DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG14762 and LINGO2

DIOPT Version :9

Sequence 1:NP_001246198.1 Gene:CG14762 / 35768 FlyBaseID:FBgn0033250 Length:498 Species:Drosophila melanogaster
Sequence 2:NP_001245211.1 Gene:LINGO2 / 158038 HGNCID:21207 Length:606 Species:Homo sapiens


Alignment Length:485 Identity:112/485 - (23%)
Similarity:195/485 - (40%) Gaps:91/485 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 LLLQVLVMDQVLGQGPPQTQVCPEQSEIAPCICTVKKNGLDILCETTDLAHITKSMGTLKGKSPI 82
            |.:.::.|...:|        ||     |.|.|:.:..  .:.|....|..|.:.:       ||
Human    15 LAVVLIFMGSTIG--------CP-----ARCECSAQNK--SVSCHRRRLIAIPEGI-------PI 57

  Fly    83 -IFYLKLRHNNLPKLQGFVFLALDIRHLTIHNSSLAAIEENALSSLGAGLTQLDVSLNQMKTVPS 146
             ...|.|..|.|..:....|::..:                        |.::|:|.|.:..|..
Human    58 ETKILDLSKNRLKSVNPEEFISYPL------------------------LEEIDLSDNIIANVEP 98

  Fly   147 QALQHLFHLLILNLNHNKITVIHNNAFEGLETLEILTLYENKITQIDPEAFRGLEDHIKRLNLGG 211
            .|..:||:|..|.|..|::.::....|.||..|..|.:.||||..:....|:.|. ::|.|.:|.
Human    99 GAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLH-NLKSLEVGD 162

  Fly   212 NDLTNIPQKALSILSTLKKLEIQENKIRTISEGDFEGLQSLDSLILAHNMITTVPANVFSHLTLL 276
            |||..|..:|.|.|.:|::|.:::..:..:.......|:||.||.|.|..|..:|...|..|..|
Human   163 NDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHL 227

  Fly   277 NSLELE-GNKISVIDKDAFKGLEENLQYLRLGDNQIHTIPSEALRPLHRLRHLDLRNNNINVLAE 340
            ..||:: ...:.::..::..||  ||..|.:.:..:.|:|..|.:.|..|.||:|..|.|:.:..
Human   228 KHLEIDYWPLLDMMPANSLYGL--NLTSLSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPISTIEA 290

  Fly   341 DAFTGFGDSLTFLNLQKNDIKVLPSLLFENLNSLETLNLQNNKLQRIPQDIMEPVIDTLRIIDIT 405
            ..|:.. ..|..|::....::.:....|:.|..|..||:..|.|:.:.:::.... ..|.::.|.
Human   291 GMFSDL-IRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSP-RALEVLSIN 353

  Fly   406 DNPLNCSCELTWF------------------PKLLEDLKNKDDEMSQ------------KKKPLC 440
            :|||.|.|.|.|.                  |..:.:...||...:.            ::|.|.
Human   354 NNPLACDCRLLWILQRQPTLQFGGQQPMCAGPDTIRERSFKDFHSTALSFYFTCKKPKIREKKLQ 418

  Fly   441 HMSLDNREYFVQAMPTEKMHCAGLNVSPSP 470
            |:.:|..:       |.::.|:. :..|.|
Human   419 HLLVDEGQ-------TVQLECSA-DGDPQP 440

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG14762NP_001246198.1 leucine-rich repeat 85..105 CDD:275380 5/19 (26%)
LRR_RI 93..384 CDD:238064 75/291 (26%)
leucine-rich repeat 107..129 CDD:275380 0/21 (0%)
leucine-rich repeat 131..154 CDD:275380 7/22 (32%)
LRR_8 154..214 CDD:290566 19/59 (32%)
leucine-rich repeat 155..178 CDD:275380 7/22 (32%)
leucine-rich repeat 179..203 CDD:275380 8/23 (35%)
leucine-rich repeat 204..227 CDD:275380 10/22 (45%)
LRR_8 226..286 CDD:290566 16/60 (27%)
leucine-rich repeat 228..251 CDD:275380 3/22 (14%)
leucine-rich repeat 252..275 CDD:275380 9/22 (41%)
LRR_8 276..335 CDD:290566 17/59 (29%)
leucine-rich repeat 276..300 CDD:275380 5/24 (21%)
leucine-rich repeat 301..324 CDD:275380 6/22 (27%)
leucine-rich repeat 325..349 CDD:275380 7/23 (30%)
LRR_8 349..409 CDD:290566 12/59 (20%)
leucine-rich repeat 350..373 CDD:275380 4/22 (18%)
LINGO2NP_001245211.1 LRRNT 27..60 CDD:214470 11/54 (20%)
leucine-rich repeat 39..57 CDD:275380 3/26 (12%)
LRR 1 58..79 5/20 (25%)
leucine-rich repeat 59..82 CDD:275380 5/22 (23%)
LRR_8 60..117 CDD:316378 17/80 (21%)
LRR 2 82..103 6/44 (14%)
leucine-rich repeat 83..106 CDD:275380 7/22 (32%)
LRR_8 106..165 CDD:316378 19/59 (32%)
LRR 3 106..127 5/20 (25%)
leucine-rich repeat 107..130 CDD:275380 7/22 (32%)
LRR 4 130..151 7/20 (35%)
leucine-rich repeat 131..154 CDD:275380 8/23 (35%)
LRR_5 146..276 CDD:331043 37/132 (28%)
LRR 5 154..175 8/20 (40%)
leucine-rich repeat 155..178 CDD:275380 10/22 (45%)
LRR 6 178..199 2/20 (10%)
leucine-rich repeat 179..202 CDD:275380 3/22 (14%)
LRR 7 202..223 9/20 (45%)
leucine-rich repeat 203..250 CDD:275380 14/48 (29%)
LRR 8 226..247 3/20 (15%)
LRR_8 250..309 CDD:316378 16/59 (27%)
LRR 9 250..271 6/20 (30%)
leucine-rich repeat 251..274 CDD:275380 6/22 (27%)
LRR 10 274..295 7/20 (35%)
leucine-rich repeat 275..298 CDD:275380 7/23 (30%)
LRR_8 298..357 CDD:316378 12/59 (20%)
LRR 11 298..319 3/20 (15%)
leucine-rich repeat 299..322 CDD:275380 4/22 (18%)
LRR 12 322..343 5/20 (25%)
leucine-rich repeat 323..343 CDD:275380 5/19 (26%)
PCC 327..>391 CDD:188093 13/64 (20%)
I-set 410..500 CDD:254352 8/39 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X351
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

Return to query results.
Submit another query.