DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14762 and cyr1

DIOPT Version :9

Sequence 1:	NP_001246198.1	Gene:	CG14762 / 35768	FlyBaseID:	FBgn0033250	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	NP_596159.1	Gene:	cyr1 / 2540810	PomBaseID:	SPBC19C7.03	Length:	1692	Species:	Schizosaccharomyces pombe

Alignment Length:	555	Identity:	113/555 - (20%)
Similarity:	203/555 - (36%)	Gaps:	189/555 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 VFLALDIRHLTIHNSSLAAIEENALSSLGAGLTQLDVSLNQMKTVPSQALQHLFHLLILNLNHN- 163
            ||..:||....:...|...|..|           ||:|.:.::.:|.:...:...|:.||::||
pombe   387 VFTTMDIGADVLRKFSEKKITAN-----------LDISRSNLEVIPVKIYPYAHELISLNVSHNL 440

  Fly   164 ---------------KITVIHNN-------AFEGLETLEILTLYENKITQIDPEAFRGL-EDHIK 205
                           |...|.||       ....|..||:|.:..|.|.::||..|.|| .:.:|
pombe   441 SLDLPLDFMERCVKLKRLDISNNLRSPRGKPITALRQLEVLNMSRNDIYELDPLIFSGLSRNSLK 505

  Fly   206 RLNLGGNDLTNIPQKA----------------------LSILSTLKKLEIQENKIRTISE----- 243
            .||:..|.|..:|...                      ::.||.|:.|....|.:..||.
pombe   506 ELNIANNKLFFLPHSTRYLVNLTYLDLSYNNFVTFPLIITELSQLETLNFSHNLLSQISSKIGSL 570

  Fly   244 ----------GDFEG--------LQSLDSLILAHNMITTVPANVFSHLTLLNSLELEGNKIS--- 287
                      .|...        |::|:::.|::|.||.:.:  .|....|||:.:..|.:|
pombe   571 VKLKHLYLQFNDLSNRLPQEIGLLKNLETIDLSYNAITNIAS--LSECPKLNSINVACNLLSFYE 633

  Fly   288 -----------------VIDKDAFK---------------GLEE-------NLQYLRLGDNQIHT 313
                             .|| .||.               ||::       |::.:::..|...:
pombe   634 YSNPSATFIDFSFCPLTTID-PAFSYSNLVYFDISHAKLIGLKDSVIETLVNVETVKVNYNHFTS 697

  Fly   314 IPSEALRPLHRLRHLDLRNNNINVLAEDAFTGFGDSLTFLNLQKNDIKVLPSLLFENLNSLETLN 378
            | |:|:..:..|::|...|..::.::.:  .|....|..|:|..|:||:.|..::: ::||:.:|
pombe   698 I-SDAISAMQNLKYLSCTNCEMSYVSPN--LGKLKHLVHLDLHANNIKIFPEEVWQ-VSSLKVVN 758

  Fly   379 LQNNKLQRI--------------------------------PQDIMEPVIDTLRIIDITDNPL-- 409
            |.:|.|::|                                .|:.:.|.::.|.::   ||.|
pombe   759 LSSNILEKIKLPVATSKKLTRTISQLKIMRTLSGNPVSSLSSQEFVMPTVEELYLV---DNRLGN 820

  Fly   410 NCSCELTWFPKL---------LEDLKNKDDEMSQKKKPLCHMSLDNREYFVQAMPT------EKM 459
            :|...|.:|..|         |.::.:|   ..|....|.|:.:...|....::.:      |.:
pombe   821 DCFTALEYFKCLKVLNLSYNYLTEIPSK---FFQNFSDLKHLFVSGNELANLSISSTAQVLLETL 882

  Fly   460 HCAGLNVSPSPTSGGL---MRILQV--NILAQIAV 489
            :..|..:|..|.:..|   :|.|.:  |.|..:||
pombe   883 YANGNRLSSFPKNEALSKSLRFLDISTNNLQNLAV 917

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14762	NP_001246198.1	leucine-rich repeat	85..105	CDD:275380	2/4 (50%)
		LRR_RI	93..384	CDD:238064	84/394 (21%)
		leucine-rich repeat	107..129	CDD:275380	3/21 (14%)
		leucine-rich repeat	131..154	CDD:275380	4/22 (18%)
		LRR_8	154..214	CDD:290566	24/83 (29%)
		leucine-rich repeat	155..178	CDD:275380	10/45 (22%)
		leucine-rich repeat	179..203	CDD:275380	10/24 (42%)
		leucine-rich repeat	204..227	CDD:275380	7/44 (16%)
		LRR_8	226..286	CDD:290566	18/82 (22%)
		leucine-rich repeat	228..251	CDD:275380	7/45 (16%)
		leucine-rich repeat	252..275	CDD:275380	6/22 (27%)
		LRR_8	276..335	CDD:290566	19/100 (19%)
		leucine-rich repeat	276..300	CDD:275380	11/65 (17%)
		leucine-rich repeat	301..324	CDD:275380	4/22 (18%)
		leucine-rich repeat	325..349	CDD:275380	4/23 (17%)
		LRR_8	349..409	CDD:290566	19/91 (21%)
		leucine-rich repeat	350..373	CDD:275380	7/22 (32%)
cyr1	NP_596159.1	Ad_cyc_g-alpha	155..200	CDD:129025
		UBQ	292..387	CDD:294102	113/555 (20%)
		leucine-rich repeat	409..430	CDD:275380	5/31 (16%)
		leucine-rich repeat	431..454	CDD:275380	5/22 (23%)
		LRR_RI	<441..616	CDD:238064	36/176 (20%)
		leucine-rich repeat	455..477	CDD:275380	5/21 (24%)
		LRR_8	476..537	CDD:290566	16/60 (27%)
		leucine-rich repeat	478..503	CDD:275380	10/24 (42%)
		leucine-rich repeat	504..526	CDD:275380	6/21 (29%)
		leucine-rich repeat	527..549	CDD:275380	1/21 (5%)
		LRR_8	548..607	CDD:290566	11/58 (19%)
		leucine-rich repeat	550..572	CDD:275380	5/21 (24%)
		leucine-rich repeat	573..596	CDD:275380	2/22 (9%)
		leucine-rich repeat	597..618	CDD:275380	6/22 (27%)
		leucine-rich repeat	661..684	CDD:275380	2/22 (9%)
		leucine-rich repeat	685..707	CDD:275380	4/22 (18%)
		leucine-rich repeat	708..730	CDD:275380	4/23 (17%)
		LRR_RI	<724..941	CDD:238064	42/203 (21%)
		leucine-rich repeat	754..783	CDD:275380	6/28 (21%)
		leucine-rich repeat	784..807	CDD:275380	1/22 (5%)
		leucine-rich repeat	808..831	CDD:275380	7/25 (28%)
		LRR_8	832..889	CDD:290566	9/59 (15%)
		leucine-rich repeat	832..855	CDD:275380	4/25 (16%)
		leucine-rich repeat	856..877	CDD:275380	3/20 (15%)
		leucine-rich repeat	879..901	CDD:275380	5/21 (24%)
		leucine-rich repeat	902..930	CDD:275380	6/16 (38%)
		PP2C	1032..1268	CDD:278884
		CYCc	1300..1488	CDD:214485
		Nucleotidyl_cyc_III	1323..1519	CDD:299850
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	1	0.960