Protein Alignment CG14762 and SLITRK4

DIOPT Version :9

• Sequence 1: NP_001246198.1
• Gene: CG14762 / 35768
• FlyBaseID: FBgn0033250
• Length: 498
• Species: Drosophila melanogaster
• Sequence 2: NP_001171678.1
• Gene: SLITRK4 / 139065
• HGNCID: 23502
• Length: 837
• Species: Homo sapiens
• Alignment Length: 697
• Identity: 149/697 - (21%)
• Similarity: 225/697 - (32%)
• Gaps: 268/697 - (38%)

  Fly    12 MVVTVVLLLQVLVMDQVLGQGPPQTQVCPEQSEIAPCICTVKKNGLDILCETTDLAHITKSMGTL 76
            |.:.:.|:|..|: ...........::|      ..|.|...:|.|.:.||...:....:    |
Human     1 MFLWLFLILSALI-SSTNADSDISVEIC------NVCSCVSVENVLYVNCEKVSVYRPNQ----L 54

  Fly    77 KGKSPIIFYLKLRHNNLPKLQGFVFLALDIRH-LTIH--NSSLAAIEENALSSLGAGLTQLDVSL 138
            |......::|..::|.|..|....|  |:..| :::|  |:.|..||..|...|.| |.||.::.
Human    55 KPPWSNFYHLNFQNNFLNILYPNTF--LNFSHAVSLHLGNNKLQNIEGGAFLGLSA-LKQLHLNN 116

  Fly   139 NQMKTVPSQALQHLFHLLILNLNHNKITVIHNNAFEGLETLEILTLYENKITQIDPEAFR----- 198
            |::|.:.:.....:.:|..|..::|.|..|...||..|..|::|.|.:|.|:.:....||
Human   117 NELKILRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFRFASLT 181

  Fly   199 ---------------GLEDHIKR---LNLGGND-------------LTNIPQ------------- 219
                           |:.:||.|   |.|..|.             |.|:|.
Human   182 HLDIRGNRIQKLPYIGVLEHIGRVVELQLEDNPWNCSCDLLPLKAWLENMPYNIYIGEAICETPS 246

  Fly   220 ----------------------------------------------------------------- 219
                                                                             
Human   247 DLYGRLLKETNKQELCPMGTGSDFDVRILPPSQLENGYTTPNGHTTQTSLHRLVTKPPKTTNPSK 311

  Fly   220 -------KALS------ILS--------------------------------------------- 226
                   ||||      |:|
Human   312 ISGIVAGKALSNRNLSQIVSYQTRVPPLTPCPAPCFCKTHPSDLGLSVNCQEKNIQSMSELIPKP 376

  Fly   227 -TLKKLEIQENKIRTISEGDFEGLQSLDSLILAHNMITTVPANVFSHLTLLNSLELEGNKISVID 290
             ..|||.:..|.|:.:...||...:.||.|.|..|.||.:..:||.:||.|..|.|.||:|..:.
Human   377 LNAKKLHVNGNSIKDVDVSDFTDFEGLDLLHLGSNQITVIKGDVFHNLTNLRRLYLNGNQIERLY 441

  Fly   291 KDAFKGLEENLQYLRLGDNQIHTIPSEALRPLHRLRHLDLRNNNINVLAEDAFTGFGDSLTFLNL 355
            .:.|.|| .|||||.|..|.|..|.:.....:..|:.|.| |||:
Human   442 PEIFSGL-HNLQYLYLEYNLIKEISAGTFDSMPNLQLLYL-NNNL-------------------- 484

  Fly   356 QKNDIKVLPSLLFENLNSLETLNLQNNKLQRIPQDIMEPVIDTLRIIDITDNPLNCSCELT---- 416
                :|.||..:|... .|..|||:|||...:|...:...:.:|..||:..||.:|:|:|.
Human   485 ----LKSLPVYIFSGA-PLARLNLRNNKFMYLPVSGVLDQLQSLTQIDLEGNPWDCTCDLVALKL 544

  Fly   417 WFPKLLEDLKNKD------------DEMSQKKKPLCHMSLDNREYFVQAMPTEKMHCAGLNVSPS 469
            |..||.:.:..|:            :..|.|.:.||...|:.        |:...      .||:
Human   545 WVEKLSDGIVVKELKCETPVQFANIELKSLKNEILCPKLLNK--------PSAPF------TSPA 595

  Fly   470 PT-------------SGG-------LMRILQVNILAQ-IAVCSVAFL 495
            |.             .||       ::.||.|.||.. :|.|.:.|:
Human   596 PAITFTTPLGPIRSPPGGPVPLSILILSILVVLILTVFVAFCLLVFV 642

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14762	NP_001246198.1	leucine-rich repeat	85..105	CDD:275380	5/19 (26%)
		LRR_RI	93..384	CDD:238064	101/466 (22%)
		leucine-rich repeat	107..129	CDD:275380	8/24 (33%)
		leucine-rich repeat	131..154	CDD:275380	5/22 (23%)
		LRR_8	154..214	CDD:290566	22/95 (23%)
		leucine-rich repeat	155..178	CDD:275380	8/22 (36%)
		leucine-rich repeat	179..203	CDD:275380	8/43 (19%)
		leucine-rich repeat	204..227	CDD:275380	14/175 (8%)
		LRR_8	226..286	CDD:290566	24/105 (23%)
		leucine-rich repeat	228..251	CDD:275380	7/22 (32%)
		leucine-rich repeat	252..275	CDD:275380	10/22 (45%)
		LRR_8	276..335	CDD:290566	23/58 (40%)
		leucine-rich repeat	276..300	CDD:275380	9/23 (39%)
		leucine-rich repeat	301..324	CDD:275380	8/22 (36%)
		leucine-rich repeat	325..349	CDD:275380	6/23 (26%)
		LRR_8	349..409	CDD:290566	16/59 (27%)
		leucine-rich repeat	350..373	CDD:275380	4/22 (18%)
SLITRK4	NP_001171678.1	LRR 1	60..81		5/22 (23%)
		leucine-rich repeat	63..84	CDD:275380	6/22 (27%)
		LRR_8	83..143	CDD:316378	17/60 (28%)
		LRR 2	84..105		7/20 (35%)
		leucine-rich repeat	85..108	CDD:275380	7/22 (32%)
		LRR 3	108..129		6/21 (29%)
		leucine-rich repeat	109..132	CDD:275380	5/22 (23%)
		LRR_8	132..190	CDD:316378	15/57 (26%)
		LRR 4	132..153		7/20 (35%)
		leucine-rich repeat	133..156	CDD:275380	8/22 (36%)
		LRR 5	156..177		6/20 (30%)
		leucine-rich repeat	157..179	CDD:275380	7/21 (33%)
		LRR 6	179..200		1/20 (5%)
		leucine-rich repeat	180..204	CDD:275380	3/23 (13%)
		leucine-rich repeat	205..295	CDD:275380	6/89 (7%)
		LRRCT	213..>253	CDD:214507	4/39 (10%)
		leucine-rich repeat	296..371	CDD:275380	6/74 (8%)
		leucine-rich repeat	372..402	CDD:275380	7/29 (24%)
		LRR 7	378..399		7/20 (35%)
		LRR_8	402..461	CDD:316378	27/59 (46%)
		LRR 8	402..423		9/20 (45%)
		leucine-rich repeat	403..426	CDD:275380	10/22 (45%)
		LRR 9	426..447		7/20 (35%)
		leucine-rich repeat	427..450	CDD:275380	9/23 (39%)
		LRR 10	450..471		9/20 (45%)
		leucine-rich repeat	451..472	CDD:275380	8/20 (40%)
		LRR 11	474..495		10/45 (22%)
		leucine-rich repeat	475..496	CDD:275380	10/45 (22%)
		LRR 12	497..518		8/20 (40%)
		leucine-rich repeat	498..522	CDD:275380	8/23 (35%)
		PCC	502..>563	CDD:188093	18/60 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000