DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14762 and Lingo2

DIOPT Version :9

Sequence 1:	NP_001246198.1	Gene:	CG14762 / 35768	FlyBaseID:	FBgn0033250	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	NP_001159471.1	Gene:	Lingo2 / 242384	MGIID:	2442298	Length:	606	Species:	Mus musculus

Alignment Length:	429	Identity:	107/429 - (24%)
Similarity:	184/429 - (42%)	Gaps:	63/429 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 VTVVLLLQVLVMDQVLGQGPPQTQVCPEQSEIAPCICTVKKNGLDILCETTDLAHITKSMGTLKG 78
            :.|||||    |...:|        ||     |.|.|:.:..  .:.|....|..|.:.:
Mouse    15 LAVVLLL----MGSTIG--------CP-----ARCECSAQNK--SVSCHRRRLLAIPEGI----- 55

  Fly    79 KSPI-IFYLKLRHNNLPKLQGFVFLALDIRHLTIHNSSLAAIEENALSSLGAGLTQLDVSLNQMK 142
              || ...|.|..|.|..:....|::..:                        |.::|:|.|.:.
Mouse    56 --PIETKILDLSKNRLKSINPEEFISYPL------------------------LEEIDLSDNIIA 94

  Fly   143 TVPSQALQHLFHLLILNLNHNKITVIHNNAFEGLETLEILTLYENKITQIDPEAFRGLEDHIKRL 207
            .|...|..:||:|..|.|..|::.::....|.||..|..|.:.||||..:....|:.|. ::|.|
Mouse    95 NVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLH-NLKSL 158

  Fly   208 NLGGNDLTNIPQKALSILSTLKKLEIQENKIRTISEGDFEGLQSLDSLILAHNMITTVPANVFSH 272
            .:|.|||..|..:|.|.|.:|::|.:::..:..:.......|:||.:|.|.|..|..:|...|..
Mouse   159 EVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLIALHLKHLNINNMPVYAFKR 223

  Fly   273 LTLLNSLELE-GNKISVIDKDAFKGLEENLQYLRLGDNQIHTIPSEALRPLHRLRHLDLRNNNIN 336
            |..|.:||:: ...:.::..::..||  ||..|.:.:..:.|:|..|.:.|..|.||:|..|.|:
Mouse   224 LFHLKNLEIDYWPLLDLMPANSLYGL--NLTSLSITNTNLSTVPFLAFKHLVYLTHLNLSYNPIS 286

  Fly   337 VLAEDAFTGFGDSLTFLNLQKNDIKVLPSLLFENLNSLETLNLQNNKLQRIPQDIMEPVIDTLRI 401
            .:....|:.. ..|..|::....::.:....|:.|..|..||:..|.|:.:.:::.... ..|.:
Mouse   287 TIEAGMFSDL-IRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSP-RALEV 349

  Fly   402 IDITDNPLNCSCELTWFPKLLEDLKNKDDEMSQKKKPLC 440
            :.|.:|||.|.|.|.|.      |:.:.:.....::|:|
Mouse   350 LSINNNPLACDCRLLWL------LQRQPNLQFGGQQPMC 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14762	NP_001246198.1	leucine-rich repeat	85..105	CDD:275380	5/19 (26%)
		LRR_RI	93..384	CDD:238064	74/291 (25%)
		leucine-rich repeat	107..129	CDD:275380	0/21 (0%)
		leucine-rich repeat	131..154	CDD:275380	7/22 (32%)
		LRR_8	154..214	CDD:290566	19/59 (32%)
		leucine-rich repeat	155..178	CDD:275380	7/22 (32%)
		leucine-rich repeat	179..203	CDD:275380	8/23 (35%)
		leucine-rich repeat	204..227	CDD:275380	10/22 (45%)
		LRR_8	226..286	CDD:290566	15/60 (25%)
		leucine-rich repeat	228..251	CDD:275380	3/22 (14%)
		leucine-rich repeat	252..275	CDD:275380	8/22 (36%)
		LRR_8	276..335	CDD:290566	17/59 (29%)
		leucine-rich repeat	276..300	CDD:275380	5/24 (21%)
		leucine-rich repeat	301..324	CDD:275380	6/22 (27%)
		leucine-rich repeat	325..349	CDD:275380	7/23 (30%)
		LRR_8	349..409	CDD:290566	12/59 (20%)
		leucine-rich repeat	350..373	CDD:275380	4/22 (18%)
Lingo2	NP_001159471.1	LRRNT	27..60	CDD:214470	11/54 (20%)
		leucine-rich repeat	39..57	CDD:275380	3/26 (12%)
		LRR 1	58..79		5/20 (25%)
		leucine-rich repeat	59..82	CDD:275380	5/22 (23%)
		LRR_8	60..117	CDD:404697	17/80 (21%)
		LRR 2	82..103		6/44 (14%)
		leucine-rich repeat	83..106	CDD:275380	7/22 (32%)
		LRR_8	106..165	CDD:404697	19/59 (32%)
		LRR 3	106..127		5/20 (25%)
		leucine-rich repeat	107..130	CDD:275380	7/22 (32%)
		LRR 4	130..151		7/20 (35%)
		leucine-rich repeat	131..154	CDD:275380	8/23 (35%)
		LRR 5	154..175		8/20 (40%)
		leucine-rich repeat	155..178	CDD:275380	10/22 (45%)
		PPP1R42	176..>373	CDD:411060	51/206 (25%)
		LRR 6	178..199		2/20 (10%)
		leucine-rich repeat	179..202	CDD:275380	3/22 (14%)
		LRR 7	202..223		8/20 (40%)
		leucine-rich repeat	203..250	CDD:275380	13/48 (27%)
		LRR 8	226..247		3/20 (15%)
		LRR 9	250..271		6/20 (30%)
		leucine-rich repeat	251..274	CDD:275380	6/22 (27%)
		LRR 10	274..295		7/20 (35%)
		leucine-rich repeat	275..298	CDD:275380	7/23 (30%)
		LRR 11	298..319		3/20 (15%)
		leucine-rich repeat	299..322	CDD:275380	4/22 (18%)
		LRR 12	322..343		5/20 (25%)
		leucine-rich repeat	323..343	CDD:275380	5/19 (26%)
		LRRCT	355..408	CDD:214507	10/34 (29%)
		Ig	411..500	CDD:416386
		Ig strand A'	417..421	CDD:409353
		Ig strand B	427..436	CDD:409353
		Ig strand C	441..446	CDD:409353
		Ig strand C'	449..451	CDD:409353
		Ig strand D	460..463	CDD:409353
		Ig strand E	466..473	CDD:409353
		Ig strand F	479..487	CDD:409353
		Ig strand G	490..500	CDD:409353
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910