DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14762 and Nyx

DIOPT Version :9

Sequence 1:	NP_001246198.1	Gene:	CG14762 / 35768	FlyBaseID:	FBgn0033250	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	NP_001094437.1	Gene:	Nyx / 302516	RGDID:	1561300	Length:	476	Species:	Rattus norvegicus

Alignment Length:	388	Identity:	98/388 - (25%)
Similarity:	160/388 - (41%)	Gaps:	65/388 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 QVCPEQSEIAPCICTVKKNGLDILCETTDLAHITKSMGTLKGKSPIIFYLKLRHNNLPKLQGFVF 101
            :.||     |.|.|:..:.|..:.|:...|..:           |..|..:.
  Rat    24 RACP-----AACTCSNVERGCSVRCDRAGLQRV-----------PTEFPCEA------------- 59

  Fly   102 LALDIRHLTIHNSSLAAIEENALSSLGAGLTQLDVSLNQMKTVPSQALQHLFHLLILNLNHNKIT 166
            .::|             ::.|.|..||.         ....|:||        |..|:|.||.::
  Rat    60 ASID-------------LDRNGLRILGE---------RAFGTLPS--------LRCLSLRHNNLS 94

  Fly   167 VIHNNAFEGLETLEILTLYEN-KITQIDPEAFRGLEDHIKRLNLGGNDLTNIPQKALSILSTLKK 230
            .|...||:||..|..|.|..| ::..:....|..| ..::||:|....|.::|::.|:.|..|::
  Rat    95 FITPGAFKGLPRLAELRLAHNGELRYLHVRTFAAL-GRLRRLDLAACRLFSVPERLLAELPALRE 158

  Fly   231 LEIQENKIRTISEGDFEGLQSLDSLILAHNMITTVPANVFSHLTLLNSLELEGNKISVIDKDAFK 295
            |...:|..|.: .|...||.:|.......:.|..|.::....:..|.||.|:.|::..:...||
  Rat   159 LTAFDNLFRRV-PGALRGLANLTHAHFERSRIEAVASSSLLGMRRLRSLSLQANRVRAVHAGAF- 221

  Fly   296 GLEENLQYLRLGDNQIHTIPSEALRPLHRLRHLDLRNNNINVLAEDAFTGFGDSLTFLNLQKNDI 360
            |....|::|.|.||.:.::|:.|.|.|.|||.|:|..|.:..:|...|:...: |..|.|.:|.|
  Rat   222 GDCVALEHLLLNDNLLASLPAAAFRGLRRLRTLNLGGNALGSVARGWFSDLAE-LELLYLDRNSI 285

  Fly   361 KVLPSLLFENLNSLETLNLQNNKLQRIPQDIMEPVIDTLRIIDITDNPLNCSCELTWFPKLLE 423
            ..:....|:||:.|..|:|..|:|..:.....:|.....|:. :..||..|.|.|.|....:|
  Rat   286 TFVEEGAFQNLSGLLALHLNGNRLTVLSWAAFQPGFFLGRLF-LFRNPWRCDCHLEWLRDWME 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14762	NP_001246198.1	leucine-rich repeat	85..105	CDD:275380	0/19 (0%)
		LRR_RI	93..384	CDD:238064	78/291 (27%)
		leucine-rich repeat	107..129	CDD:275380	3/21 (14%)
		leucine-rich repeat	131..154	CDD:275380	3/22 (14%)
		LRR_8	154..214	CDD:290566	19/60 (32%)
		leucine-rich repeat	155..178	CDD:275380	10/22 (45%)
		leucine-rich repeat	179..203	CDD:275380	6/24 (25%)
		leucine-rich repeat	204..227	CDD:275380	7/22 (32%)
		LRR_8	226..286	CDD:290566	15/59 (25%)
		leucine-rich repeat	228..251	CDD:275380	7/22 (32%)
		leucine-rich repeat	252..275	CDD:275380	3/22 (14%)
		LRR_8	276..335	CDD:290566	23/58 (40%)
		leucine-rich repeat	276..300	CDD:275380	8/23 (35%)
		leucine-rich repeat	301..324	CDD:275380	9/22 (41%)
		leucine-rich repeat	325..349	CDD:275380	7/23 (30%)
		LRR_8	349..409	CDD:290566	16/59 (27%)
		leucine-rich repeat	350..373	CDD:275380	8/22 (36%)
Nyx	NP_001094437.1	LRRNT	25..56	CDD:214470	9/46 (20%)
		leucine-rich repeat	63..82	CDD:275380	6/40 (15%)
		LRR_RI	<68..312	CDD:238064	77/264 (29%)
		LRR_8	81..142	CDD:290566	21/69 (30%)
		leucine-rich repeat	83..106	CDD:275380	10/22 (45%)
		leucine-rich repeat	107..131	CDD:275380	6/24 (25%)
		leucine-rich repeat	132..155	CDD:275380	7/22 (32%)
		leucine-rich repeat	156..178	CDD:275380	7/22 (32%)
		leucine-rich repeat	179..202	CDD:275380	3/22 (14%)
		LRR_8	201..261	CDD:290566	23/60 (38%)
		leucine-rich repeat	203..226	CDD:275380	8/23 (35%)
		leucine-rich repeat	227..250	CDD:275380	9/22 (41%)
		LRR_8	249..309	CDD:290566	20/60 (33%)
		leucine-rich repeat	251..274	CDD:275380	7/22 (32%)
		leucine-rich repeat	275..296	CDD:275380	6/20 (30%)
		leucine-rich repeat	299..318	CDD:275380	5/18 (28%)
		LRRCT	331..>366	CDD:214507	7/17 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D277227at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920