DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14762 and Lingo1

DIOPT Version :9

Sequence 1:	NP_001246198.1	Gene:	CG14762 / 35768	FlyBaseID:	FBgn0033250	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	XP_006511149.1	Gene:	Lingo1 / 235402	MGIID:	1915522	Length:	647	Species:	Mus musculus

Alignment Length:	398	Identity:	105/398 - (26%)
Similarity:	174/398 - (43%)	Gaps:	48/398 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 VLVMDQVLGQGPPQTQVCPEQSEIAPCICTVKKNGLDILCETTDLAHITKSMGTLKGKSPIIFYL 86
            :||:..||.   .....||.:     |.|:.:...  :||      |..:.:...:|.......|
Mouse    55 LLVLGSVLS---GSATGCPPR-----CECSAQDRA--VLC------HRKRFVAVPEGIPTETRLL 103

  Fly    87 KLRHNNLPKLQGFVFLAL-DIRHLTIHNSSLAAIEENALSSLGAGLTQLDVSLNQMKTVPSQALQ 150
            .|..|.:..|....|.:. .:..|.::.:.::|:|..|.::| ..|..|.:..|::|.:|.....
Mouse   104 DLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNL-FNLRTLGLRSNRLKLIPLGVFT 167

  Fly   151 HLFHLLILNLNHNKITVIHNNAFEGLETLEILTLYENKITQIDPEAFRGLEDHIKRLNLGGNDLT 215
            .|.:|..|:::.|||.::.:..|:.|..|:.|.:.:|.:..|...||.|| :.:::|.|...:||
Mouse   168 GLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGL-NSLEQLTLEKCNLT 231

  Fly   216 NIPQKALSILSTLKKLEIQENKIRTISEGDFEGLQSLDSLILAH-NMITTVPANVFSHLTLLNSL 279
            :||.:|||.|..|..|.::...|..|.:..|:.|..|..|.::| ..:.|:..|....|. |.||
Mouse   232 SIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGLN-LTSL 295

  Fly   280 ELEGNKISVIDKDAFKGLEENLQYLRLGDNQIHTIPSEALRPLHRLRHLDLRNNNINVLAEDAFT 344
            .:....::.:...|.:.| ..|::|.|..|.|.||....|..|.||:.:.|....:.|:...||.
Mouse   296 SITHCNLTAVPYLAVRHL-VYLRFLNLSYNPIGTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFR 359

  Fly   345 GFGDSLTFLNLQKNDIKVLPSLLFENLNSLETLNLQNNKLQRIPQDIMEPVIDTLRIIDITDNPL 409
            |. :.|..||:..|.:..|....|.::.:||||                       |:|  .|||
Mouse   360 GL-NYLRVLNVSGNQLTTLEESAFHSVGNLETL-----------------------ILD--SNPL 398

  Fly   410 NCSCELTW 417
            .|.|.|.|
Mouse   399 ACDCRLLW 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14762	NP_001246198.1	leucine-rich repeat	85..105	CDD:275380	5/20 (25%)
		LRR_RI	93..384	CDD:238064	81/292 (28%)
		leucine-rich repeat	107..129	CDD:275380	5/21 (24%)
		leucine-rich repeat	131..154	CDD:275380	6/22 (27%)
		LRR_8	154..214	CDD:290566	17/59 (29%)
		leucine-rich repeat	155..178	CDD:275380	7/22 (32%)
		leucine-rich repeat	179..203	CDD:275380	8/23 (35%)
		leucine-rich repeat	204..227	CDD:275380	10/22 (45%)
		LRR_8	226..286	CDD:290566	15/60 (25%)
		leucine-rich repeat	228..251	CDD:275380	6/22 (27%)
		leucine-rich repeat	252..275	CDD:275380	6/23 (26%)
		LRR_8	276..335	CDD:290566	17/58 (29%)
		leucine-rich repeat	276..300	CDD:275380	5/23 (22%)
		leucine-rich repeat	301..324	CDD:275380	9/22 (41%)
		leucine-rich repeat	325..349	CDD:275380	6/23 (26%)
		LRR_8	349..409	CDD:290566	13/59 (22%)
		leucine-rich repeat	350..373	CDD:275380	6/22 (27%)
Lingo1	XP_006511149.1	LRRNT	68..102	CDD:214470	8/46 (17%)
		LRR	<93..398	CDD:227223	88/334 (26%)
		leucine-rich repeat	100..123	CDD:275380	5/22 (23%)
		leucine-rich repeat	124..147	CDD:275380	5/23 (22%)
		LRR_8	147..206	CDD:338972	16/58 (28%)
		leucine-rich repeat	148..171	CDD:275380	6/22 (27%)
		leucine-rich repeat	172..219	CDD:275380	15/47 (32%)
		leucine-rich repeat	220..243	CDD:275380	10/22 (45%)
		leucine-rich repeat	244..291	CDD:275380	11/46 (24%)
		leucine-rich repeat	292..315	CDD:275380	5/23 (22%)
		leucine-rich repeat	316..339	CDD:275380	9/22 (41%)
		leucine-rich repeat	340..363	CDD:275380	6/23 (26%)
		leucine-rich repeat	364..384	CDD:275380	6/19 (32%)
		PCC	368..>448	CDD:188093	17/64 (27%)
		Ig	466..541	CDD:386229
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910