DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG14762 and Slit3

DIOPT Version :9

Sequence 1:NP_001246198.1 Gene:CG14762 / 35768 FlyBaseID:FBgn0033250 Length:498 Species:Drosophila melanogaster
Sequence 2:NP_035542.2 Gene:Slit3 / 20564 MGIID:1315202 Length:1523 Species:Mus musculus


Alignment Length:479 Identity:122/479 - (25%)
Similarity:187/479 - (39%) Gaps:128/479 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   112 HNSSLAAIEENALSSLGAGLTQLDVSLNQMKTVPSQALQHLFHLLILNLNHNKITVIHNNAFEGL 176
            |...|.|:..    .:.....:||:..|.:..:.......|.:|.:|:|..|::::|...||:.|
Mouse    48 HGLGLRAVPR----GIPRNAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSIIERGAFQDL 108

  Fly   177 ETLEILTLYENKITQIDPEAFRGLEDHIKRLNLGGNDLTNIPQKALSILSTLKKLEIQENKIRTI 241
            :.||.|.|.:||: |:.||........:.||:|..|.:..||:||...::.:|.|::..|.|..|
Mouse   109 KQLERLRLNKNKL-QVLPELLFQSTPKLTRLDLSENQIQGIPRKAFRGVTGVKNLQLDNNHISCI 172

  Fly   242 SEGDFEGLQSLDSLILAHNMITTVPANVFSHLTLLNSLELEGNKI-------------------- 286
            .:|.|..|:.|:.|.|.:|.|:.:....|:|:..:.:|.|..|.:                    
Mouse   173 EDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQRRTIG 237

  Fly   287 --------------SVID--KDAF----------------------------------KG----- 296
                          ||.|  |..:                                  ||     
Mouse   238 QFTLCMAPVHLRGFSVADVQKKEYVCPGPHSEAPACNANSLSCPSACSCSNNIVDCRGKGLTEIP 302

  Fly   297 --LEENLQYLRLGDNQIHTIPSEALRPLHRLRHLDLRNNNINVLAEDAFTGFGDSLTFLNLQKND 359
              |.|.:..:||..|.|.:||:.|.....:|:.:|:..|.|:.:|.|||.|. .|||.|.|..|.
Mouse   303 ANLPEGIVEIRLEQNSIKSIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGL-KSLTSLVLYGNK 366

  Fly   360 IKVLPSLLFENLNSLETL----------------NLQN--------NKLQRIPQDIMEPVIDTLR 400
            |..:|..||:.|.||:.|                :|||        ||||.|.:.:..| :.:::
Mouse   367 ITEIPKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFVP-LQSIQ 430

  Fly   401 IIDITDNPLNCSCELTWFPKLLED---------------LKNKDDEMSQKKKPLCHMSLDNR--- 447
            .:.:..||..|.|.|.|....|:|               |.||.....:.||..|..|.|.|   
Mouse   431 TLHLAQNPFVCDCHLKWLADYLQDNPIETSGARCSSPRRLANKRISQIKSKKFRCSGSEDYRNRF 495

  Fly   448 --EYFVQAMPTEKMHCAGLNVSPS 469
              |.|:..:..||..|.|..|..|
Mouse   496 SSECFMDLVCPEKCRCEGTIVDCS 519

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG14762NP_001246198.1 leucine-rich repeat 85..105 CDD:275380
LRR_RI 93..384 CDD:238064 92/372 (25%)
leucine-rich repeat 107..129 CDD:275380 3/16 (19%)
leucine-rich repeat 131..154 CDD:275380 4/22 (18%)
LRR_8 154..214 CDD:290566 21/59 (36%)
leucine-rich repeat 155..178 CDD:275380 8/22 (36%)
leucine-rich repeat 179..203 CDD:275380 9/23 (39%)
leucine-rich repeat 204..227 CDD:275380 8/22 (36%)
LRR_8 226..286 CDD:290566 18/59 (31%)
leucine-rich repeat 228..251 CDD:275380 8/22 (36%)
leucine-rich repeat 252..275 CDD:275380 7/22 (32%)
LRR_8 276..335 CDD:290566 21/135 (16%)
leucine-rich repeat 276..300 CDD:275380 10/100 (10%)
leucine-rich repeat 301..324 CDD:275380 7/22 (32%)
leucine-rich repeat 325..349 CDD:275380 9/23 (39%)
LRR_8 349..409 CDD:290566 24/83 (29%)
leucine-rich repeat 350..373 CDD:275380 10/22 (45%)
Slit3NP_035542.2 LRRNT 33..60 CDD:279764 3/15 (20%)
LRR_RI <49..220 CDD:238064 49/175 (28%)
LRR_8 61..121 CDD:290566 17/59 (29%)
LRR 1 62..83 3/20 (15%)
leucine-rich repeat 64..86 CDD:275380 4/21 (19%)
LRR 2 86..107 7/20 (35%)
leucine-rich repeat 87..110 CDD:275380 8/22 (36%)
LRR_8 109..169 CDD:290566 20/60 (33%)
LRR 3 110..131 9/21 (43%)
leucine-rich repeat 111..134 CDD:275380 9/23 (39%)
LRR 4 134..155 8/20 (40%)
leucine-rich repeat 135..158 CDD:275380 8/22 (36%)
LRR_8 157..217 CDD:290566 18/59 (31%)
LRR 5 158..179 7/20 (35%)
leucine-rich repeat 159..182 CDD:275380 8/22 (36%)
LRR 6 182..203 6/20 (30%)
leucine-rich repeat 183..206 CDD:275380 7/22 (32%)
leucine-rich repeat 207..309 CDD:275380 11/101 (11%)
LRRNT 280..311 CDD:214470 4/30 (13%)
LRR 7 308..329 7/20 (35%)
LRR_8 311..367 CDD:290566 22/56 (39%)
leucine-rich repeat 311..332 CDD:275380 7/20 (35%)
LRR_4 331..371 CDD:289563 16/40 (40%)
LRR 8 332..353 8/20 (40%)
leucine-rich repeat 333..356 CDD:275380 9/23 (39%)
LRR_8 355..439 CDD:290566 24/84 (29%)
LRR 9 356..377 10/20 (50%)
leucine-rich repeat 357..377 CDD:275380 9/19 (47%)
LRR 10 380..401 3/20 (15%)
leucine-rich repeat 381..404 CDD:275380 3/22 (14%)
LRR 11 404..425 6/20 (30%)
leucine-rich repeat 405..426 CDD:275380 6/21 (29%)
leucine-rich repeat 429..522 CDD:275380 25/91 (27%)
TPKR_C2 437..>467 CDD:301599 8/29 (28%)
LRRNT 505..535 CDD:214470 6/15 (40%)
LRR 12 533..554
leucine-rich repeat 534..558 CDD:275380
LRR_4 535..574 CDD:289563
LRR_8 557..617 CDD:290566
LRR 13 558..579
leucine-rich repeat 559..582 CDD:275380
LRR 14 582..603
leucine-rich repeat 583..606 CDD:275380
LRR_8 605..665 CDD:290566
LRR 15 606..627
leucine-rich repeat 607..630 CDD:275380
LRR 16 630..651
leucine-rich repeat 631..654 CDD:275380
leucine-rich repeat 655..745 CDD:275380
LRRCT 663..712 CDD:214507
LRRNT 725..756 CDD:214470
leucine-rich repeat 746..776 CDD:275380
LRR_RI <751..869 CDD:238064
LRR 17 753..774
LRR_8 775..835 CDD:290566
LRR 18 776..797
leucine-rich repeat 777..800 CDD:275380
LRR 19 800..821
leucine-rich repeat 801..824 CDD:275380
LRR 20 824..845
leucine-rich repeat 825..846 CDD:275380
LRRCT 857..906 CDD:214507
EGF_CA 956..994 CDD:238011
EGF_CA 998..1031 CDD:238011
EGF_CA 1035..1072 CDD:238011
EGF_CA 1076..1110 CDD:238011
EGF 1123..1153 CDD:278437
Laminin_G_2 1188..1314 CDD:280389
GHB_like 1463..1519 CDD:304424
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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