• Length: 581
• Species: Homo sapiens
• Alignment Length: 476
• Identity: 124/476 - (26%)
• Similarity: 193/476 - (40%)
• Gaps: 129/476 - (27%)

  Fly     4 IQLQSG--CTMVVTVVLLLQVLVMDQVLGQGPPQTQVCPEQSEIAPCICTVKKNGLDILCETTDL 66
            |:|.||  ..:|:...:||.:|...:         :.||:     .|.|    .|..:.||:..|
Human     6 IRLLSGSAVALVIAPTVLLTMLSSAE---------RGCPK-----GCRC----EGKMVYCESQKL 52

  Fly    67 AHITKSM--GTLKGKSPIIFYLKLRHNNLPKLQGFVFLALD-IRHLTIHNSSLAAIEENALSSLG 128
            ..|..|:  |.|.        |.||:|:|.||:...|..|: :..|.:.::.::.|:|||.:.:
Human    53 QEIPSSISAGCLG--------LSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGI- 108

  Fly   129 AGLTQLDVSLNQMKTVPSQALQHLFHLLILNLNHNKITVIHNNAFEGLETLEILTLYENKITQID 193
                              :.|:.|.      |:.|:|:...||.|..:..|..|.|..|::..:.
Human   109 ------------------RRLKELI------LSSNRISYFLNNTFRPVTNLRNLDLSYNQLHSLG 149

  Fly   194 PEAFRGLEDHIKRLNLGGNDLTNIPQKALSILSTLKKLEIQENKIRTISEGDFEGLQSLDSLILA 258
            .|.||||. .:..|:|..|.|..||.:.......|:.|::..|:||:::...|.|:..|..|.|.
Human   150 SEQFRGLR-KLLSLHLRSNSLRTIPVRIFQDCRNLELLDLGYNRIRSLARNVFAGMIRLKELHLE 213

  Fly   259 HNMITTVPANVFSHLTLLNSLELEGNKISVIDKDAFKGLEENLQYLRLGDNQIHTIPSEALRPLH 323
            ||..:.:...:|..|..|.:|.|:.||||||                 |.....|..|
Human   214 HNQFSKLNLALFPRLVSLQNLYLQWNKISVI-----------------GQTMSWTWSS------- 254

  Fly   324 RLRHLDLRNNNINVLAEDAFTGFGDSLTFLNLQKNDIKVLPSLLFENLNSLETLNLQNNKLQRIP 388
             |:.|||..|.|     :||:|                  || :|:.:.:|:.|||.:|||..|.
Human   255 -LQRLDLSGNEI-----EAFSG------------------PS-VFQCVPNLQRLNLDSNKLTFIG 294

  Fly   389 QDIMEPVIDTLRIIDITDNPLNCS---CEL-TWF---------------PKLLEDLKNKDDEMSQ 434
            |:|::..| :|..|.:..|...||   |.| .|.               ||.|:.:...|   :.
Human   295 QEILDSWI-SLNDISLAGNIWECSRNICSLVNWLKSFKGLRENTIICASPKELQGVNVID---AV 355

  Fly   435 KKKPLCHMSLDNREYFVQAMP 455
            |...:|..|...|....:|:|
Human   356 KNYSICGKSTTERFDLARALP 376

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14762	NP_001246198.1	leucine-rich repeat	85..105	CDD:275380	8/19 (42%)
		leucine-rich repeat	107..129	CDD:275380	5/21 (24%)
		LRR	<131..410	CDD:443914	75/278 (27%)
		leucine-rich repeat	131..154	CDD:275380	2/22 (9%)
		leucine-rich repeat	155..178	CDD:275380	6/22 (27%)
		leucine-rich repeat	179..203	CDD:275380	9/23 (39%)
		leucine-rich repeat	204..227	CDD:275380	6/22 (27%)
		leucine-rich repeat	228..251	CDD:275380	7/22 (32%)
		leucine-rich repeat	252..275	CDD:275380	7/22 (32%)
		leucine-rich repeat	276..300	CDD:275380	9/23 (39%)
		leucine-rich repeat	301..324	CDD:275380	3/22 (14%)
		leucine-rich repeat	325..349	CDD:275380	9/23 (39%)
		leucine-rich repeat	350..373	CDD:275380	3/22 (14%)
LRRTM3	NP_821079.3	LRRNT	33..61	CDD:214470	10/36 (28%)
		LRR	59..339	CDD:443914	96/363 (26%)
		LRR 1	63..83		9/27 (33%)
		leucine-rich repeat	66..86	CDD:275380	9/19 (47%)
		LRR 2	86..107		5/20 (25%)
		leucine-rich repeat	87..110	CDD:275380	5/41 (12%)
		LRR 3	110..131		8/26 (31%)
		leucine-rich repeat	111..134	CDD:275380	8/28 (29%)
		LRR 4	134..155		6/20 (30%)
		leucine-rich repeat	135..158	CDD:275380	9/23 (39%)
		LRR 5	158..179		6/20 (30%)
		leucine-rich repeat	159..182	CDD:275380	6/22 (27%)
		LRR 6	182..203		6/20 (30%)
		leucine-rich repeat	183..206	CDD:275380	7/22 (32%)
		LRR 7	206..226		5/19 (26%)
		leucine-rich repeat	207..230	CDD:275380	7/22 (32%)
		LRR 8	230..251		10/37 (27%)
		leucine-rich repeat	231..254	CDD:275380	11/39 (28%)
		LRR 9	254..275		12/52 (23%)
		leucine-rich repeat	255..279	CDD:275380	12/47 (26%)
		LRR 10	279..300		10/20 (50%)
		leucine-rich repeat	280..300	CDD:275380	10/19 (53%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	377..408		124/476 (26%)