Protein Alignment CG14762 and LINGO2

DIOPT Version :10

• Sequence 1: NP_001246198.1
• Gene: CG14762 / 35768
• FlyBaseID: FBgn0033250
• Length: 498
• Species: Drosophila melanogaster
• Sequence 2: NP_689783.1
• Gene: LINGO2 / 158038
• HGNCID: 21207
• Length: 606
• Species: Homo sapiens
• Alignment Length: 485
• Identity: 112/485 - (23%)
• Similarity: 195/485 - (40%)
• Gaps: 91/485 - (18%)

  Fly    18 LLLQVLVMDQVLGQGPPQTQVCPEQSEIAPCICTVKKNGLDILCETTDLAHITKSMGTLKGKSPI 82
            |.:.::.|...:|        ||     |.|.|:.:..  .:.|....|..|.:.:       ||
Human    15 LAVVLIFMGSTIG--------CP-----ARCECSAQNK--SVSCHRRRLIAIPEGI-------PI 57

  Fly    83 -IFYLKLRHNNLPKLQGFVFLALDIRHLTIHNSSLAAIEENALSSLGAGLTQLDVSLNQMKTVPS 146
             ...|.|..|.|..:....|::..:                        |.::|:|.|.:..|..
Human    58 ETKILDLSKNRLKSVNPEEFISYPL------------------------LEEIDLSDNIIANVEP 98

  Fly   147 QALQHLFHLLILNLNHNKITVIHNNAFEGLETLEILTLYENKITQIDPEAFRGLEDHIKRLNLGG 211
            .|..:||:|..|.|..|::.::....|.||..|..|.:.||||..:....|:.|. ::|.|.:|.
Human    99 GAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLH-NLKSLEVGD 162

  Fly   212 NDLTNIPQKALSILSTLKKLEIQENKIRTISEGDFEGLQSLDSLILAHNMITTVPANVFSHLTLL 276
            |||..|..:|.|.|.:|::|.:::..:..:.......|:||.||.|.|..|..:|...|..|..|
Human   163 NDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHL 227

  Fly   277 NSLELE-GNKISVIDKDAFKGLEENLQYLRLGDNQIHTIPSEALRPLHRLRHLDLRNNNINVLAE 340
            ..||:: ...:.::..::..||  ||..|.:.:..:.|:|..|.:.|..|.||:|..|.|:.:..
Human   228 KHLEIDYWPLLDMMPANSLYGL--NLTSLSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPISTIEA 290

  Fly   341 DAFTGFGDSLTFLNLQKNDIKVLPSLLFENLNSLETLNLQNNKLQRIPQDIMEPVIDTLRIIDIT 405
            ..|:.. ..|..|::....::.:....|:.|..|..||:..|.|:.:.:::.... ..|.::.|.
Human   291 GMFSDL-IRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSP-RALEVLSIN 353

  Fly   406 DNPLNCSCELTWF------------------PKLLEDLKNKDDEMSQ------------KKKPLC 440
            :|||.|.|.|.|.                  |..:.:...||...:.            ::|.|.
Human   354 NNPLACDCRLLWILQRQPTLQFGGQQPMCAGPDTIRERSFKDFHSTALSFYFTCKKPKIREKKLQ 418

  Fly   441 HMSLDNREYFVQAMPTEKMHCAGLNVSPSP 470
            |:.:|..:       |.::.|:. :..|.|
Human   419 HLLVDEGQ-------TVQLECSA-DGDPQP 440

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14762	NP_001246198.1	leucine-rich repeat	85..105	CDD:275380	5/19 (26%)
		leucine-rich repeat	107..129	CDD:275380	0/21 (0%)
		LRR	<131..410	CDD:443914	78/279 (28%)
		leucine-rich repeat	131..154	CDD:275380	7/22 (32%)
		leucine-rich repeat	155..178	CDD:275380	7/22 (32%)
		leucine-rich repeat	179..203	CDD:275380	8/23 (35%)
		leucine-rich repeat	204..227	CDD:275380	10/22 (45%)
		leucine-rich repeat	228..251	CDD:275380	3/22 (14%)
		leucine-rich repeat	252..275	CDD:275380	9/22 (41%)
		leucine-rich repeat	276..300	CDD:275380	5/24 (21%)
		leucine-rich repeat	301..324	CDD:275380	6/22 (27%)
		leucine-rich repeat	325..349	CDD:275380	7/23 (30%)
		leucine-rich repeat	350..373	CDD:275380	4/22 (18%)
LINGO2	NP_689783.1	LRRNT	27..60	CDD:214470	11/54 (20%)
		leucine-rich repeat	39..57	CDD:275380	3/26 (12%)
		LRR	48..>340	CDD:443914	83/326 (25%)
		LRR 1	58..79		5/20 (25%)
		leucine-rich repeat	59..82	CDD:275380	5/22 (23%)
		LRR 2	82..103		6/44 (14%)
		leucine-rich repeat	83..106	CDD:275380	7/22 (32%)
		LRR 3	106..127		5/20 (25%)
		leucine-rich repeat	107..130	CDD:275380	7/22 (32%)
		LRR 4	130..151		7/20 (35%)
		leucine-rich repeat	131..154	CDD:275380	8/23 (35%)
		LRR 5	154..175		8/20 (40%)
		leucine-rich repeat	155..178	CDD:275380	10/22 (45%)
		LRR 6	178..199		2/20 (10%)
		leucine-rich repeat	179..202	CDD:275380	3/22 (14%)
		LRR 7	202..223		9/20 (45%)
		leucine-rich repeat	203..250	CDD:275380	14/48 (29%)
		LRR 8	226..247		3/20 (15%)
		LRR 9	250..271		6/20 (30%)
		leucine-rich repeat	251..274	CDD:275380	6/22 (27%)
		LRR 10	274..295		7/20 (35%)
		leucine-rich repeat	275..298	CDD:275380	7/23 (30%)
		LRR 11	298..319		3/20 (15%)
		leucine-rich repeat	299..322	CDD:275380	4/22 (18%)
		LRR 12	322..343		5/20 (25%)
		leucine-rich repeat	323..343	CDD:275380	5/19 (26%)
		LRRCT	355..408	CDD:214507	10/52 (19%)
		Ig	411..500	CDD:472250	8/38 (21%)
		Ig strand B	428..432	CDD:409353	0/3 (0%)
		Ig strand C	441..445	CDD:409353	112/485 (23%)
		Ig strand E	466..470	CDD:409353
		Ig strand F	480..485	CDD:409353
		Ig strand G	493..496	CDD:409353