DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14762 and haf

DIOPT Version :9

Sequence 1:	NP_001246198.1	Gene:	CG14762 / 35768	FlyBaseID:	FBgn0033250	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	NP_001356954.1	Gene:	haf / 33339	FlyBaseID:	FBgn0261509	Length:	1347	Species:	Drosophila melanogaster

Alignment Length:	476	Identity:	127/476 - (26%)
Similarity:	207/476 - (43%)	Gaps:	80/476 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 VLVMDQVLGQGPPQTQVCPEQSEI----APCICTVK-KNGLDILCETTDLAHITKSMGTLKGKSP 81
            :|::..:||:.......||.|.::    ..|||... ...|.:.|:..|.:.:..:|.|.....|
  Fly    18 LLLLPLILGRLHVAHAQCPWQRDVPDLQTSCICAYNLGRELSVQCDQVDFSQLLAAMNTHARLKP 82

  Fly    82 IIFYLKLRHNNLPKLQGFVFLALDIRHLTIHNSSLAAIEENALSSLGAGLTQLDVSLNQMKTVPS 146
            :.. |.:.::.:.:|...||..|.:.:|.:.:..:..|...|.....:.|..|::..|.:..||.
  Fly    83 VDL-LYVNNSTISELPDAVFSNLSLHNLQLSSCGIQRIATGAFKGQESVLRNLNLQDNLLADVPV 146

  Fly   147 QALQHLFHLLILNLNHNKITVIHNNAFEGLETLEILTLYENKITQIDPEAFRGLEDHIKRLNLGG 211
            :||:.|..|.:|:|:.|:::.|.::||.||..|..|.|.:|.:| :...||||||..:|.|||.|
  Fly   147 EALKVLGKLNLLDLSKNQLSHIPDDAFVGLTKLSTLKLNDNNVT-LASNAFRGLEQSLKNLNLKG 210

  Fly   212 NDLTNIPQKALSILSTLKKLEIQENKIRTISEGDFEGLQSLDSLILAHNMITTVPA----NVFSH 272
            .....:|:                         ...||:||..|.|:.|.|..:|.    .||..
  Fly   211 TKQRKVPE-------------------------SIRGLKSLAFLDLSQNGIKELPGAGGIRVFDG 250

  Fly   273 LTLLNSLELEGNKISVIDKDAFKGLEENLQYLRLGDNQIHTIPSEALRPLHRLRHLDLRNNNINV 337
            |..|.:|.||.|.|..|.:.||.|:.:.|..|.|.:|.:...|..|:..|..||.||:..|.:..
  Fly   251 LDALTALNLERNLIQSIGETAFAGVRKTLSSLSLLNNLLAEFPIGAVHSLKELRVLDIGFNLLTS 315

  Fly   338 LAEDAFTGFGDSLTFLNLQKNDIKVLPSLLFENLNSLETLNLQNNKLQRIPQDIMEPVIDTLRII 402
            |.|.||.| ...:|.|.|..|.:..:|...|.:||:                        |||.:
  Fly   316 LPEAAFRG-NPGITLLALDGNPLSSVPEGAFAHLNA------------------------TLRGL 355

  Fly   403 DITDNPLNCSCELTWFPKLLEDLKNKDDEM-SQKKKP-LCHMSLDNREYFVQAMPTEKMHC---- 461
            .:....|:|.|:|.|   :.|.::|.|.:: |:::.| .|......|:....::..|::.|
  Fly   356 SLGGRFLHCDCKLRW---VAEWIRNGDLQVTSRERNPQFCGTPPRFRDRGFYSIQPEELSCPDIA 417

  Fly   462 -------AGL--NVSPS-PTS 472
                   .||  |:.|: |:|
  Fly   418 DAALRGPVGLADNLKPTLPSS 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14762	NP_001246198.1	leucine-rich repeat	85..105	CDD:275380	4/19 (21%)
		LRR_RI	93..384	CDD:238064	88/294 (30%)
		leucine-rich repeat	107..129	CDD:275380	3/21 (14%)
		leucine-rich repeat	131..154	CDD:275380	8/22 (36%)
		LRR_8	154..214	CDD:290566	25/59 (42%)
		leucine-rich repeat	155..178	CDD:275380	9/22 (41%)
		leucine-rich repeat	179..203	CDD:275380	11/23 (48%)
		leucine-rich repeat	204..227	CDD:275380	6/22 (27%)
		LRR_8	226..286	CDD:290566	17/63 (27%)
		leucine-rich repeat	228..251	CDD:275380	2/22 (9%)
		leucine-rich repeat	252..275	CDD:275380	9/26 (35%)
		LRR_8	276..335	CDD:290566	22/58 (38%)
		leucine-rich repeat	276..300	CDD:275380	10/23 (43%)
		leucine-rich repeat	301..324	CDD:275380	7/22 (32%)
		leucine-rich repeat	325..349	CDD:275380	10/23 (43%)
		LRR_8	349..409	CDD:290566	11/59 (19%)
		leucine-rich repeat	350..373	CDD:275380	7/22 (32%)
haf	NP_001356954.1	LRR	<52..>252	CDD:227223	59/226 (26%)
		leucine-rich repeat	86..105	CDD:275380	4/18 (22%)
		leucine-rich repeat	106..129	CDD:275380	3/22 (14%)
		LRR_8	131..189	CDD:338972	21/57 (37%)
		leucine-rich repeat	131..154	CDD:275380	8/22 (36%)
		leucine-rich repeat	155..178	CDD:275380	9/22 (41%)
		leucine-rich repeat	179..202	CDD:275380	11/23 (48%)
		leucine-rich repeat	203..225	CDD:275380	8/46 (17%)
		leucine-rich repeat	226..253	CDD:275380	9/26 (35%)
		LRR_8	254..337	CDD:338972	31/83 (37%)
		leucine-rich repeat	254..302	CDD:275380	17/47 (36%)
		leucine-rich repeat	303..326	CDD:275380	10/23 (43%)
		leucine-rich repeat	327..350	CDD:275380	7/22 (32%)
		PCC	332..>413	CDD:188093	22/107 (21%)
		PRK10927	<1061..>1097	CDD:236797
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910