DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14762 and lron-1

DIOPT Version :9

Sequence 1:	NP_001246198.1	Gene:	CG14762 / 35768	FlyBaseID:	FBgn0033250	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	NP_510424.4	Gene:	lron-1 / 181553	WormBaseID:	WBGene00008093	Length:	607	Species:	Caenorhabditis elegans

Alignment Length:	477	Identity:	127/477 - (26%)
Similarity:	208/477 - (43%)	Gaps:	74/477 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 VLLLQVLVMDQVLGQGPPQTQVCPEQSEIAPCICT-VKKNGLDILCE-TTDLAHITKSMGTLKGK 79
            :||..:|:...|..|       ||......||.|| .:...:.|.|: .:.|..:.:|:    ..
Worm     3 LLLFNLLIAGWVYSQ-------CPTLQLQEPCTCTSTRYEAVSINCDGGSSLDAVLESL----SN 56

  Fly    80 SP-IIFYLKLRHNNLPKLQGFVFLALDIRHLTIHNSSLAAIEENALS-SLGAGLTQLDVSLNQMK 142
            || .|..|.:.:..:.|:.|:.|....|:.|.:.|:.|.:...|..: :|...|.:|::..|.:.
Worm    57 SPQAIDSLTISNTPIEKMPGYAFQGFQIKKLFLRNNGLRSFHPNTFTGNLENSLEELEIRGNYID 121

  Fly   143 TVPSQALQHLFHLLILNLNHNKITVIHNNAF---EGLETLEILTLYENKITQIDPEAFRGLEDHI 204
            .:|...:..|..|.||:|..|.|..:.:|||   ...::|..|.|..|.:|.|.|....||| ::
Worm   122 GIPQSGVSILKQLKILSLPDNLIEYVQDNAFLSYHSRDSLLKLDLSANNLTAIHPTGLLGLE-NL 185

  Fly   205 KRLNLGGNDLTNIPQKALSILSTLKKLEIQENKIRTISEGDFEGLQSLDSLILAHNMITTVPANV 269
            .:|:|..|.|:.||.:||..:.:|:.|.:..|:|.|||..... |.:|.||.|..|.|..:|::.
Worm   186 SQLSLDKNLLSEIPSQALENIPSLEDLSLGVNRIHTISRNSLP-LPNLKSLSLEVNQIRLIPSDS 249

  Fly   270 FSHLTLLNSLELEGNKISVIDKDAF---KGLE--------------------------------- 298
            ||...||:.|.|..|.::.||...|   .||:
Worm   250 FSETPLLSYLYLGNNLLTSIDASMFLHIGGLKVLSMSNNKDITSIQANGKLSVQQFKLCICILAF 314

  Fly   299 ---ENLQYLRLGDNQIHTIPSEALRPLHRLRHLDLRNNNINVLAEDAFTGFGDSLTFLNLQKNDI 360
               .:|..|.|.|..|..|..::|:.:..::.:.|..|.|..::.|.|:...: |:.|:|..|.|
Worm   315 QHAPSLIRLELFDCSISRIEPKSLQKVQHIQVILLSRNQITRISHDTFSNLPE-LSELDLSGNSI 378

  Fly   361 KVLPSLLFENLNSLETLNLQNNKLQRIPQDIMEPVIDTL---------RIIDITDNPLNCSCELT 416
            ..:....|..|..|.:|:|.:|:|:.:|.::   :.|:|         |.:.|.:||..|..:|.
Worm   379 NAVDDFAFSQLPMLTSLDLSSNRLESLPSNV---IYDSLMQKKTSPVQRKLSIQNNPWRCDKDLM 440

  Fly   417 WFPKLLEDLKNKDDEMSQKKKP 438
            |..|.|.|  |.|...:....|
Worm   441 WLRKWLRD--NGDVTTAASNSP 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14762	NP_001246198.1	leucine-rich repeat	85..105	CDD:275380	4/19 (21%)
		LRR_RI	93..384	CDD:238064	91/333 (27%)
		leucine-rich repeat	107..129	CDD:275380	5/22 (23%)
		leucine-rich repeat	131..154	CDD:275380	5/22 (23%)
		LRR_8	154..214	CDD:290566	22/62 (35%)
		leucine-rich repeat	155..178	CDD:275380	9/25 (36%)
		leucine-rich repeat	179..203	CDD:275380	10/23 (43%)
		leucine-rich repeat	204..227	CDD:275380	8/22 (36%)
		LRR_8	226..286	CDD:290566	22/59 (37%)
		leucine-rich repeat	228..251	CDD:275380	8/22 (36%)
		leucine-rich repeat	252..275	CDD:275380	9/22 (41%)
		LRR_8	276..335	CDD:290566	18/97 (19%)
		leucine-rich repeat	276..300	CDD:275380	9/62 (15%)
		leucine-rich repeat	301..324	CDD:275380	7/22 (32%)
		leucine-rich repeat	325..349	CDD:275380	5/23 (22%)
		LRR_8	349..409	CDD:290566	18/68 (26%)
		leucine-rich repeat	350..373	CDD:275380	7/22 (32%)
lron-1	NP_510424.4	PRK15370	<58..>289	CDD:185268	71/232 (31%)
		leucine-rich repeat	85..109	CDD:275380	5/23 (22%)
		leucine-rich repeat	110..133	CDD:275380	5/22 (23%)
		leucine-rich repeat	134..157	CDD:275380	9/22 (41%)
		leucine-rich repeat	161..184	CDD:275380	10/23 (43%)
		leucine-rich repeat	185..208	CDD:275380	8/22 (36%)
		leucine-rich repeat	209..231	CDD:275380	8/22 (36%)
		leucine-rich repeat	232..255	CDD:275380	9/22 (41%)
		leucine-rich repeat	256..279	CDD:275380	7/22 (32%)
		leucine-rich repeat	280..319	CDD:275380	1/38 (3%)
		leucine-rich repeat	320..343	CDD:275380	7/22 (32%)
		LRR_8	343..402	CDD:338972	16/59 (27%)
		leucine-rich repeat	344..367	CDD:275380	5/22 (23%)
		leucine-rich repeat	368..391	CDD:275380	7/22 (32%)
		leucine-rich repeat	392..410	CDD:275380	6/20 (30%)
		leucine-rich repeat	414..435	CDD:275378	5/20 (25%)
		LRRCT	431..>472	CDD:214507	11/32 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BMFS
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X351
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810