DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14762 and Slitrk6

DIOPT Version :9

Sequence 1:	NP_001246198.1	Gene:	CG14762 / 35768	FlyBaseID:	FBgn0033250	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	NP_001099527.1	Gene:	Slitrk6 / 290467	RGDID:	1306550	Length:	840	Species:	Rattus norvegicus

Alignment Length:	645	Identity:	157/645 - (24%)
Similarity:	222/645 - (34%)	Gaps:	235/645 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 PQTQVC---PEQSEIAP--------CICTVKKNGLDILCETTDLAHITKSMGTLKGKS-----PI 82
            |....|   ..||.:.|        |.|..|...:.|.||       .|.:.||...|     |
  Rat    10 PSLLACLSLQSQSPMPPVRGSCDTLCTCEEKDGIMIINCE-------EKGINTLSQISVPPSRP- 66

  Fly    83 IFYLKLRHNNLPKLQGFVFL----ALDIRHLTIHNSSLAAIEENALSSLGAGLTQLDVSLNQMKT 143
             |:|.|.:|.|..|....|.    ||.| ||..:|  :|.||..|.:.||. |.||.::.|.::.
  Rat    67 -FHLSLLNNGLTTLHTNDFSGLTNALSI-HLGFNN--IADIETGAFNGLGL-LKQLHINHNSLEI 126

  Fly   144 VPSQALQHLFHLLILNLNHNKITVIHNNAFEGLETLEILTLYENKITQIDPEAFR---------- 198
            :.......|.:|..|..::|.||||..:||..|..|::|.|.:|.|..:.|..||
  Rat   127 LKEDTFHGLENLEFLQADNNFITVIEQSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLTHLDLR 191

  Fly   199 ----------GLEDHIKR---LNLGGND-------------LTNIPQKAL--------------S 223
                      |..:||.|   |.|..|.             |.|:|.:::              |
  Rat   192 GNQLQTLPYVGFLEHIGRILDLQLEDNKWACNCELLQLKNWLENMPPQSIIGDVICYSPPLFKGS 256

  Fly   224 ILSTLKK---------------------------------------------------------- 230
            |||.|||
  Rat   257 ILSRLKKESICPTPPVYEEHEDPAGSLLAITSSTSDSRLSSKNTSILKQPTKAPGSVPYLTKPST 321

  Fly   231 ----------------------LEIQE-----------------------NKIRTISEGDFEGLQ 250
                                  :..||                       |.|.|:.:.|.....
  Rat   322 QLPVPYCPVPCNCKVLSPSGLLIHCQERNIESVSDLQPPPHNPRKLILAGNIIHTLMKADLMDYF 386

  Fly   251 SLDSLILAHNMITTVPANVFSHLTLLNSLELEGNKISVIDKDAFKGLEENLQYLRLGDNQIHTIP 315
            :|:.|.|.:|.|..:....|.:||.|..|.|.||.::.:.|..|.|| .:|:||.|..|.:..|.
  Rat   387 TLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLYKGMFLGL-SSLEYLYLEYNAVKEIL 450

  Fly   316 SEALRPLHRLRHLDLRNNNINVLAEDAFTGFGDSLTFLNLQKNDIKVLPSLLFENLNSLETLNLQ 380
            .....|:.:|:.|.|.||.::||....|.|.  .||.:||:.|....||
  Rat   451 PGTFNPMPKLKVLYLNNNLLHVLPAHIFLGI--PLTRVNLKTNQFTHLP---------------- 497

  Fly   381 NNKLQRIPQDIMEPVIDTLRIIDITDNPLNCSCELT----WFPKLLEDLKNKDDEMSQKKKPLC- 440
               :..|..|     :|.|..||:.|||.:|||:|.    |..||.:.....|        .||
  Rat   498 ---VSNILDD-----LDLLIQIDLEDNPWDCSCDLVGLQQWIHKLGKGTVTDD--------ILCA 546

  Fly   441 ---HMSLDNREYFVQAMPTEKMHCAGLNVSPS-PTSGGLMRILQVNILAQIAVCSVAFLT 496
               |  ||.:|  ::|:.:|.: |.||..:|| ||....:.:....:.|..|...::.||
  Rat   547 SPGH--LDKKE--LKALNSELL-CPGLVNNPSMPTQTSYIIVTSPTMAADAAGTLLSSLT 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14762	NP_001246198.1	leucine-rich repeat	85..105	CDD:275380	7/23 (30%)
		LRR_RI	93..384	CDD:238064	101/447 (23%)
		leucine-rich repeat	107..129	CDD:275380	8/21 (38%)
		leucine-rich repeat	131..154	CDD:275380	5/22 (23%)
		LRR_8	154..214	CDD:290566	25/95 (26%)
		leucine-rich repeat	155..178	CDD:275380	10/22 (45%)
		leucine-rich repeat	179..203	CDD:275380	9/43 (21%)
		leucine-rich repeat	204..227	CDD:275380	11/52 (21%)
		LRR_8	226..286	CDD:290566	23/162 (14%)
		leucine-rich repeat	228..251	CDD:275380	9/125 (7%)
		leucine-rich repeat	252..275	CDD:275380	7/22 (32%)
		LRR_8	276..335	CDD:290566	21/58 (36%)
		leucine-rich repeat	276..300	CDD:275380	9/23 (39%)
		leucine-rich repeat	301..324	CDD:275380	7/22 (32%)
		leucine-rich repeat	325..349	CDD:275380	9/23 (39%)
		LRR_8	349..409	CDD:290566	15/59 (25%)
		leucine-rich repeat	350..373	CDD:275380	7/22 (32%)
Slitrk6	NP_001099527.1	leucine-rich repeat	68..89	CDD:275380	6/20 (30%)
		LRR_8	69..124	CDD:290566	22/58 (38%)
		leucine-rich repeat	94..113	CDD:275380	8/20 (40%)
		leucine-rich repeat	114..137	CDD:275380	5/22 (23%)
		LRR_8	137..195	CDD:290566	18/57 (32%)
		leucine-rich repeat	138..161	CDD:275380	10/22 (45%)
		leucine-rich repeat	162..177	CDD:275380	5/14 (36%)
		leucine-rich repeat	185..260	CDD:275380	13/74 (18%)
		leucine-rich repeat	210..222	CDD:275378	3/11 (27%)
		TPKR_C2	218..268	CDD:301599	11/49 (22%)
		leucine-rich repeat	261..411	CDD:275380	16/149 (11%)
		leucine-rich repeat	365..387	CDD:275380	4/21 (19%)
		LRR_8	387..444	CDD:290566	21/57 (37%)
		LRR_4	388..425	CDD:289563	13/36 (36%)
		LRR_4	410..449	CDD:289563	15/39 (38%)
		leucine-rich repeat	412..435	CDD:275380	9/23 (39%)
		LRR_8	434..493	CDD:290566	21/60 (35%)
		leucine-rich repeat	436..459	CDD:275380	7/22 (32%)
		leucine-rich repeat	460..481	CDD:275380	8/20 (40%)
		LRRCT	516..566	CDD:214507	18/62 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000