DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14762 and RXFP2

DIOPT Version :9

Sequence 1:	NP_001246198.1	Gene:	CG14762 / 35768	FlyBaseID:	FBgn0033250	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	NP_570718.1	Gene:	RXFP2 / 122042	HGNCID:	17318	Length:	754	Species:	Homo sapiens

Alignment Length:	518	Identity:	129/518 - (24%)
Similarity:	199/518 - (38%)	Gaps:	137/518 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 VVTVVLLLQVLVM----DQVLGQGPPQTQVCPEQSEIAPC-----------ICTVKK---NGLDI 59
            ::|:..||..:|:    |..|.||...|..|  |....||           .|..|.   ||.|
Human    15 LITMFFLLHFIVLINVKDFALTQGSMITPSC--QKGYFPCGNLTKCLPRAFHCDGKDDCGNGAD- 76

  Fly    60 LCETTDLAHITKSMGTLKGKSPIIFYLKLRHNNLPKLQGFVFLALDIRHLTIHN--SSLAAIEEN 122
                      .::.|...|.:.|..                         |:|.  :|:|..:|.
Human    77 ----------EENCGDTSGWATIFG-------------------------TVHGNANSVALTQEC 106

  Fly   123 ALSS----LGAGLTQLDVSLNQMKTVPSQALQHLFHLLILNLNHNKITVIHNNAFEGLETLEILT 183
            .|..    .....|:|:.....:|:||                     :|.||       :.:|:
Human   107 FLKQYPQCCDCKETELECVNGDLKSVP---------------------MISNN-------VTLLS 143

  Fly   184 LYENKITQIDPEAFRGLEDHIKRLNLGGNDLTNIPQKALSILSTLKKLEIQENKIRTISEGDFEG 248
            |.:|||             |            ::|.|.....:.|||:.:|.|.||.||...|.|
Human   144 LKKNKI-------------H------------SLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFG 183

  Fly   249 LQSLDSLILAHNMITTVPANVFSHLTLLNSLELEGNKISVIDKDAFKGLEENLQYLRLGDNQIHT 313
            |.:|..|.|.||.|||:...:|..|..|..|.|:.|.|:.|.:..|.|| .:|.:|.:.:|.:..
Human   184 LCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGL-NSLFFLSMVNNYLEA 247

  Fly   314 IPSEALRPLHRLRHLDLRNNNINVLAEDAFTGFGDSLTFLNLQKNDIKVLPSLLFENLNSLETLN 378
            :|.:....:.:|..:||..|.|..|....|... ||||.|.|.:|.|..:|...|.:|.:|..|:
Human   248 LPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSC-DSLTVLFLPRNQIGFVPEKTFSSLKNLGELD 311

  Fly   379 LQNNKLQRIPQDIMEPVIDTLRIIDITDNPL-----NCSCELTWFPKL-LE--DLKNKDDEMSQK 435
            |.:|.:..:...:.:. :..|:.::::.|||     |....|.....| ||  ::.|.:..|.|.
Human   312 LSSNTITELSPHLFKD-LKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDLERIEIPNINTRMFQP 375

  Fly   436 KKPLCHMSLDNREYFVQAMPTEKMHCAGLNVSPSPTSGGLMRI--LQVNILAQIAVCSVAFLT 496
            .|.|.|:...|..|...| |..:: |       .|.:.|:...  |..|.:.:|.|..:||:|
Human   376 MKNLSHIYFKNFRYCSYA-PHVRI-C-------MPLTDGISSFEDLLANNILRIFVWVIAFIT 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14762	NP_001246198.1	leucine-rich repeat	85..105	CDD:275380	0/19 (0%)
		LRR_RI	93..384	CDD:238064	79/296 (27%)
		leucine-rich repeat	107..129	CDD:275380	6/27 (22%)
		leucine-rich repeat	131..154	CDD:275380	5/22 (23%)
		LRR_8	154..214	CDD:290566	9/59 (15%)
		leucine-rich repeat	155..178	CDD:275380	3/22 (14%)
		leucine-rich repeat	179..203	CDD:275380	5/23 (22%)
		leucine-rich repeat	204..227	CDD:275380	2/22 (9%)
		LRR_8	226..286	CDD:290566	26/59 (44%)
		leucine-rich repeat	228..251	CDD:275380	12/22 (55%)
		leucine-rich repeat	252..275	CDD:275380	10/22 (45%)
		LRR_8	276..335	CDD:290566	17/58 (29%)
		leucine-rich repeat	276..300	CDD:275380	9/23 (39%)
		leucine-rich repeat	301..324	CDD:275380	4/22 (18%)
		leucine-rich repeat	325..349	CDD:275380	7/23 (30%)
		LRR_8	349..409	CDD:290566	16/59 (27%)
		leucine-rich repeat	350..373	CDD:275380	9/22 (41%)
RXFP2	NP_570718.1	LDLa	45..80	CDD:238060	9/47 (19%)
		LRR 1	138..159		9/52 (17%)
		leucine-rich repeat	139..162	CDD:275380	8/47 (17%)
		LRR_RI	<155..303	CDD:238064	53/149 (36%)
		LRR_8	161..221	CDD:290566	26/59 (44%)
		LRR 2	162..183		10/20 (50%)
		leucine-rich repeat	163..186	CDD:275380	12/22 (55%)
		LRR 3	186..207		9/20 (45%)
		leucine-rich repeat	187..210	CDD:275380	10/22 (45%)
		LRR 4	210..231		7/20 (35%)
		leucine-rich repeat	211..234	CDD:275380	9/23 (39%)
		LRR 5	234..255		4/20 (20%)
		leucine-rich repeat	235..258	CDD:275380	4/22 (18%)
		LRR 6	258..279		7/20 (35%)
		leucine-rich repeat	259..282	CDD:275380	7/23 (30%)
		LRR_8	282..341	CDD:290566	16/59 (27%)
		LRR 7	282..303		9/20 (45%)
		leucine-rich repeat	283..306	CDD:275380	9/22 (41%)
		LRR_4	305..>341	CDD:289563	6/36 (17%)
		LRR 8	306..327		4/20 (20%)
		leucine-rich repeat	307..330	CDD:275380	4/23 (17%)
		LRR 9	330..351		5/20 (25%)
		LRR_8	331..383	CDD:290566	15/51 (29%)
		leucine-rich repeat	331..354	CDD:275380	6/22 (27%)
		LRR 10	354..375		5/20 (25%)
		leucine-rich repeat	355..374	CDD:275380	5/18 (28%)
		7tm_4	424..>628	CDD:304433	3/6 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910