Protein Alignment CG14762 and let-4

DIOPT Version :10

• Sequence 1: NP_001246198.1
• Gene: CG14762 / 35768
• FlyBaseID: FBgn0033250
• Length: 498
• Species: Drosophila melanogaster
• Sequence 2: NP_510425.2
• Gene: let-4 / 181554
• WormBaseID: WBGene00002282
• Length: 773
• Species: Caenorhabditis elegans
• Alignment Length: 467
• Identity: 130/467 - (27%)
• Similarity: 227/467 - (48%)
• Gaps: 29/467 - (6%)

  Fly    18 LLLQVLVMDQVLGQGPPQTQVCPEQSEIAPCICTVKKNGLDILCETTDLAHITKSMGTLKGKSPI 82
            |||.:|:...:|..   .|..||.....| |.|:...:|:.:.|..:..:.|.:.:.|.:.:..:
 Worm     3 LLLCLLLFSTLLIN---STNACPGVITQA-CFCSEVHSGIVLDCSNSSASGILQIIRTNQAQVGL 63

  Fly    83 IFYLKLRHNNLPKLQGFVFLALDIRHLTIHNSSLAAIEENALSSLGAGLTQLDVSLNQMKTVPSQ 147
            |..|.:....|.:|....|..|.||.|.:..:.:..|::.|.:.:...|.::.::.|.::.||:.
 Worm    64 IQSLTMNQAELVELPPNFFSGLFIRRLDLSQNKIKKIDDAAFAGINPVLEEVVLNHNLIEKVPAA 128

  Fly   148 ALQHLFHLLILNLNHNKITVI-HNNAFEGLETLEILTLYENKITQIDPEAFRGLEDHIKRLNLGG 211
            ||..|.:||.|:|::|.|..| ....|..|..|..:.|..|||..|....|:.:::.|:.:|||.
 Worm   129 ALAGLPNLLRLDLSNNSIVEIQEQEIFPNLNKLYDINLGSNKIFSIHTSTFQNVKNSIQTINLGH 193

  Fly   212 NDLTNIPQKALSILSTLKKLEIQENKIRTISEGDFEGLQSLDSLILAHNMITTVPANVFSHLTLL 276
            |::|.:|..|:..|..|:.|.:.:|:|..:...:|..|..|:.|.||.|.|..:....|.::..|
 Worm   194 NNMTAVPSSAIRGLKQLQSLHLHKNRIEQLDALNFLNLPVLNLLNLAGNQIHELNRQAFLNVPSL 258

  Fly   277 NSLELEGNKISVIDKDAFKGLEENLQYLRLGDNQIHTIPSEALRPLHRLRHLDLRNNNINVLAED 341
            ..|.|.||||:.:....|:..|: |:.|.|.:|:|..||:.:|..|.:||.|.|.:|.|:.::.:
 Worm   259 RYLYLSGNKITKLTAYQFQTFEQ-LEMLDLTNNEIGAIPANSLSGLKQLRQLYLAHNKISNISSN 322

  Fly   342 AFTGFGDSLTFLNLQKNDIKVLPSLLFENLNSLETLNLQNNKLQRIPQDIMEPVIDTLRIIDITD 406
            |||  ..|:..|.|..|::|.|.:.:...|.:|:.::.::|:::.|.::...... :|.::|:..
 Worm   323 AFT--NSSIVVLVLSSNELKTLTAGIISGLPNLQQVSFRDNQIKTINRNAFYDAA-SLVMLDLAK 384

  Fly   407 NPLNCSCELTWFPK---LLEDLKNKDDEMSQKKKPLCHMSLDNRE---YFVQAMP---TEKMHC- 461
            |.|......|:..:   ||.||       |:.|.|....|..|..   ..::..|   ||.:|.
 Worm   385 NQLTEIAPTTFLAQLNLLLVDL-------SENKLPKTPYSAFNSRVGTVLLKENPLVCTENLHML 442

  Fly   462 ---AGLNVSPSP 470
               .|:.|..||
 Worm   443 QQGTGVYVRDSP 454

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14762	NP_001246198.1	leucine-rich repeat	85..105	CDD:275380	4/19 (21%)
		leucine-rich repeat	107..129	CDD:275380	4/21 (19%)
		LRR	<131..410	CDD:443914	85/279 (30%)
		leucine-rich repeat	131..154	CDD:275380	7/22 (32%)
		leucine-rich repeat	155..178	CDD:275380	9/23 (39%)
		leucine-rich repeat	179..203	CDD:275380	7/23 (30%)
		leucine-rich repeat	204..227	CDD:275380	9/22 (41%)
		leucine-rich repeat	228..251	CDD:275380	6/22 (27%)
		leucine-rich repeat	252..275	CDD:275380	7/22 (32%)
		leucine-rich repeat	276..300	CDD:275380	9/23 (39%)
		leucine-rich repeat	301..324	CDD:275380	9/22 (41%)
		leucine-rich repeat	325..349	CDD:275380	9/23 (39%)
		leucine-rich repeat	350..373	CDD:275380	6/22 (27%)
let-4	NP_510425.2	leucine-rich repeat	66..86	CDD:275380	4/19 (21%)
		LRR	85..414	CDD:443914	100/339 (29%)
		leucine-rich repeat	88..111	CDD:275380	4/22 (18%)
		leucine-rich repeat	112..135	CDD:275380	7/22 (32%)
		leucine-rich repeat	136..160	CDD:275380	9/23 (39%)
		leucine-rich repeat	161..184	CDD:275380	7/22 (32%)
		leucine-rich repeat	186..209	CDD:275380	9/22 (41%)
		leucine-rich repeat	210..257	CDD:275380	13/46 (28%)
		leucine-rich repeat	258..281	CDD:275380	8/22 (36%)
		leucine-rich repeat	282..305	CDD:275380	9/22 (41%)
		leucine-rich repeat	306..328	CDD:275380	9/23 (39%)
		leucine-rich repeat	329..350	CDD:275380	5/20 (25%)
		leucine-rich repeat	353..400	CDD:275380	8/47 (17%)
		leucine-rich repeat	356..376	CDD:275380	2/20 (10%)
		leucine-rich repeat	401..419	CDD:275380	8/24 (33%)