DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14762 and LRRN2

DIOPT Version :9

Sequence 1:	NP_001246198.1	Gene:	CG14762 / 35768	FlyBaseID:	FBgn0033250	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	NP_006329.2	Gene:	LRRN2 / 10446	HGNCID:	16914	Length:	713	Species:	Homo sapiens

Alignment Length:	529	Identity:	126/529 - (23%)
Similarity:	206/529 - (38%)	Gaps:	142/529 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SGCTMVVTVVLLLQVLVMDQVLGQGPPQTQVCPEQSEIAPCICTVK---------KNGLDILCET 63
            :|.|..|.||                |....||.|     |.|.::         :....:.|..
Human    14 AGATAAVPVV----------------PWHVPCPPQ-----CACQIRPWYTPRSSYREATTVDCND 57

  Fly    64 TDLAHITKSM--GTLKGKSPIIFYLKLRHNNLPKLQGFVFLALDIRHLTIHNSSLAAIEENALSS 126
            ..|..:..::  ||                               :.|.:.::|:..::::.|..
Human    58 LFLTAVPPALPAGT-------------------------------QTLLLQSNSIVRVDQSELGY 91

  Fly   127 LGAGLTQLDVSLNQMKTVPSQALQHLFHLLILNLNHNKITVIHNNAFEGLETLEILTLYENKITQ 191
            | |.||:||:|.|............|..||.|:|..|::|.:.:::|.||.:|:.|.|..|::.:
Human    92 L-ANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYR 155

  Fly   192 IDPEAFRGLEDHIKRLNLGGNDLTNIPQKALSILSTLKKLEIQENKIRTISEGDFEGLQSLDSLI 256
            |.|.||.|| .::.||:|..|.|..|..:...:|..|:.|.|..||:..|.:.:|..|.:|.||:
Human   156 IAPRAFSGL-SNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLV 219

  Fly   257 LAHNMITTVPANVFSHLTLLNSLELEGNKISVIDKDAFKGLEENLQYLRLGDNQIHTIPSEALRP 321
            ||                        |..:..|...|.:|| ::|:.|...|||:..:|..||..
Human   220 LA------------------------GMNLREISDYALEGL-QSLESLSFYDNQLARVPRRALEQ 259

  Fly   322 LHRLRHLDLRNNNINVLAEDAFTGFGDSLTFLNLQK---NDIKVLPSL----------------- 366
            :..|:.|||..|.:..:      |.||....|:|::   |:::.|.|:
Human   260 VPGLKFLDLNKNPLQRV------GPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDIT 318

  Fly   367 -----------LFENLNSLETLNLQNNKLQRIPQDIMEPVIDTLRIIDITDNPLNCSCELTWFPK 420
                       .|.:|..:|||.|.||.|..:.|..:|. :..|:.:.:..||:.|.|.:.|
Human   319 NNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVES-LPNLQEVGLHGNPIRCDCVIRW--- 379

  Fly   421 LLEDLKNKDDEMSQKKKPLCHMSLDNREYFVQAMPTEKM--HCAGLNVSPS--PTS----GGLMR 477
              .:.........:.:..||....|.:...|:.:|..:|  ||..| :||.  |.|    .|...
Human   380 --ANATGTRVRFIEPQSTLCAEPPDLQRLPVREVPFREMTDHCLPL-ISPRSFPPSLQVASGESM 441

  Fly   478 ILQVNILAQ 486
            :|....||:
Human   442 VLHCRALAE 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14762	NP_001246198.1	leucine-rich repeat	85..105	CDD:275380	0/19 (0%)
		LRR_RI	93..384	CDD:238064	85/321 (26%)
		leucine-rich repeat	107..129	CDD:275380	4/21 (19%)
		leucine-rich repeat	131..154	CDD:275380	7/22 (32%)
		LRR_8	154..214	CDD:290566	23/59 (39%)
		leucine-rich repeat	155..178	CDD:275380	9/22 (41%)
		leucine-rich repeat	179..203	CDD:275380	10/23 (43%)
		leucine-rich repeat	204..227	CDD:275380	7/22 (32%)
		LRR_8	226..286	CDD:290566	14/59 (24%)
		leucine-rich repeat	228..251	CDD:275380	8/22 (36%)
		leucine-rich repeat	252..275	CDD:275380	5/22 (23%)
		LRR_8	276..335	CDD:290566	18/58 (31%)
		leucine-rich repeat	276..300	CDD:275380	5/23 (22%)
		leucine-rich repeat	301..324	CDD:275380	8/22 (36%)
		leucine-rich repeat	325..349	CDD:275380	7/23 (30%)
		LRR_8	349..409	CDD:290566	18/90 (20%)
		leucine-rich repeat	350..373	CDD:275380	7/53 (13%)
LRRN2	NP_006329.2	leucine-rich repeat	51..69	CDD:275380	2/17 (12%)
		LRR_RI	62..288	CDD:238064	75/289 (26%)
		LRR 1	70..91		5/51 (10%)
		leucine-rich repeat	71..94	CDD:275380	5/54 (9%)
		LRR 2	94..115		6/20 (30%)
		leucine-rich repeat	95..118	CDD:275380	7/22 (32%)
		LRR_8	117..177	CDD:290566	23/60 (38%)
		LRR 3	118..139		7/20 (35%)
		leucine-rich repeat	119..142	CDD:275380	9/22 (41%)
		LRR 4	142..163		8/20 (40%)
		leucine-rich repeat	143..166	CDD:275380	10/23 (43%)
		LRR_8	165..222	CDD:290566	20/80 (25%)
		LRR 5	166..187		6/20 (30%)
		leucine-rich repeat	167..190	CDD:275380	7/22 (32%)
		LRR 6	190..211		7/20 (35%)
		leucine-rich repeat	191..214	CDD:275380	8/22 (36%)
		LRR_RI	209..>372	CDD:238064	47/194 (24%)
		LRR_8	214..273	CDD:290566	23/83 (28%)
		LRR 7	214..235		8/44 (18%)
		leucine-rich repeat	215..238	CDD:275380	10/47 (21%)
		LRR 8	238..259		8/20 (40%)
		leucine-rich repeat	239..262	CDD:275380	8/22 (36%)
		LRR 9	262..283		8/26 (31%)
		leucine-rich repeat	263..286	CDD:275380	8/28 (29%)
		LRR 10	286..305		4/18 (22%)
		leucine-rich repeat	287..311	CDD:275380	4/23 (17%)
		LRR_8	310..371	CDD:290566	13/61 (21%)
		LRR 11	311..333		1/21 (5%)
		leucine-rich repeat	312..334	CDD:275380	1/21 (5%)
		LRR 12	336..357		8/20 (40%)
		leucine-rich repeat	337..360	CDD:275378	9/23 (39%)
		leucine-rich repeat	361..373	CDD:275378	3/11 (27%)
		TPKR_C2	369..412	CDD:301599	9/47 (19%)
		I-set	430..514	CDD:254352	6/21 (29%)
		Ig	438..514	CDD:299845	4/13 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X351
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910