DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14762 and Lrrn3

DIOPT Version :9

Sequence 1:	NP_001246198.1	Gene:	CG14762 / 35768	FlyBaseID:	FBgn0033250	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	NP_001258637.1	Gene:	Lrrn3 / 16981	MGIID:	106036	Length:	707	Species:	Mus musculus

Alignment Length:	512	Identity:	117/512 - (22%)
Similarity:	193/512 - (37%)	Gaps:	135/512 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 VTVVLLLQVLVMDQVLGQGPPQTQVCPEQSEIAPCICTVK----KNGLDILCETTDLAHITKSMG 74
            |.|:|.|.:..:.|.:.:...    ||:.     |.|.::    ...:.:...|.|    ...:|
Mouse     8 VHVLLGLAITTLVQAIDKKVD----CPQL-----CTCEIRPWFTPRSIYMEASTVD----CNDLG 59

  Fly    75 TLKGKSPIIFYLKLRHNNLPKLQGFVFLALDIRHLTIHNSSLAAIEENALSSLGAGLTQLDVSLN 139
            .|               |.|     ..|..|.:.|.:..:::|.||.:  :.....||.||:|.|
Mouse    60 LL---------------NFP-----ARLPADTQILLLQTNNIARIEHS--TDFPVNLTGLDLSQN 102

  Fly   140 QMKTVPSQALQHLFHLLILNLNHNKITVIHNNAFEGLETLEILTLYENKITQIDPEAFRGLEDHI 204
            .:.:|.:..:|.:..||.:.|..||:|.:......||..|:.|.:..|.::.|.|.||.||.:
Mouse   103 NLSSVTNINVQKMSQLLSVYLEENKLTELPEKCLYGLSNLQELYVNHNLLSTISPGAFIGLHN-- 165

  Fly   205 KRLNLGGNDLTNIPQKALSILSTLKKLEIQENKIRTISEGDFEGLQSLDSLILAHNMITTVPANV 269
                                   |.:|.:..|:::.|:...|:.|.:|:.|:|..|.|..:....
Mouse   166 -----------------------LLRLHLNSNRLQMINSQWFDALPNLEILMLGDNPIIRIKDMN 207

  Fly   270 FSHLTLLNSLELEGNKISVIDKDAFKGLEENLQYLRLGDNQIHTIPSEALRPLHRLRHLDLRNNN 334
            |..|..|.||.:.|..::.|..||..|| |||:.:...||::..:|..||:....|:.|||..|.
Mouse   208 FQPLVKLRSLVIAGINLTEIPDDALAGL-ENLESISFYDNRLSKVPQVALQKAVNLKFLDLNKNP 271

  Fly   335 INVLAEDAFTGFGDSLTFLNLQKNDIKVLPSLL-------------------------------F 368
            ||.:..      ||....|:|::..|..:|.|:                               |
Mouse   272 INRIRR------GDFSNMLHLKELGINNMPELVSIDSLAVDNLPDLRKIEATNNPRLSYIHPNAF 330

  Fly   369 ENLNSLETLNLQNNKLQRIPQDIMEPVIDTLRIIDITDNPLNCSCELTWFPKLLEDLKNKDDEMS 433
            ..|..||:|.|..|.|..:....:|. :..|:.|.|..||:.|.|.:.|.
Mouse   331 FRLPKLESLMLNTNALSALYHGTIES-LPNLKEISIHSNPIRCDCVIRWI--------------- 379

  Fly   434 QKKKPLCHMSLDNREYFVQAMPTEKMHCAGLNVSPSPTSGGLMRILQVNILAQIAVC 490
                   :|:..|    ::.|..:.:.|    |.|....|  ..:.||:....:.:|
Mouse   380 -------NMNKTN----IRFMEPDSLFC----VDPPEFQG--QNVRQVHFRDMMEIC 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14762	NP_001246198.1	leucine-rich repeat	85..105	CDD:275380	3/19 (16%)
		LRR_RI	93..384	CDD:238064	83/321 (26%)
		leucine-rich repeat	107..129	CDD:275380	4/21 (19%)
		leucine-rich repeat	131..154	CDD:275380	8/22 (36%)
		LRR_8	154..214	CDD:290566	17/59 (29%)
		leucine-rich repeat	155..178	CDD:275380	8/22 (36%)
		leucine-rich repeat	179..203	CDD:275380	9/23 (39%)
		leucine-rich repeat	204..227	CDD:275380	0/22 (0%)
		LRR_8	226..286	CDD:290566	17/59 (29%)
		leucine-rich repeat	228..251	CDD:275380	6/22 (27%)
		leucine-rich repeat	252..275	CDD:275380	7/22 (32%)
		LRR_8	276..335	CDD:290566	22/58 (38%)
		leucine-rich repeat	276..300	CDD:275380	9/23 (39%)
		leucine-rich repeat	301..324	CDD:275380	6/22 (27%)
		leucine-rich repeat	325..349	CDD:275380	8/23 (35%)
		LRR_8	349..409	CDD:290566	18/90 (20%)
		leucine-rich repeat	350..373	CDD:275380	7/53 (13%)
Lrrn3	NP_001258637.1	LRRNT	28..72	CDD:214470	12/76 (16%)
		LRR 1	70..91		5/22 (23%)
		leucine-rich repeat	72..93	CDD:275380	4/22 (18%)
		LRR_8	93..152	CDD:290566	19/58 (33%)
		LRR 2	93..114		7/20 (35%)
		leucine-rich repeat	94..117	CDD:275380	8/22 (36%)
		LRR 3	117..138		6/20 (30%)
		leucine-rich repeat	118..141	CDD:275380	8/22 (36%)
		LRR	139..160	CDD:197688	6/20 (30%)
		LRR 4	141..162		7/20 (35%)
		leucine-rich repeat	142..165	CDD:275380	9/22 (41%)
		LRR 5	165..186		5/45 (11%)
		leucine-rich repeat	166..189	CDD:275380	6/22 (27%)
		LRR_8	173..221	CDD:290566	14/47 (30%)
		LRR 6	189..210		6/20 (30%)
		leucine-rich repeat	190..213	CDD:275380	7/22 (32%)
		LRR_8	213..272	CDD:290566	22/59 (37%)
		LRR 7	213..234		7/20 (35%)
		leucine-rich repeat	214..237	CDD:275380	9/23 (39%)
		LRR 8	237..258		7/20 (35%)
		leucine-rich repeat	238..261	CDD:275380	6/22 (27%)
		LRR 9	261..282		9/26 (35%)
		leucine-rich repeat	262..285	CDD:275380	9/28 (32%)
		LRR 10	285..304		4/18 (22%)
		leucine-rich repeat	286..310	CDD:275380	4/23 (17%)
		LRR 11	310..332		1/21 (5%)
		LRR_8	311..370	CDD:290566	13/59 (22%)
		leucine-rich repeat	311..333	CDD:275380	1/21 (5%)
		LRR 12	335..358		7/23 (30%)
		leucine-rich repeat	336..359	CDD:275380	7/23 (30%)
		LRRCT	368..419	CDD:214507	14/82 (17%)
		I-set	429..513	CDD:254352
		Ig	440..513	CDD:299845
		fn3	526..593	CDD:278470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X351
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910