DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14762 and slitrk4

DIOPT Version :9

Sequence 1:	NP_001246198.1	Gene:	CG14762 / 35768	FlyBaseID:	FBgn0033250	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	XP_004916941.2	Gene:	slitrk4 / 100497316	XenbaseID:	XB-GENE-983538	Length:	851	Species:	Xenopus tropicalis

Alignment Length:	667	Identity:	143/667 - (21%)
Similarity:	221/667 - (33%)	Gaps:	248/667 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 PQTQVCPEQSEIAPCICTVKKNGLDILCETTDLAHITKSMGTLKGKSPIIFYLKLRHNNLPKLQG 98
            |.:::..|...:  |.|...:|.:.:.||...|....:    ||......::|..::|.|..|..
Frog    33 PDSELSLEICNV--CSCLSVENVMYVNCEKVALYRPNQ----LKPPPSNFYHLNFQNNLLIILYP 91

  Fly    99 FVFLALDIRH---LTIHNSSLAAIEENALSSLGAGLTQLDVSLNQMKTVPSQALQHLFHLLILNL 160
            ..|  |:..|   |.:.|:.|..||..|...|.| |.||.::.|::|.:.:.....:.:|..|..
Frog    92 NTF--LNFTHAVSLQLGNNKLQNIEGGAFQGLSA-LKQLHLNNNELKVLRADTFLGIENLEYLQA 153

  Fly   161 NHNKITVIHNNAFEGLETLEILTLYENKITQIDPEAFR--------------------GLEDHIK 205
            ::|.|..|...||..|..|::|.|.:|.|:.:....||                    |:.:||.
Frog   154 DYNLIKYIERGAFNKLHKLKVLILNDNLISALPDNIFRFASLTHLDIRGNRIQKMPYIGVLEHIG 218

  Fly   206 RL---------------------------------------------------------NLG-GN 212
            |:                                                         ::| |:
Frog   219 RVVELQLEDNPWNCTCDLLPLKAWLENMPYNIYIGEAICETPSDLYGRLLKETNKQELCSMGTGS 283

  Fly   213 DL----------------------------------TNIPQKALSILS----------------- 226
            |.                                  |..|.|...|:|
Frog   284 DFDVRILPPSMETTFTTPGGQPAQTSLHRLVTKAPKTTNPSKNSGIVSGKSVSNHSLSQIVSFQT 348

  Fly   227 -------------------------------------------TLKKLEIQENKIRTISEGDFEG 248
                                                       ..|||.:..|.|:.:.:.||..
Frog   349 RIPPFSPCPSPCMCKTYPSDLGLSVNCQERNIKSMAELIPKPLNAKKLHVNGNYIKHVEQSDFVD 413

  Fly   249 LQSLDSLILAHNMITTVPANVFSHLTLLNSLELEGNKISVIDKDAFKGLEENLQYLRLGDNQIHT 313
            .:.||.|.|..|.:|.:..|||.:||.|..|.|.||:|..:..:.|.|| .|||||.|..|.|..
Frog   414 FEGLDLLHLGSNQLTNIQGNVFCNLTNLRRLYLNGNQIERLSPEIFAGL-HNLQYLYLEYNIIKE 477

  Fly   314 IPSEALRPLHRLRHLDLRNNNINVLAEDAFTGFGDSLTFLNLQKNDIKVLPSLLFENLNSLETLN 378
            |.......:..|:.|.| |||:                        ::.||:.:|..: .|..||
Frog   478 ILGGTFESMPNLQLLYL-NNNL------------------------LRSLPAYIFSGV-PLARLN 516

  Fly   379 LQNNKLQRIPQDIMEPVIDTLRI---IDITDNPLNCSCELT----WFPKLLEDLKNKD------- 429
            ::||....:|   :..|:|.||.   ||:..||.:|:|:|.    |..||.|.:..|:
Frog   517 IRNNHFMYLP---VSGVLDQLRSLTQIDLEGNPWDCTCDLVALKLWLEKLSEGIVMKEVKCETPV 578

  Fly   430 -----DEMSQKKKPLCHMSLDN--REY--------FVQAMPTEKMHCAGLNVSPSPTSGGLMRIL 479
                 :..|.|.:.||...::.  .:|        |...:...|....|    |.|.|..::.||
Frog   579 QFANIELRSLKNEILCPKLINKPPTQYTSPVPAVTFTTPLGPIKSPPGG----PVPLSILILSIL 639

  Fly   480 QVNILAQ-IAVCSVAFL 495
            .|.||.. :|.|.:.|:
Frog   640 VVLILTVFVAFCLLVFV 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14762	NP_001246198.1	leucine-rich repeat	85..105	CDD:275380	5/19 (26%)
		LRR_RI	93..384	CDD:238064	95/465 (20%)
		leucine-rich repeat	107..129	CDD:275380	8/24 (33%)
		leucine-rich repeat	131..154	CDD:275380	5/22 (23%)
		LRR_8	154..214	CDD:290566	21/137 (15%)
		leucine-rich repeat	155..178	CDD:275380	8/22 (36%)
		leucine-rich repeat	179..203	CDD:275380	8/43 (19%)
		leucine-rich repeat	204..227	CDD:275380	10/174 (6%)
		LRR_8	226..286	CDD:290566	24/119 (20%)
		leucine-rich repeat	228..251	CDD:275380	7/22 (32%)
		leucine-rich repeat	252..275	CDD:275380	10/22 (45%)
		LRR_8	276..335	CDD:290566	23/58 (40%)
		leucine-rich repeat	276..300	CDD:275380	9/23 (39%)
		leucine-rich repeat	301..324	CDD:275380	8/22 (36%)
		leucine-rich repeat	325..349	CDD:275380	6/23 (26%)
		LRR_8	349..409	CDD:290566	16/62 (26%)
		leucine-rich repeat	350..373	CDD:275380	3/22 (14%)
slitrk4	XP_004916941.2	internalin_A	<30..>268	CDD:380193	49/243 (20%)
		leucine-rich repeat	78..99	CDD:275380	6/22 (27%)
		LRR_8	102..158	CDD:404697	16/56 (29%)
		leucine-rich repeat	102..123	CDD:275380	7/20 (35%)
		leucine-rich repeat	124..147	CDD:275380	5/22 (23%)
		LRR_8	147..205	CDD:404697	15/57 (26%)
		leucine-rich repeat	148..171	CDD:275380	8/22 (36%)
		leucine-rich repeat	172..194	CDD:275380	7/21 (33%)
		leucine-rich repeat	195..219	CDD:275380	3/23 (13%)
		leucine-rich repeat	220..312	CDD:275380	3/91 (3%)
		leucine-rich repeat	313..416	CDD:275380	12/102 (12%)
		leucine-rich repeat	372..392	CDD:275380	0/19 (0%)
		PPP1R42	373..546	CDD:411060	57/202 (28%)
		LRR_8	416..473	CDD:404697	26/57 (46%)
		leucine-rich repeat	417..440	CDD:275380	10/22 (45%)
		leucine-rich repeat	441..464	CDD:275380	9/23 (39%)
		leucine-rich repeat	465..486	CDD:275380	8/20 (40%)
		leucine-rich repeat	489..510	CDD:275380	9/45 (20%)
		leucine-rich repeat	512..536	CDD:275380	9/26 (35%)
		TPKR_C2	545..>577	CDD:417692	10/31 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000