Protein Alignment CG14762 and LRRC70

DIOPT Version :10

• Sequence 1: NP_001246198.1
• Gene: CG14762 / 35768
• FlyBaseID: FBgn0033250
• Length: 498
• Species: Drosophila melanogaster
• Sequence 2: NP_852607.3
• Gene: LRRC70 / 100130733
• HGNCID: 35155
• Length: 622
• Species: Homo sapiens
• Alignment Length: 485
• Identity: 131/485 - (27%)
• Similarity: 210/485 - (43%)
• Gaps: 88/485 - (18%)

  Fly     1 MAGIQLQSGCT---MVVTVVLLLQVLVMDQVLGQGPPQTQVCPEQSEIAPCICTVKKNGLDILCE 62
            |.|:|....|.   :|||..|||  |:..::||    .:.||.        :||    |..|.|.
Human     1 MCGLQFSLPCLRLFLVVTCYLLL--LLHKEILG----CSSVCQ--------LCT----GRQINCR 47

  Fly    63 TTDLAHITKSMGTLKGKSPIIFYLKLRHNNLPKLQGFVFLALDIRHLTIHNSSLAAIEENALSSL 127
            ...|:.|.|                    |.|:...|::|.         .::::.|.|:.|:.|
Human    48 NLGLSSIPK--------------------NFPESTVFLYLT---------GNNISYINESELTGL 83

  Fly   128 GAGLTQLDVSLNQMKTVPSQALQHLFHLLILNLNHNKITVIHNNAFEGLETLEILTLYENKITQI 192
            .: |..|.:..:.:..|..:|...|.||..|.||:|.|..:....|:||..|..|.|..|:::.:
Human    84 HS-LVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFKGLLNLRNLYLQYNQVSFV 147

  Fly   193 DPEAFRGLEDHIKRLNLGGNDLTNIPQKALSILSTLKKLEIQENKIRTISEGDFEGLQSLDSLIL 257
            ....|..|.. ::.|||..|.||.:.......:..|:.|::..|.|..|||..|:.|::|..|.|
Human   148 PRGVFNDLVS-VQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNILRISESGFQHLENLACLYL 211

  Fly   258 AHNMITTVPANVFSHLTLLNSLELEGNKISVIDKDAFKGLEENLQYLRLGDNQIHTIPSEALRPL 322
            ..|.:|.||:|.|..|..|..|.|..|.|..|...||||| .||:||.|.:::|..:..:....:
Human   212 GSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFKGL-ANLEYLLLKNSRIRNVTRDGFSGI 275

  Fly   323 HRLRHLDLRNNNINVLAEDAFTGFGDSLTFLNLQKNDIKVLPSLLFENLN-SLETLNLQNNKLQR 386
            :.|:||.|.:|::..|..|.|: ...:|.:|.|.:|.|..:.:..|||:. ||:.|||..|.|..
Human   276 NNLKHLILSHNDLENLNSDTFS-LLKNLIYLKLDRNRIISIDNDTFENMGASLKILNLSFNNLTA 339

  Fly   387 IPQDIMEPVIDTLRIIDITDNPLNCSCELTWFPKLLEDLKNKDDEMSQKKKPLCHMSLDNREYFV 451
            :...:::| :.:|..:....||..|:|:|                            |..|::..
Human   340 LHPRVLKP-LSSLIHLQANSNPWECNCKL----------------------------LGLRDWLA 375

  Fly   452 QAMPTEKMHCAGLNVSPSPTSGGLMRILQV 481
            .:..|..::|.    :|....|..:|.:.:
Human   376 SSAITLNIYCQ----NPPSMRGRALRYINI 401

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14762	NP_001246198.1	leucine-rich repeat	85..105	CDD:275380	4/19 (21%)
		leucine-rich repeat	107..129	CDD:275380	4/21 (19%)
		LRR	<131..410	CDD:443914	90/279 (32%)
		leucine-rich repeat	131..154	CDD:275380	5/22 (23%)
		leucine-rich repeat	155..178	CDD:275380	9/22 (41%)
		leucine-rich repeat	179..203	CDD:275380	6/23 (26%)
		leucine-rich repeat	204..227	CDD:275380	6/22 (27%)
		leucine-rich repeat	228..251	CDD:275380	9/22 (41%)
		leucine-rich repeat	252..275	CDD:275380	10/22 (45%)
		leucine-rich repeat	276..300	CDD:275380	11/23 (48%)
		leucine-rich repeat	301..324	CDD:275380	5/22 (23%)
		leucine-rich repeat	325..349	CDD:275380	8/23 (35%)
		leucine-rich repeat	350..373	CDD:275380	8/23 (35%)
LRRC70	NP_852607.3	LRRNT	31..59	CDD:396168	12/63 (19%)
		LRR	49..>383	CDD:443914	107/395 (27%)
		LRR 1	61..82		5/29 (17%)
		leucine-rich repeat	65..85	CDD:275380	5/28 (18%)
		LRR 2	85..106		4/21 (19%)
		leucine-rich repeat	86..109	CDD:275380	5/22 (23%)
		LRR 3	109..130		8/20 (40%)
		leucine-rich repeat	110..133	CDD:275380	9/22 (41%)
		LRR 4	133..154		5/20 (25%)
		leucine-rich repeat	134..157	CDD:275380	6/22 (27%)
		LRR 5	157..178		6/21 (29%)
		leucine-rich repeat	158..181	CDD:275380	6/22 (27%)
		LRR 6	181..202		8/20 (40%)
		leucine-rich repeat	182..205	CDD:275380	9/22 (41%)
		LRR 7	205..226		9/20 (45%)
		leucine-rich repeat	206..229	CDD:275380	10/22 (45%)
		LRR 8	229..250		8/20 (40%)
		leucine-rich repeat	230..253	CDD:275380	11/23 (48%)
		LRR 9	253..274		6/20 (30%)
		leucine-rich repeat	254..277	CDD:275380	5/22 (23%)
		LRR 10	277..298		8/21 (38%)
		leucine-rich repeat	278..301	CDD:275380	8/23 (35%)
		LRR 11	301..322		6/20 (30%)
		leucine-rich repeat	302..326	CDD:275380	8/23 (35%)
		LRR 12	326..347		7/20 (35%)
		leucine-rich repeat	327..348	CDD:275380	7/21 (33%)