DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14762 and Gp5

DIOPT Version :9

Sequence 1:	NP_001246198.1	Gene:	CG14762 / 35768	FlyBaseID:	FBgn0033250	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	NP_032174.2	Gene:	Gp5 / 14729	MGIID:	1096363	Length:	567	Species:	Mus musculus

Alignment Length:	474	Identity:	126/474 - (26%)
Similarity:	217/474 - (45%)	Gaps:	75/474 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LLQVLVMDQVLGQGPPQTQVCPEQSEIAPCICTVKKNGLDILCETTDLAHITKSMGTLKGKSPII 83
            :|:..::..||.....|...||:     .|.|.|:...   .|....:|||.: :|.....:.|:
Mouse     1 MLRSALLSAVLALLRAQPFPCPK-----TCKCVVRDAA---QCSGGSVAHIAE-LGLPTNLTHIL 56

  Fly    84 FYLK----LRHNNLPKLQGFVFLALDIRHLTIHNSSLAAIE----------------ENALSSLG 128
            .:..    ||:::   ..|...|    :.|.:.:|.::||:                .|.:|.|.
Mouse    57 LFRMDQGILRNHS---FSGMTVL----QRLMLSDSHISAIDPGTFNDLVKLKTLRLTRNKISRLP 114

  Fly   129 AG-------LTQLDVSLNQMKTVPSQALQHLFHLLILNLNHNKITVIHNNAFEGLETLEILTLYE 186
            ..       |.||.:..|.::.:.....|.|.:|..|.||.|:::.:..|.|..|..|::|.|..
Mouse   115 RAILDKMVLLEQLFLDHNALRDLDQNLFQQLRNLQELGLNQNQLSFLPANLFSSLRELKLLDLSR 179

  Fly   187 NKITQIDPEAFRGLEDHIKRLNLGGNDLTNIPQKALSILSTLKKLEIQENKIRTISEGDFEGLQS 251
            |.:|.: |:...|.:..:::|.|..|.||::....||.|..|.:|.::.|.:|:::.|.|:.|.:
Mouse   180 NNLTHL-PKGLLGAQVKLEKLLLYSNQLTSVDSGLLSNLGALTELRLERNHLRSVAPGAFDRLGN 243

  Fly   252 LDSLILAHNMITTVPANVFSH------LTL------------------LNSLELEGNKISVIDKD 292
            |.||.|:.|::.::|..:|.|      |||                  |..|.|.|..:|.:...
Mouse   244 LSSLTLSGNLLESLPPALFLHVSSVSRLTLFENPLEELPDVLFGEMAGLRELWLNGTHLSTLPAA 308

  Fly   293 AFKGLEENLQYLRLGDN-QIHTIPSEALRPLHRLRHLDLRNNNINVLAEDAFTGFGDSLTFLNLQ 356
            ||:.| ..||.|.|..| ::..:|....:.|..||.|.|..|.:..|.:||..|.| .|..::|:
Mouse   309 AFRNL-SGLQTLGLTRNPRLSALPRGVFQGLRELRVLALHTNALAELRDDALRGLG-HLRQVSLR 371

  Fly   357 KNDIKVLPSLLFENLNSLETLNLQNNKLQRIPQDIMEPVIDTLRIIDITDNPLNCSCELTWFPKL 421
            .|.::.||..||.||:|||::.|::|:|:.:|.|:...:....::: :..||..|.|.| |  ..
Mouse   372 HNRLRALPRTLFRNLSSLESVQLEHNQLETLPGDVFAALPQLTQVL-LGHNPWLCDCGL-W--PF 432

  Fly   422 LEDLKNKDDEMSQKKKPLC 440
            |:.|::..|.:.:.:.|.|
Mouse   433 LQWLRHHPDILGRDEPPQC 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14762	NP_001246198.1	leucine-rich repeat	85..105	CDD:275380	4/23 (17%)
		LRR_RI	93..384	CDD:238064	95/338 (28%)
		leucine-rich repeat	107..129	CDD:275380	7/37 (19%)
		leucine-rich repeat	131..154	CDD:275380	6/22 (27%)
		LRR_8	154..214	CDD:290566	18/59 (31%)
		leucine-rich repeat	155..178	CDD:275380	8/22 (36%)
		leucine-rich repeat	179..203	CDD:275380	7/23 (30%)
		leucine-rich repeat	204..227	CDD:275380	8/22 (36%)
		LRR_8	226..286	CDD:290566	22/83 (27%)
		leucine-rich repeat	228..251	CDD:275380	7/22 (32%)
		leucine-rich repeat	252..275	CDD:275380	9/28 (32%)
		LRR_8	276..335	CDD:290566	20/59 (34%)
		leucine-rich repeat	276..300	CDD:275380	8/23 (35%)
		leucine-rich repeat	301..324	CDD:275380	7/23 (30%)
		leucine-rich repeat	325..349	CDD:275380	10/23 (43%)
		LRR_8	349..409	CDD:290566	18/59 (31%)
		leucine-rich repeat	350..373	CDD:275380	9/22 (41%)
Gp5	NP_032174.2	LRR 1	75..96		5/24 (21%)
		LRR_8	76..134	CDD:290566	12/61 (20%)
		leucine-rich repeat	76..99	CDD:275380	5/26 (19%)
		LRR 2	99..120		3/20 (15%)
		leucine-rich repeat	100..123	CDD:275380	3/22 (14%)
		LRR 3	123..144		4/20 (20%)
		LRR_8	124..182	CDD:290566	18/57 (32%)
		leucine-rich repeat	124..147	CDD:275380	6/22 (27%)
		LRR_RI	126..402	CDD:238064	86/278 (31%)
		LRR 4	147..168		7/20 (35%)
		leucine-rich repeat	148..171	CDD:275380	8/22 (36%)
		LRR 5	171..193		7/22 (32%)
		leucine-rich repeat	172..195	CDD:275380	7/23 (30%)
		LRR_8	195..254	CDD:290566	20/58 (34%)
		LRR 6	195..216		6/20 (30%)
		leucine-rich repeat	196..219	CDD:275380	8/22 (36%)
		LRR 7	219..240		6/20 (30%)
		leucine-rich repeat	220..243	CDD:275380	7/22 (32%)
		LRR_8	243..302	CDD:290566	15/58 (26%)
		LRR 8	243..264		7/20 (35%)
		leucine-rich repeat	244..267	CDD:275380	8/22 (36%)
		LRR 9	267..288		3/20 (15%)
		leucine-rich repeat	268..291	CDD:275380	3/22 (14%)
		LRR 10	291..312		7/20 (35%)
		leucine-rich repeat	292..315	CDD:275380	8/23 (35%)
		LRR_8	314..375	CDD:290566	20/61 (33%)
		LRR 11	315..337		6/21 (29%)
		leucine-rich repeat	316..338	CDD:275380	6/21 (29%)
		LRR 12	340..361		8/20 (40%)
		leucine-rich repeat	341..364	CDD:275380	10/23 (43%)
		LRR_8	364..422	CDD:290566	17/58 (29%)
		LRR 13	364..385		7/20 (35%)
		leucine-rich repeat	365..388	CDD:275380	9/22 (41%)
		LRR 14	388..409		8/20 (40%)
		leucine-rich repeat	389..410	CDD:275380	7/20 (35%)
		TPKR_C2	421..>454	CDD:301599	11/34 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10028
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940