DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG14762 and LRRC70

DIOPT Version :9

Sequence 1:NP_001246198.1 Gene:CG14762 / 35768 FlyBaseID:FBgn0033250 Length:498 Species:Drosophila melanogaster
Sequence 2:NP_852607.3 Gene:LRRC70 / 100130733 HGNCID:35155 Length:622 Species:Homo sapiens


Alignment Length:485 Identity:131/485 - (27%)
Similarity:210/485 - (43%) Gaps:88/485 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MAGIQLQSGCT---MVVTVVLLLQVLVMDQVLGQGPPQTQVCPEQSEIAPCICTVKKNGLDILCE 62
            |.|:|....|.   :|||..|||  |:..::||    .:.||.        :||    |..|.|.
Human     1 MCGLQFSLPCLRLFLVVTCYLLL--LLHKEILG----CSSVCQ--------LCT----GRQINCR 47

  Fly    63 TTDLAHITKSMGTLKGKSPIIFYLKLRHNNLPKLQGFVFLALDIRHLTIHNSSLAAIEENALSSL 127
            ...|:.|.|                    |.|:...|::|.         .::::.|.|:.|:.|
Human    48 NLGLSSIPK--------------------NFPESTVFLYLT---------GNNISYINESELTGL 83

  Fly   128 GAGLTQLDVSLNQMKTVPSQALQHLFHLLILNLNHNKITVIHNNAFEGLETLEILTLYENKITQI 192
            .: |..|.:..:.:..|..:|...|.||..|.||:|.|..:....|:||..|..|.|..|:::.:
Human    84 HS-LVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFKGLLNLRNLYLQYNQVSFV 147

  Fly   193 DPEAFRGLEDHIKRLNLGGNDLTNIPQKALSILSTLKKLEIQENKIRTISEGDFEGLQSLDSLIL 257
            ....|..|.. ::.|||..|.||.:.......:..|:.|::..|.|..|||..|:.|::|..|.|
Human   148 PRGVFNDLVS-VQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNILRISESGFQHLENLACLYL 211

  Fly   258 AHNMITTVPANVFSHLTLLNSLELEGNKISVIDKDAFKGLEENLQYLRLGDNQIHTIPSEALRPL 322
            ..|.:|.||:|.|..|..|..|.|..|.|..|...||||| .||:||.|.:::|..:..:....:
Human   212 GSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFKGL-ANLEYLLLKNSRIRNVTRDGFSGI 275

  Fly   323 HRLRHLDLRNNNINVLAEDAFTGFGDSLTFLNLQKNDIKVLPSLLFENLN-SLETLNLQNNKLQR 386
            :.|:||.|.:|::..|..|.|: ...:|.:|.|.:|.|..:.:..|||:. ||:.|||..|.|..
Human   276 NNLKHLILSHNDLENLNSDTFS-LLKNLIYLKLDRNRIISIDNDTFENMGASLKILNLSFNNLTA 339

  Fly   387 IPQDIMEPVIDTLRIIDITDNPLNCSCELTWFPKLLEDLKNKDDEMSQKKKPLCHMSLDNREYFV 451
            :...:::| :.:|..:....||..|:|:|                            |..|::..
Human   340 LHPRVLKP-LSSLIHLQANSNPWECNCKL----------------------------LGLRDWLA 375

  Fly   452 QAMPTEKMHCAGLNVSPSPTSGGLMRILQV 481
            .:..|..::|.    :|....|..:|.:.:
Human   376 SSAITLNIYCQ----NPPSMRGRALRYINI 401

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG14762NP_001246198.1 leucine-rich repeat 85..105 CDD:275380 4/19 (21%)
LRR_RI 93..384 CDD:238064 92/291 (32%)
leucine-rich repeat 107..129 CDD:275380 4/21 (19%)
leucine-rich repeat 131..154 CDD:275380 5/22 (23%)
LRR_8 154..214 CDD:290566 20/59 (34%)
leucine-rich repeat 155..178 CDD:275380 9/22 (41%)
leucine-rich repeat 179..203 CDD:275380 6/23 (26%)
leucine-rich repeat 204..227 CDD:275380 6/22 (27%)
LRR_8 226..286 CDD:290566 23/59 (39%)
leucine-rich repeat 228..251 CDD:275380 9/22 (41%)
leucine-rich repeat 252..275 CDD:275380 10/22 (45%)
LRR_8 276..335 CDD:290566 22/58 (38%)
leucine-rich repeat 276..300 CDD:275380 11/23 (48%)
leucine-rich repeat 301..324 CDD:275380 5/22 (23%)
leucine-rich repeat 325..349 CDD:275380 8/23 (35%)
LRR_8 349..409 CDD:290566 18/60 (30%)
leucine-rich repeat 350..373 CDD:275380 8/23 (35%)
LRRC70NP_852607.3 LRRNT 31..62 CDD:214470 13/66 (20%)
LRR 1 61..82 5/29 (17%)
leucine-rich repeat 65..85 CDD:275380 5/28 (18%)
LRR_8 85..144 CDD:290566 19/59 (32%)
LRR 2 85..106 4/21 (19%)
leucine-rich repeat 86..109 CDD:275380 5/22 (23%)
LRR 3 109..130 8/20 (40%)
leucine-rich repeat 110..133 CDD:275380 9/22 (41%)
LRR_8 133..192 CDD:290566 15/59 (25%)
LRR 4 133..154 5/20 (25%)
leucine-rich repeat 134..157 CDD:275380 6/22 (27%)
LRR 5 157..178 6/21 (29%)
leucine-rich repeat 158..181 CDD:275380 6/22 (27%)
LRR_RI <159..340 CDD:238064 65/182 (36%)
LRR 6 181..202 8/20 (40%)
LRR_8 182..240 CDD:290566 23/57 (40%)
leucine-rich repeat 182..205 CDD:275380 9/22 (41%)
LRR 7 205..226 9/20 (45%)
leucine-rich repeat 206..229 CDD:275380 10/22 (45%)
LRR_8 228..288 CDD:290566 22/60 (37%)
LRR 8 229..250 8/20 (40%)
leucine-rich repeat 230..253 CDD:275380 11/23 (48%)
LRR 9 253..274 6/20 (30%)
leucine-rich repeat 254..277 CDD:275380 5/22 (23%)
LRR_8 277..337 CDD:290566 22/60 (37%)
LRR 10 277..298 8/21 (38%)
leucine-rich repeat 278..301 CDD:275380 8/23 (35%)
LRR 11 301..322 6/20 (30%)
leucine-rich repeat 302..326 CDD:275380 8/23 (35%)
LRR 12 326..347 7/20 (35%)
leucine-rich repeat 327..348 CDD:275380 7/21 (33%)
LRRCT 359..398 CDD:214507 11/70 (16%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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