Protein Alignment CG14762 and SLITRK1

DIOPT Version :10

• Sequence 1: NP_001246198.1
• Gene: CG14762 / 35768
• FlyBaseID: FBgn0033250
• Length: 498
• Species: Drosophila melanogaster
• Sequence 2: NP_443142.1
• Gene: SLITRK1 / 114798
• HGNCID: 20297
• Length: 696
• Species: Homo sapiens
• Alignment Length: 678
• Identity: 144/678 - (21%)
• Similarity: 223/678 - (32%)
• Gaps: 245/678 - (36%)

  Fly    18 LLLQVLVMDQVL--GQGPPQTQVCPEQSEIAPCICTVKKNGLDILCE-------------TTDLA 67
            :||.:|:::..|  ..|.....||.|:.    |.|...:..|.:.||             |:...
Human     1 MLLWILLLETSLCFAAGNVTGDVCKEKI----CSCNEIEGDLHVDCEKKGFTSLQRFTAPTSQFY 61

  Fly    68 HITKSMGTLKGKSP---IIFY----LKLRHNNLPKLQGFVFLALD-IRHLTIHNSSLAAIEENAL 124
            |:.....:|....|   ..||    |.:.:|.|.::....||.|. ::.|.|:|:.:.:..:...
Human    62 HLFLHGNSLTRLFPNEFANFYNAVSLHMENNGLHEIVPGAFLGLQLVKRLHINNNKIKSFRKQTF 126

  Fly   125 SSLGAGLTQLDVSLNQMKTVPSQALQHLFHLLILNLNHNKITVIHNNAF---------------- 173
            ..|. .|..|....|.::.:...|.|.|..|.:|.||.|.|:.:..|.|
Human   127 LGLD-DLEYLQADFNLLRDIDPGAFQDLNKLEVLILNDNLISTLPANVFQYVPITHLDLRGNRLK 190

  Fly   174 -----EGLE-----------------TLEILTLYE---------------------------NKI 189
                 |.||                 |.::|:|.|                           |:.
Human   191 TLPYEEVLEQIPGIAEILLEDNPWDCTCDLLSLKEWLENIPKNALIGRVVCEAPTRLQGKDLNET 255

  Fly   190 TQID---------------------------PEAFR--GLEDHIK---------------RLNL- 209
            |:.|                           |..|:  |.|||..               ::.:
Human   256 TEQDLCPLKNRVDSSLPAPPAQEETFAPGPLPTPFKTNGQEDHATPGSAPNGGTKIPGNWQIKIR 320

  Fly   210 ----------------------GGNDLTNIPQKALSI----------------LSTLKKLEIQEN 236
                                  ||....:||...|.:                ||.:::|.:::|
Human   321 PTAAIATGSSRNKPLANSLPCPGGCSCDHIPGSGLKMNCNNRNVSSLADLKPKLSNVQELFLRDN 385

  Fly   237 KIRTISEGDFEGLQSLDSLILAHNMITTVPANVFSHLTLLNSLELEGNKISVIDKDAFKGLEENL 301
            ||.:|.:..|...::|..|.|.:|.|.||..|.|.:|..|..|.::.|.:..:.::.|.|| :||
Human   386 KIHSIRKSHFVDYKNLILLDLGNNNIATVENNTFKNLLDLRWLYMDSNYLDTLSREKFAGL-QNL 449

  Fly   302 QYLRLGDNQIHTIPSEALRPLHRLRHLDLRNNNINVLAEDAFTGFGDSLTFLNLQKNDIKVLPSL 366
            :||.:..|.|..|.......:.:||.|.|.||.:..|..|.|.|.
Human   450 EYLNVEYNAIQLILPGTFNAMPKLRILILNNNLLRSLPVDVFAGV-------------------- 494

  Fly   367 LFENLNSLETLNLQNNKLQRIPQDIMEPVIDTLRI---IDITDNPLNCSCELTWFPK-------- 420
                  ||..|:|.||....:|   :..|:|.|..   ||:..||..|||.:..|.:
Human   495 ------SLSKLSLHNNYFMYLP---VAGVLDQLTSIIQIDLHGNPWECSCTIVPFKQWAERLGSE 550

  Fly   421 -LLEDLK--------NKDDEMSQKKKPLCHMSLDNRE----YFVQAMPTEKMH---CAGLNVSPS 469
             |:.|||        .||           .|.|.|.|    .:.:..||...|   ..|| ....
Human   551 VLMSDLKCETPVNFFRKD-----------FMLLSNDEICPQLYARISPTLTSHSKNSTGL-AETG 603

  Fly   470 PTSGGLMRILQVNILAQIAVCSVAFLTS 497
            ..|...:...:|:|...:....:.|:||
Human   604 THSNSYLDTSRVSISVLVPGLLLVFVTS 631

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14762	NP_001246198.1	leucine-rich repeat	85..105	CDD:275380	6/23 (26%)
		leucine-rich repeat	107..129	CDD:275380	4/21 (19%)
		LRR	<131..410	CDD:443914	90/429 (21%)
		leucine-rich repeat	131..154	CDD:275380	6/22 (27%)
		leucine-rich repeat	155..178	CDD:275380	11/60 (18%)
		leucine-rich repeat	179..203	CDD:275380	10/79 (13%)
		leucine-rich repeat	204..227	CDD:275380	6/76 (8%)
		leucine-rich repeat	228..251	CDD:275380	6/22 (27%)
		leucine-rich repeat	252..275	CDD:275380	10/22 (45%)
		leucine-rich repeat	276..300	CDD:275380	6/23 (26%)
		leucine-rich repeat	301..324	CDD:275380	6/22 (27%)
		leucine-rich repeat	325..349	CDD:275380	10/23 (43%)
		leucine-rich repeat	350..373	CDD:275380	0/22 (0%)
SLITRK1	NP_443142.1	leucine-rich repeat	62..83	CDD:275380	4/20 (20%)
		LRR	<63..>212	CDD:443914	31/149 (21%)
		leucine-rich repeat	86..107	CDD:275380	6/20 (30%)
		leucine-rich repeat	108..131	CDD:275380	4/23 (17%)
		leucine-rich repeat	132..155	CDD:275380	6/22 (27%)
		leucine-rich repeat	156..171	CDD:275380	6/14 (43%)
		leucine-rich repeat	179..237	CDD:275380	7/57 (12%)
		LRRCT	212..>250	CDD:214507	4/37 (11%)
		leucine-rich repeat	356..372	CDD:275380	0/15 (0%)
		LRR	<358..>530	CDD:443914	53/201 (26%)
		leucine-rich repeat	377..400	CDD:275380	6/22 (27%)
		leucine-rich repeat	401..424	CDD:275380	10/22 (45%)
		leucine-rich repeat	425..448	CDD:275380	6/23 (26%)
		leucine-rich repeat	449..472	CDD:275380	6/22 (27%)
		leucine-rich repeat	473..495	CDD:275380	10/47 (21%)
		leucine-rich repeat	496..520	CDD:275380	9/26 (35%)
		LRRCT	529..579	CDD:214507	16/60 (27%)