DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14762 and Lingo1

DIOPT Version :9

Sequence 1:	NP_001246198.1	Gene:	CG14762 / 35768	FlyBaseID:	FBgn0033250	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	NP_001094192.1	Gene:	Lingo1 / 315691	RGDID:	1308668	Length:	620	Species:	Rattus norvegicus

Alignment Length:	398	Identity:	105/398 - (26%)
Similarity:	174/398 - (43%)	Gaps:	48/398 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 VLVMDQVLGQGPPQTQVCPEQSEIAPCICTVKKNGLDILCETTDLAHITKSMGTLKGKSPIIFYL 86
            :||:..||.   .....||.:     |.|:.:...  :||      |..:.:...:|.......|
  Rat    28 LLVLGSVLS---GSATGCPPR-----CECSAQDRA--VLC------HRKRFVAVPEGIPTETRLL 76

  Fly    87 KLRHNNLPKLQGFVFLAL-DIRHLTIHNSSLAAIEENALSSLGAGLTQLDVSLNQMKTVPSQALQ 150
            .|..|.:..|....|.:. .:..|.::.:.::|:|..|.::| ..|..|.:..|::|.:|.....
  Rat    77 DLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNL-FNLRTLGLRSNRLKLIPLGVFT 140

  Fly   151 HLFHLLILNLNHNKITVIHNNAFEGLETLEILTLYENKITQIDPEAFRGLEDHIKRLNLGGNDLT 215
            .|.:|..|:::.|||.::.:..|:.|..|:.|.:.:|.:..|...||.|| :.:::|.|...:||
  Rat   141 GLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGL-NSLEQLTLEKCNLT 204

  Fly   216 NIPQKALSILSTLKKLEIQENKIRTISEGDFEGLQSLDSLILAH-NMITTVPANVFSHLTLLNSL 279
            :||.:|||.|..|..|.::...|..|.:..|:.|..|..|.::| ..:.|:..|....|. |.||
  Rat   205 SIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGLN-LTSL 268

  Fly   280 ELEGNKISVIDKDAFKGLEENLQYLRLGDNQIHTIPSEALRPLHRLRHLDLRNNNINVLAEDAFT 344
            .:....::.:...|.:.| ..|::|.|..|.|.||....|..|.||:.:.|....:.|:...||.
  Rat   269 SITHCNLTAVPYLAVRHL-VYLRFLNLSYNPIGTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFR 332

  Fly   345 GFGDSLTFLNLQKNDIKVLPSLLFENLNSLETLNLQNNKLQRIPQDIMEPVIDTLRIIDITDNPL 409
            |. :.|..||:..|.:..|....|.::.:||||                       |:|  .|||
  Rat   333 GL-NYLRVLNVSGNQLTTLEESAFHSVGNLETL-----------------------ILD--SNPL 371

  Fly   410 NCSCELTW 417
            .|.|.|.|
  Rat   372 ACDCRLLW 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14762	NP_001246198.1	leucine-rich repeat	85..105	CDD:275380	5/20 (25%)
		LRR_RI	93..384	CDD:238064	81/292 (28%)
		leucine-rich repeat	107..129	CDD:275380	5/21 (24%)
		leucine-rich repeat	131..154	CDD:275380	6/22 (27%)
		LRR_8	154..214	CDD:290566	17/59 (29%)
		leucine-rich repeat	155..178	CDD:275380	7/22 (32%)
		leucine-rich repeat	179..203	CDD:275380	8/23 (35%)
		leucine-rich repeat	204..227	CDD:275380	10/22 (45%)
		LRR_8	226..286	CDD:290566	15/60 (25%)
		leucine-rich repeat	228..251	CDD:275380	6/22 (27%)
		leucine-rich repeat	252..275	CDD:275380	6/23 (26%)
		LRR_8	276..335	CDD:290566	17/58 (29%)
		leucine-rich repeat	276..300	CDD:275380	5/23 (22%)
		leucine-rich repeat	301..324	CDD:275380	9/22 (41%)
		leucine-rich repeat	325..349	CDD:275380	6/23 (26%)
		LRR_8	349..409	CDD:290566	13/59 (22%)
		leucine-rich repeat	350..373	CDD:275380	6/22 (27%)
Lingo1	NP_001094192.1	LRRNT	41..75	CDD:214470	8/46 (17%)
		LRR	<66..371	CDD:227223	88/334 (26%)
		leucine-rich repeat	73..96	CDD:275380	5/22 (23%)
		leucine-rich repeat	97..120	CDD:275380	5/23 (22%)
		LRR_8	120..179	CDD:404697	16/58 (28%)
		leucine-rich repeat	121..144	CDD:275380	6/22 (27%)
		leucine-rich repeat	145..192	CDD:275380	15/47 (32%)
		leucine-rich repeat	193..216	CDD:275380	10/22 (45%)
		leucine-rich repeat	217..264	CDD:275380	11/46 (24%)
		leucine-rich repeat	265..288	CDD:275380	5/23 (22%)
		leucine-rich repeat	289..312	CDD:275380	9/22 (41%)
		leucine-rich repeat	313..336	CDD:275380	6/23 (26%)
		leucine-rich repeat	337..357	CDD:275380	6/19 (32%)
		PCC	341..>421	CDD:188093	17/64 (27%)
		IgI_Lingo-1	423..514	CDD:409561
		Ig strand B	442..446	CDD:409561
		Ig strand C	455..459	CDD:409561
		Ig strand E	480..484	CDD:409561
		Ig strand F	494..499	CDD:409561
		Ig strand G	507..510	CDD:409561
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910