DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14762 and lrrn1-like

DIOPT Version :9

Sequence 1:	NP_001246198.1	Gene:	CG14762 / 35768	FlyBaseID:	FBgn0033250	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	NP_001106456.1	Gene:	lrrn1-like / 100127637	XenbaseID:	XB-GENE-492890	Length:	738	Species:	Xenopus tropicalis

Alignment Length:	475	Identity:	126/475 - (26%)
Similarity:	201/475 - (42%)	Gaps:	91/475 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LQVLVMDQV----LGQGPPQTQVCPEQSEIAPCIC---------TVKKNGLDILCETTDLAHITK 71
            |.|:|:..|    ||       |||.|     |:|         :|......:.|....|.||.:
Frog    22 LFVIVLHSVFFSTLG-------VCPPQ-----CVCETRPWFTPQSVYHEAKTVDCNDLLLTHIPE 74

  Fly    72 SMGTLKGKSPIIFYLKLRHNNLPKLQGFVFLALDIRHLTIHNSSLAAIEENALSSLGAGLTQLDV 136
            ::.|      .|..|.|:.|.:..|...:....::..|.:..:...:|::..:|:|...:| |.:
Frog    75 NLST------DIQVLLLQSNKISHLTWELQELSNLTELDLSQNHFQSIDDLGVSNLSQLIT-LYL 132

  Fly   137 SLNQMKTVPSQALQHLFHLLILNLNHNKITVIHNNAFEGLETLEILTLYENKITQIDPEAFRGLE 201
            ..||::.:|..:|:.|..|..|.:|||:|:.|...||.||..|..|.|..|::..|||..|..|
Frog   133 EENQLRELPDYSLKDLGSLEELYINHNQISYIGPRAFSGLGRLLRLHLNANRLEIIDPRWFEDL- 196

  Fly   202 DHIKRLNLGGNDLTNIPQKALSILSTLKKLEIQENKIRTISEGDFEGLQSLDSLILAHNMITTVP 266
            .:::.|.:|.|.:|.:.......|..|..|.:...::..|.|..|:||..|:||....|.:|.||
Frog   197 PNLEILMVGENPVTALQSLNFQPLGRLHSLVLAGMELEHIPENAFQGLDYLESLSFFDNRLTEVP 261

  Fly   267 ANVFSHLTLLNSLELEGNKISVIDKDAFKGLEENLQYLRLGD-NQIHTIPSEALRPLHRLRHLDL 330
            .....:|.||..|:|..|.|..|....|.|: |:|:.|.|.. .::..:.:||.:.|..|..|::
Frog   262 KEALKNLKLLKFLDLNKNPIPEIRGGDFTGM-EHLEELSLNSMEELERVEAEAFQDLPELIKLEM 325

  Fly   331 RNNNINVLAEDAFTGFGDSLTFLNLQKNDIKVLPSLLFENLNSLETLNLQNNKLQRIPQDIMEPV 395
            .||              ..|::|:         |.....||.:|:||.|.||:|..:|..|.:.:
Frog   326 CNN--------------PRLSYLD---------PEAFSSNLGALKTLLLNNNRLAMVPLKIFQAL 367

  Fly   396 IDTLRIIDITDNPLNCSCELTWFPKLLEDLKNKDDEMSQKKKPLCHMSLDNREYFVQAMPTEKMH 460
            ...|. |.:..||:.|.|:..|  |.|..|:                       .::|..|
Frog   368 PGLLE-ISLYSNPIRCDCQNCW--KGLSKLR-----------------------LIEAQAT---- 402

  Fly   461 CAGLNVSPSPTSGGLMRILQ 480
               |.::|...||.|.:.:|
Frog   403 ---LCINPPLVSGHLFQEIQ 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14762	NP_001246198.1	leucine-rich repeat	85..105	CDD:275380	4/19 (21%)
		LRR_RI	93..384	CDD:238064	83/291 (29%)
		leucine-rich repeat	107..129	CDD:275380	4/21 (19%)
		leucine-rich repeat	131..154	CDD:275380	7/22 (32%)
		LRR_8	154..214	CDD:290566	23/59 (39%)
		leucine-rich repeat	155..178	CDD:275380	11/22 (50%)
		leucine-rich repeat	179..203	CDD:275380	9/23 (39%)
		leucine-rich repeat	204..227	CDD:275380	5/22 (23%)
		LRR_8	226..286	CDD:290566	20/59 (34%)
		leucine-rich repeat	228..251	CDD:275380	7/22 (32%)
		leucine-rich repeat	252..275	CDD:275380	8/22 (36%)
		LRR_8	276..335	CDD:290566	19/59 (32%)
		leucine-rich repeat	276..300	CDD:275380	8/23 (35%)
		leucine-rich repeat	301..324	CDD:275380	6/23 (26%)
		leucine-rich repeat	325..349	CDD:275380	4/23 (17%)
		LRR_8	349..409	CDD:290566	17/59 (29%)
		leucine-rich repeat	350..373	CDD:275380	5/22 (23%)
lrrn1-like	NP_001106456.1	NEL	<52..>262	CDD:330839	60/217 (28%)
		leucine-rich repeat	60..79	CDD:275380	5/24 (21%)
		leucine-rich repeat	80..102	CDD:275380	5/21 (24%)
		LRR_8	101..161	CDD:316378	16/60 (27%)
		leucine-rich repeat	103..126	CDD:275380	4/22 (18%)
		leucine-rich repeat	127..150	CDD:275380	7/23 (30%)
		leucine-rich repeat	151..174	CDD:275380	11/22 (50%)
		leucine-rich repeat	175..198	CDD:275380	9/23 (39%)
		leucine-rich repeat	199..222	CDD:275380	5/22 (23%)
		leucine-rich repeat	223..246	CDD:275380	7/22 (32%)
		leucine-rich repeat	247..294	CDD:275380	17/47 (36%)
		LRR_8	294..356	CDD:316378	21/84 (25%)
		leucine-rich repeat	295..319	CDD:275380	6/23 (26%)
		leucine-rich repeat	320..345	CDD:275380	9/47 (19%)
		leucine-rich repeat	346..367	CDD:275380	9/20 (45%)
		PCC	351..>412	CDD:188093	20/93 (22%)
		leucine-rich repeat	370..382	CDD:275378	4/12 (33%)
		Ig	448..515	CDD:319273
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X351
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910