DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG14762 and SLITRK5

DIOPT Version :9

Sequence 1:NP_001246198.1 Gene:CG14762 / 35768 FlyBaseID:FBgn0033250 Length:498 Species:Drosophila melanogaster
Sequence 2:NP_001371538.1 Gene:SLITRK5 / 26050 HGNCID:20295 Length:958 Species:Homo sapiens


Alignment Length:675 Identity:142/675 - (21%)
Similarity:213/675 - (31%) Gaps:272/675 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly    48 CICTVKKNGLDILCETTDLAHITKSMGTLKGKSP---IIFYLKLRHNNLPKL--QGFV-FLALDI 106
            |.|..|...|.:.||...:..:::.       ||   .|::|.|..|.|.:|  ..|| :....|
Human    52 CPCEEKDGILTVSCENRGIISLSEI-------SPPRFPIYHLLLSGNLLNRLYPNEFVNYTGASI 109

  Fly   107 RHLTIHNSSLAAIEENALSSLGAGLTQLDVSLNQMKTVPSQALQHLFHLLILNLNHNKITVIHNN 171
            .||  .::.:..||..|...| .||.:|.::.|:::.:.......|.:|..|.:::|.|:||..|
Human   110 LHL--GSNVIQDIETGAFHGL-RGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNYISVIEPN 171

  Fly   172 AFEGLETLEILTLYENKITQIDPEAFR--------------------GLEDHIKRL--------- 207
            ||..|..|::|.|.:|.::.:....||                    ||..|:.::         
Human   172 AFGKLHLLQVLILNDNLLSSLPNNLFRFVPLTHLDLRGNRLKLLPYVGLLQHMDKVVELQLEENP 236

  Fly   208 --------------------------------NLGGNDLTNI-----------------PQKALS 223
                                            .|.|.||..:                 ||..||
Human   237 WNCSCELISLKDWLDSISYSALVGDVVCETPFRLHGRDLDEVSKQELCPRRLISDYEMRPQTPLS 301

  Fly   224 ILSTL------------------------------------------------------------ 228
            ....|                                                            
Human   302 TTGYLHTTPASVNSVATSSSAVYKPPLKPPKGTRQPNKPRVRPTSRQPSKDLGYSNYGPSIAYQT 366

  Fly   229 ---------------------------------------------KKLEIQENKIRTISEGDFEG 248
                                                         ||:.:.||.|..:...||..
Human   367 KSPVPLECPTACSCNLQISDLGLNVNCQERKIESIAELQPKPYNPKKMYLTENYIAVVRRTDFLE 431

  Fly   249 LQSLDSLILAHNMITTVPANVFSHLTLLNSLELEGNKISVIDKDAFKGLEENLQYLRLGDNQIHT 313
            ...||.|.|.:|.|:.:....|..||.|..|.|.||:|..:..:.|.|| ::||||.|..|.|..
Human   432 ATGLDLLHLGNNRISMIQDRAFGDLTNLRRLYLNGNRIERLSPELFYGL-QSLQYLFLQYNLIRE 495

  Fly   314 IPSEALRPLHRLRHLDLRNNNINVLAEDAFTGFGDSLTFLNLQKNDIKVLPSLLFENLNSLETLN 378
            |.|....|:..|:.|.|.||.:..:....|:|    ||.|.                      ||
Human   496 IQSGTFDPVPNLQLLFLNNNLLQAMPSGVFSG----LTLLR----------------------LN 534

  Fly   379 LQNNKLQRIPQDIMEPVIDTLRI---IDITDNPLNCSCELTWFPKLLEDLK-------------- 426
            |::|....:|   :..|:|.|:.   ||:.|||.:|:|::......:|.||              
Human   535 LRSNHFTSLP---VSGVLDQLKSLIQIDLHDNPWDCTCDIVGMKLWVEQLKVGVLVDEVICKAPK 596

  Fly   427 --NKDDEMSQKKKPLCHMSLDNREYFVQAMPTEK-----------MHCAGLNVSPSPTS----GG 474
              .:.|..|.|.:.||....|    .|.:.||..           .....||.:.:|.|    ||
Human   597 KFAETDMRSIKSELLCPDYSD----VVVSTPTPSSIQVPARTSAVTPAVRLNSTGAPASLGAGGG 657

  Fly   475 LMRI-LQVNILAQIAVCSVAFLTSV 498
            ...: |.|.||:.:.|    |:.||
Human   658 ASSVPLSVLILSLLLV----FIMSV 678

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG14762NP_001246198.1 leucine-rich repeat 85..105 CDD:275380 7/22 (32%)
LRR_RI 93..384 CDD:238064 93/476 (20%)
leucine-rich repeat 107..129 CDD:275380 6/21 (29%)
leucine-rich repeat 131..154 CDD:275380 4/22 (18%)
LRR_8 154..214 CDD:290566 21/120 (18%)
leucine-rich repeat 155..178 CDD:275380 10/22 (45%)
leucine-rich repeat 179..203 CDD:275380 8/43 (19%)
leucine-rich repeat 204..227 CDD:275380 8/80 (10%)
LRR_8 226..286 CDD:290566 22/164 (13%)
leucine-rich repeat 228..251 CDD:275380 8/127 (6%)
leucine-rich repeat 252..275 CDD:275380 8/22 (36%)
LRR_8 276..335 CDD:290566 24/58 (41%)
leucine-rich repeat 276..300 CDD:275380 9/23 (39%)
leucine-rich repeat 301..324 CDD:275380 10/22 (45%)
leucine-rich repeat 325..349 CDD:275380 7/23 (30%)
LRR_8 349..409 CDD:290566 15/62 (24%)
leucine-rich repeat 350..373 CDD:275380 3/22 (14%)
SLITRK5NP_001371538.1 leucine-rich repeat 62..79 CDD:275380 3/23 (13%)
LRR <72..319 CDD:227223 50/256 (20%)
LRR 1 82..103 7/20 (35%)
leucine-rich repeat 83..106 CDD:275380 8/22 (36%)
LRR 2 106..127 6/22 (27%)
leucine-rich repeat 107..130 CDD:275380 7/25 (28%)
LRR_8 129..189 CDD:404697 19/59 (32%)
LRR 3 130..151 4/20 (20%)
leucine-rich repeat 131..154 CDD:275380 4/22 (18%)
LRR 4 154..175 9/20 (45%)
leucine-rich repeat 155..178 CDD:275380 10/22 (45%)
LRR 5 178..199 5/20 (25%)
leucine-rich repeat 179..200 CDD:275380 6/20 (30%)
LRR 6 201..222 2/20 (10%)
leucine-rich repeat 202..226 CDD:275380 3/23 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 317..358 0/40 (0%)
PPP1R42 391..>563 CDD:411060 55/201 (27%)
LRR 7 410..431 7/20 (35%)
LRR_8 433..493 CDD:404697 24/60 (40%)
LRR 8 434..455 7/20 (35%)
leucine-rich repeat 435..458 CDD:275378 8/22 (36%)
LRR 9 458..479 7/20 (35%)
leucine-rich repeat 459..482 CDD:275378 9/23 (39%)
LRR 10 482..503 9/20 (45%)
leucine-rich repeat 483..530 CDD:275378 18/50 (36%)
LRR 11 506..527 6/20 (30%)
LRR 12 529..550 8/45 (18%)
leucine-rich repeat 531..554 CDD:275378 9/47 (19%)
leucine-rich repeat 555..567 CDD:275378 5/11 (45%)
TPKR_C2 563..>599 CDD:417692 7/35 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 789..844
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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