DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14762 and lingo2

DIOPT Version :9

Sequence 1:	NP_001246198.1	Gene:	CG14762 / 35768	FlyBaseID:	FBgn0033250	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	XP_004910881.1	Gene:	lingo2 / 100490134	XenbaseID:	XB-GENE-922286	Length:	612	Species:	Xenopus tropicalis

Alignment Length:	487	Identity:	121/487 - (24%)
Similarity:	185/487 - (37%)	Gaps:	124/487 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAGIQLQSG--CTMVVTVVLLLQVLVMDQVLGQGPPQTQVCPEQSEIAPCICTVKKNGLDILCET 63
            |.|:.|.:.  |..::.:|.:|.|. |....|        ||     |.|.|:.:..  .:.|..
Frog     1 MGGVMLHTATPCWHILCLVAMLLVF-MGSAFG--------CP-----AKCECSAQNK--SVSCHR 49

  Fly    64 TDLAHITKSMGTLKGKSPI-IFYLKLRHNNLPKLQGFVFLALDIRHLTIHNSSLAAIEENALSSL 127
            ..|..|.:.:       || ...|.|..|.|..:....|::..:
Frog    50 RRLVTIPEGI-------PIETKILDLSKNKLKSVNPVDFVSYPL--------------------- 86

  Fly   128 GAGLTQLDVSLNQMKTVPSQALQHLFHLLILNLNHNKITVIHNNAFEGLETLEILTLYENKITQI 192
               |..:|:|.|.:..|...|...||:|..|:|..|::.::....|.||..|..|.:.||||..:
Frog    87 ---LEDIDLSDNIISNVEPGAFNSLFNLRSLSLKGNRLKLVPLGVFTGLSNLTKLDISENKIVIL 148

  Fly   193 DPEAFRGLEDHIKRLNLGGNDLTNIPQKALSILSTLKKLEIQENKIRTISEGDFEGLQSLDSLIL 257
            ....|:.|.                         :||.||:.:|::..||...|.||.||:.|.|
Frog   149 LDYMFQDLH-------------------------SLKSLEVGDNELVYISHRAFSGLVSLEQLTL 188

  Fly   258 AHNMITTVPANVFSHLTLLNSLELEGNKISVIDKDAFKGLEE----------------------- 299
            ....:|.||.:..|||..|.||.|:...|:|:...|||.|..
Frog   189 EKCNLTAVPTDALSHLHNLYSLHLKYLNINVLPPFAFKRLFHLKILEISYWPLLDLVPANSLYGL 253

  Fly   300 NLQYLRLGDNQIHTIPSEALRPLHRLRHLDLRNNNINVLAEDAFTGFGDSLTFLNLQKNDIKVLP 364
            ||.:|.:.:..:.|||..||:.|..|.||:|..|.|.::....|:.. ..|..|:|....::.:.
Frog   254 NLTFLSITNTNLSTIPYHALKHLIYLTHLNLSYNPIGIIDTGVFSDL-VRLQELHLVGAQLRTIE 317

  Fly   365 SLLFENLNSLETLNLQNNKLQRIPQDIMEPVIDTLRIIDITDNPLNCSCELTWFPKLLEDLKNKD 429
            ...|:.|..|..||:..|.|:.:.::..:.. ..|.::.|.||||.|.|.|.|
Frog   318 PHAFQGLRFLRLLNVSQNLLETLEENAFQSP-KALEVLCIDDNPLVCDCRLIW------------ 369

  Fly   430 DEMSQK--------KKPLCHM--SLDNREYFV 451
              |.|:        ::|:|..  ||....|.|
Frog   370 --MLQRHPMLHFGGQQPMCSSPDSLKESSYKV 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14762	NP_001246198.1	leucine-rich repeat	85..105	CDD:275380	5/19 (26%)
		LRR_RI	93..384	CDD:238064	80/313 (26%)
		leucine-rich repeat	107..129	CDD:275380	0/21 (0%)
		leucine-rich repeat	131..154	CDD:275380	7/22 (32%)
		LRR_8	154..214	CDD:290566	15/59 (25%)
		leucine-rich repeat	155..178	CDD:275380	7/22 (32%)
		leucine-rich repeat	179..203	CDD:275380	8/23 (35%)
		leucine-rich repeat	204..227	CDD:275380	0/22 (0%)
		LRR_8	226..286	CDD:290566	24/59 (41%)
		leucine-rich repeat	228..251	CDD:275380	10/22 (45%)
		leucine-rich repeat	252..275	CDD:275380	9/22 (41%)
		LRR_8	276..335	CDD:290566	24/81 (30%)
		leucine-rich repeat	276..300	CDD:275380	10/46 (22%)
		leucine-rich repeat	301..324	CDD:275380	8/22 (36%)
		leucine-rich repeat	325..349	CDD:275380	7/23 (30%)
		LRR_8	349..409	CDD:290566	14/59 (24%)
		leucine-rich repeat	350..373	CDD:275380	5/22 (23%)
lingo2	XP_004910881.1	LRRNT	31..64	CDD:214470	11/54 (20%)
		leucine-rich repeat	43..61	CDD:275380	3/26 (12%)
		leucine-rich repeat	63..86	CDD:275380	5/22 (23%)
		internalin_A	<66..>285	CDD:380193	70/267 (26%)
		leucine-rich repeat	87..110	CDD:275380	7/22 (32%)
		leucine-rich repeat	111..134	CDD:275380	7/22 (32%)
		leucine-rich repeat	135..158	CDD:275380	8/47 (17%)
		leucine-rich repeat	159..182	CDD:275380	10/22 (45%)
		leucine-rich repeat	183..206	CDD:275380	9/22 (41%)
		leucine-rich repeat	207..254	CDD:275380	10/46 (22%)
		leucine-rich repeat	255..278	CDD:275380	8/22 (36%)
		LRR_8	279..337	CDD:338972	16/58 (28%)
		leucine-rich repeat	279..302	CDD:275380	7/23 (30%)
		leucine-rich repeat	303..326	CDD:275380	5/22 (23%)
		leucine-rich repeat	327..347	CDD:275380	5/19 (26%)
		TPKR_C2	359..402	CDD:387596	15/55 (27%)
		Ig	429..504	CDD:386229
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X351
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000