DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14762 and lrrn3a

DIOPT Version :9

Sequence 1:	NP_001246198.1	Gene:	CG14762 / 35768	FlyBaseID:	FBgn0033250	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	XP_005163128.1	Gene:	lrrn3a / 101887059	ZFINID:	ZDB-GENE-061220-7	Length:	691	Species:	Danio rerio

Alignment Length:	419	Identity:	103/419 - (24%)
Similarity:	174/419 - (41%)	Gaps:	96/419 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 LALDIRHLTIHNSSLAAIEENALSSLGAGLTQLDVSLNQMKTVPSQALQHLFHLLILNLNHNKIT 166
            |..|.:.|....:|:|.| ::.|..| ..||::|:|.|.:.::....:.|:..||.|:|..|.::
Zfish    67 LPSDTQVLLSQANSIAKI-DSPLDYL-VNLTEVDLSRNNISSLSDIYIGHIPQLLSLHLEENWLS 129

  Fly   167 VIHNNAFEGLETLEILTLYENKITQIDPEAFRGLEDHIKRLNLGGNDLTNIPQKALSILSTLKKL 231
            .:|:|.......|:.|.:..|.::.|..|||:|| :.:.||:|..|.|..|..:....||.|:.|
Zfish   130 SLHDNFLAHFPNLQELYVNHNLLSLISAEAFQGL-NKLLRLHLNSNQLRAIRSEWFQDLSQLEIL 193

  Fly   232 EIQENKIRTISEGDFEGLQSLDSLILAHNMITTVPANVFSHLTLLNSLELEGNKISVIDKDAFKG 296
            .|.||.|..|...:|:.|.:|.||:|....:|.:|                        ..|..|
Zfish   194 MIGENPIARIQNMNFKPLINLRSLVLTRMNLTEIP------------------------DSALVG 234

  Fly   297 LEENLQYLRLGDNQIHTIPSEALRPLHRLRHLDLRNNNINVLAEDAFTGFGDSLTFLNLQKNDIK 361
            |:: |:.:...||....:|..|||.:..|:.|||..|.|..:..      ||.:..::|::..|.
Zfish   235 LDK-LESVSFYDNMFPKVPQAALRQVRNLKFLDLNKNPIERIQR------GDFVDMIHLKELGIN 292

  Fly   362 VLPSLL-------------------------------FENLNSLETLNLQNNKLQRIPQDIMEPV 395
            .:|.|:                               |..|..||:|.|.:|.|:.:....:|.
Zfish   293 SMPELVSIDSFALHNLPELTKIEATNNPRLSYIHPNAFSQLPRLESLMLNSNALRALHHITVES- 356

  Fly   396 IDTLRIIDITDNPLNCSCELTWFPKLLEDLKNKDDEMSQKKKPLCHMSLDNREYFVQAMPTEKMH 460
            :..|:.:.|..||:.|.|.:.|                        ::::|..  |:.|..:.:.
Zfish   357 LPNLQEVSIHSNPIYCDCVIRW------------------------INMNNTR--VRFMELDALL 395

  Fly   461 CAGLNVSPSPTSGGLMRILQVNILAQIAV 489
            |||    ||...|.|::.:....:|.|.:
Zfish   396 CAG----PSEFEGRLVKQVHSREMADICL 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14762	NP_001246198.1	leucine-rich repeat	85..105	CDD:275380	1/2 (50%)
		LRR_RI	93..384	CDD:238064	82/312 (26%)
		leucine-rich repeat	107..129	CDD:275380	6/21 (29%)
		leucine-rich repeat	131..154	CDD:275380	6/22 (27%)
		LRR_8	154..214	CDD:290566	20/59 (34%)
		leucine-rich repeat	155..178	CDD:275380	7/22 (32%)
		leucine-rich repeat	179..203	CDD:275380	9/23 (39%)
		leucine-rich repeat	204..227	CDD:275380	7/22 (32%)
		LRR_8	226..286	CDD:290566	16/59 (27%)
		leucine-rich repeat	228..251	CDD:275380	9/22 (41%)
		leucine-rich repeat	252..275	CDD:275380	6/22 (27%)
		LRR_8	276..335	CDD:290566	15/58 (26%)
		leucine-rich repeat	276..300	CDD:275380	3/23 (13%)
		leucine-rich repeat	301..324	CDD:275380	7/22 (32%)
		leucine-rich repeat	325..349	CDD:275380	7/23 (30%)
		LRR_8	349..409	CDD:290566	16/90 (18%)
		leucine-rich repeat	350..373	CDD:275380	6/53 (11%)
lrrn3a	XP_005163128.1	LRR_RI	29..>272	CDD:238064	68/232 (29%)
		leucine-rich repeat	52..70	CDD:275380	1/2 (50%)
		leucine-rich repeat	71..93	CDD:275380	6/23 (26%)
		leucine-rich repeat	94..117	CDD:275380	6/22 (27%)
		leucine-rich repeat	118..141	CDD:275380	7/22 (32%)
		LRR_8	140..200	CDD:290566	22/60 (37%)
		leucine-rich repeat	142..165	CDD:275380	9/23 (39%)
		leucine-rich repeat	166..189	CDD:275380	7/22 (32%)
		leucine-rich repeat	190..213	CDD:275380	9/22 (41%)
		LRR_8	213..272	CDD:290566	21/83 (25%)
		leucine-rich repeat	214..237	CDD:275380	9/46 (20%)
		leucine-rich repeat	238..261	CDD:275380	7/22 (32%)
		leucine-rich repeat	262..285	CDD:275380	8/28 (29%)
		leucine-rich repeat	286..310	CDD:275380	4/23 (17%)
		LRR_8	309..370	CDD:290566	12/61 (20%)
		leucine-rich repeat	311..333	CDD:275380	1/21 (5%)
		leucine-rich repeat	336..359	CDD:275378	7/23 (30%)
		leucine-rich repeat	360..372	CDD:275378	4/11 (36%)
		LRRCT	368..412	CDD:214507	15/73 (21%)
		IG_like	429..513	CDD:214653
		Ig	437..513	CDD:299845
		FN3	526..>591	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X351
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910