DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14762 and Lrrn2

DIOPT Version :9

Sequence 1:	NP_001246198.1	Gene:	CG14762 / 35768	FlyBaseID:	FBgn0033250	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	NP_034862.1	Gene:	Lrrn2 / 16980	MGIID:	106037	Length:	730	Species:	Mus musculus

Alignment Length:	522	Identity:	128/522 - (24%)
Similarity:	208/522 - (39%)	Gaps:	127/522 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LLLQVLVMDQVLG---QGP--PQTQVCPEQSEIAPCICTVK---------KNGLDILCETTDLAH 68
            ||:..|::..|.|   ..|  |....||.|     |.|.::         :....:.|....|..
Mouse     3 LLVAALLLSWVAGTTAAAPVVPWRVPCPPQ-----CACQIRPWYTPRSSYREATTVDCNDLFLTA 62

  Fly    69 ITKSMGTLKGKSPIIFYLKLRHNNLPKLQGFVFLALDIRHLTIHNSSLAAIEENALSSLGAGLTQ 133
            :.                       |:|..      ..:.|.:.::|::.|::..|:.| |.||:
Mouse    63 VP-----------------------PRLPA------GTQTLLLQSNSISRIDQTELAYL-ANLTE 97

  Fly   134 LDVSLNQMKTVPSQALQHLFHLLILNLNHNKITVIHNNAFEGLETLEILTLYENKITQIDPEAFR 198
            ||:|.|..........|.|..||.|:|..|::..:.:::|.||.:|:.|.|..|::.:|.|.||.
Mouse    98 LDLSQNSFSDARDCDFQALPQLLSLHLEENRLNRLEDHSFAGLTSLQELYLNHNQLCRISPRAFA 162

  Fly   199 GLEDHIKRLNLGGNDLTNIPQKALSILSTLKKLEIQENKIRTISEGDFEGLQSLDSLILAHNMIT 263
            ||          ||               |.:|.:..|.:|||....||.|.:|:.|::..|.:.
Mouse   163 GL----------GN---------------LLRLHLNSNLLRTIDSRWFEMLPNLEILMIGGNKVD 202

  Fly   264 TVPANVFSHLTLLNSLELEGNKISVIDKDAFKGLEENLQYLRLGDNQIHTIPSEALRPLHRLRHL 328
            .:....|..|..|.||.|.|..:..|...|.:|| ::|:.|...|||:..:|..||..:..|:.|
Mouse   203 AILDMNFRPLANLRSLVLAGMSLREISDYALEGL-QSLESLSFYDNQLAQVPKRALEQVPGLKFL 266

  Fly   329 DLRNNNINVLAEDAFTGFGDSLTFLNLQK---NDIKVLPSL------------------------ 366
            ||..|.:..:      |.||....|:|::   |:::.|.|:
Mouse   267 DLNKNPLQRV------GPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNPRLSF 325

  Fly   367 ----LFENLNSLETLNLQNNKLQRIPQDIMEPVIDTLRIIDITDNPLNCSCELTWFPKLLEDLKN 427
                .|.:|..:|||.|.||.|..:.|..:|. :..|:.:.:..||:.|.|.:.|     .:...
Mouse   326 IHPRAFHHLPQMETLMLNNNALSALHQQTVES-LPNLQEVGLHGNPIRCDCVIRW-----ANATG 384

  Fly   428 KDDEMSQKKKPLCHMSLDNREYFVQAMPTEKM--HCAGLNVSPS--PTS----GGLMRILQVNIL 484
            ......:.:..||....|.:...|:.:|..:|  ||..| :||.  |:|    .|...:|....|
Mouse   385 THVRFIEPQSTLCAEPPDLQRRPVREVPFREMTDHCLPL-ISPRSFPSSLQIASGESTVLHCRAL 448

  Fly   485 AQ 486
            |:
Mouse   449 AE 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14762	NP_001246198.1	leucine-rich repeat	85..105	CDD:275380	2/19 (11%)
		LRR_RI	93..384	CDD:238064	88/321 (27%)
		leucine-rich repeat	107..129	CDD:275380	5/21 (24%)
		leucine-rich repeat	131..154	CDD:275380	8/22 (36%)
		LRR_8	154..214	CDD:290566	20/59 (34%)
		leucine-rich repeat	155..178	CDD:275380	8/22 (36%)
		leucine-rich repeat	179..203	CDD:275380	10/23 (43%)
		leucine-rich repeat	204..227	CDD:275380	2/22 (9%)
		LRR_8	226..286	CDD:290566	19/59 (32%)
		leucine-rich repeat	228..251	CDD:275380	9/22 (41%)
		leucine-rich repeat	252..275	CDD:275380	5/22 (23%)
		LRR_8	276..335	CDD:290566	22/58 (38%)
		leucine-rich repeat	276..300	CDD:275380	9/23 (39%)
		leucine-rich repeat	301..324	CDD:275380	8/22 (36%)
		leucine-rich repeat	325..349	CDD:275380	7/23 (30%)
		LRR_8	349..409	CDD:290566	18/90 (20%)
		leucine-rich repeat	350..373	CDD:275380	7/53 (13%)
Lrrn2	NP_034862.1	leucine-rich repeat	51..69	CDD:275380	4/40 (10%)
		LRR_RI	62..288	CDD:238064	76/287 (26%)
		leucine-rich repeat	71..94	CDD:275380	5/23 (22%)
		leucine-rich repeat	95..118	CDD:275380	8/22 (36%)
		LRR_8	117..177	CDD:290566	23/84 (27%)
		leucine-rich repeat	119..142	CDD:275380	8/22 (36%)
		leucine-rich repeat	143..166	CDD:275380	10/32 (31%)
		LRR_8	166..222	CDD:290566	19/70 (27%)
		leucine-rich repeat	167..190	CDD:275380	9/22 (41%)
		leucine-rich repeat	191..214	CDD:275380	5/22 (23%)
		LRR_RI	214..>372	CDD:238064	44/165 (27%)
		LRR_8	214..273	CDD:290566	22/59 (37%)
		leucine-rich repeat	215..238	CDD:275380	9/23 (39%)
		leucine-rich repeat	239..262	CDD:275380	8/22 (36%)
		leucine-rich repeat	263..286	CDD:275380	8/28 (29%)
		leucine-rich repeat	287..311	CDD:275380	4/23 (17%)
		LRR_8	310..371	CDD:290566	13/61 (21%)
		leucine-rich repeat	312..334	CDD:275380	1/21 (5%)
		leucine-rich repeat	337..360	CDD:275378	9/23 (39%)
		leucine-rich repeat	361..373	CDD:275378	3/11 (27%)
		TPKR_C2	369..412	CDD:301599	9/47 (19%)
		I-set	430..514	CDD:254352	6/21 (29%)
		Ig	438..514	CDD:299845	4/13 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X351
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910