DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14762 and slitrk3b

DIOPT Version :9

Sequence 1:	NP_001246198.1	Gene:	CG14762 / 35768	FlyBaseID:	FBgn0033250	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	XP_001346135.2	Gene:	slitrk3b / 100007758	ZFINID:	ZDB-GENE-070912-352	Length:	882	Species:	Danio rerio

Alignment Length:	672	Identity:	154/672 - (22%)
Similarity:	230/672 - (34%)	Gaps:	276/672 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 PCICTVKKNGLDILCETTDLAHITK-SMGTLKGKSPIIFYLKLRHNNLPKLQGFVFLALDIRHLT 110
            ||.|.||:....:.|::....:|:: |...|:.     |.|.|:.|:|.||....||     ||
Zfish    43 PCYCEVKEGLFHVHCDSKGFTNISQVSQSWLRP-----FKLYLQKNSLRKLYFNSFL-----HL- 96

  Fly   111 IHNSSLAAIEENALSSLGAGLTQLDVSLNQMKTVPSQALQHLFHLLILNLNHNKITVIHNNAFEG 175
             :|:....:..|||..:..|                 |...|..|..|.|:.||:.|..|:.|.|
Zfish    97 -NNAVAINLGNNALQDIHVG-----------------AFNGLGSLKRLYLHENKLEVFRNDTFLG 143

  Fly   176 LETLEILTLYENKITQIDPEAFRGLED----------------------HIKRLNLGGNDLTNIP 218
            ||:||.|....|.|.:||..|||.|..                      .:..|:|.||.|..:|
Zfish   144 LESLEYLQADYNVIKRIDSGAFRNLHKLRVLILNDNLIPVLPAFLFRSVSLTHLDLRGNRLKTLP 208

  Fly   219 QKAL--SILSTLKKLEIQEN--------------------------------------KIRTI-- 241
            .|.:  .|..:|.:::::||                                      .:|.|
Zfish   209 YKGILEYIGRSLMEIQLEENPWNCICDIIQLQAWLERIPYTAVVGEITCEYPFHLHGKDLREIKR 273

  Fly   242 -------SEGDFEGLQSL--------------DSLILAHNMITT--------------------- 264
                   :|.:.|.:..:              .|.|::.|..|.
Zfish   274 SELCPLLNEAEIESILGVLHLPFYTGRARPTKPSSIVSSNQNTVSSVEQRERPPKPTKRPRPSKT 338

  Fly   265 --VPANVFSH-------------------------------LTL-----------------LNS- 278
              .|.:||.:                               ||:                 ||:
Zfish   339 PPTPRSVFPNQPPVAGYQTRPPIPIICPIGCTCNLHINDLGLTVNCKENGFRNISELMPRPLNAK 403

  Fly   279 -LELEGNKISVIDKDAFKGLEENLQYLRLGDNQIHTIPSEALRPLHRLRHLDLRNNNINVLAEDA 342
             |.|.||.|..|.|..|... .:|..|.||:|||..:...|...|..||.|.|..|||..|..|.
Zfish   404 KLYLSGNLIQRIYKSDFWNF-SSLDLLHLGNNQIFYVQEGAFVNLPNLRSLYLNGNNIVKLTIDM 467

  Fly   343 FTGFGDSLTFLNLQKNDIK--------VLPS--LLFENLNSLET-------------LNLQNNKL 384
            |.|. .||.:|..:.|:|:        ::||  |:|.|.|.|.|             |||:||..
Zfish   468 FHGL-HSLEYLYFEYNEIREIQPAAFSLMPSLQLVFLNNNLLRTLPMGAFEGTSLTRLNLRNNYF 531

  Fly   385 QRIPQDIMEPVIDTLRI---IDITDNPLNCSCEL----TWF----------------PKLL--ED 424
            ..:|   :..|::.|:.   ||:..||.:|||::    .|.                |:|:  :|
Zfish   532 HCLP---VSGVLEHLQAVVQIDLNQNPWDCSCDIIPLKEWLDTLSLVVIVGEVACKTPELVSGKD 593

  Fly   425 LKNKDDEMSQKKKPLC----HMSLDNREYFVQAMPTEKMHCAGL-----NVSPSPTSGGL-MRIL 479
            |:..:.|:      :|    ..||.         |.|.  .:||     .|.|.|..|.: :.:|
Zfish   594 LRTLNSEV------ICPELRQSSLS---------PAES--DSGLITTYPEVGPHPPKGAIPLSVL 641

  Fly   480 QVNIL--------AQIAVCSVA 493
            .:::|        |..|:|:.|
Zfish   642 ILSLLVLFVSAFFAAAALCAYA 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14762	NP_001246198.1	leucine-rich repeat	85..105	CDD:275380	8/19 (42%)
		LRR_RI	93..384	CDD:238064	108/471 (23%)
		leucine-rich repeat	107..129	CDD:275380	6/21 (29%)
		leucine-rich repeat	131..154	CDD:275380	2/22 (9%)
		LRR_8	154..214	CDD:290566	26/81 (32%)
		leucine-rich repeat	155..178	CDD:275380	10/22 (45%)
		leucine-rich repeat	179..203	CDD:275380	11/45 (24%)
		leucine-rich repeat	204..227	CDD:275380	8/24 (33%)
		LRR_8	226..286	CDD:290566	22/193 (11%)
		leucine-rich repeat	228..251	CDD:275380	7/69 (10%)
		leucine-rich repeat	252..275	CDD:275380	8/90 (9%)
		LRR_8	276..335	CDD:290566	24/60 (40%)
		leucine-rich repeat	276..300	CDD:275380	10/25 (40%)
		leucine-rich repeat	301..324	CDD:275380	9/22 (41%)
		leucine-rich repeat	325..349	CDD:275380	11/23 (48%)
		LRR_8	349..409	CDD:290566	24/85 (28%)
		leucine-rich repeat	350..373	CDD:275380	9/32 (28%)
slitrk3b	XP_001346135.2	leucine-rich repeat	52..72	CDD:275380	3/19 (16%)
		leucine-rich repeat	73..98	CDD:275380	12/36 (33%)
		LRR_8	77..133	CDD:290566	21/79 (27%)
		leucine-rich repeat	99..122	CDD:275380	6/39 (15%)
		LRR_RI	<102..206	CDD:238064	33/120 (28%)
		LRR_8	122..181	CDD:290566	22/58 (38%)
		leucine-rich repeat	123..146	CDD:275380	10/22 (45%)
		leucine-rich repeat	147..170	CDD:275380	11/22 (50%)
		leucine-rich repeat	171..193	CDD:275380	0/21 (0%)
		TPKR_C2	228..278	CDD:301599	3/49 (6%)
		leucine-rich repeat	381..401	CDD:275380	1/19 (5%)
		LRR_RI	385..>555	CDD:238064	53/174 (30%)
		LRR_8	401..460	CDD:290566	23/59 (39%)
		leucine-rich repeat	402..425	CDD:275380	8/23 (35%)
		leucine-rich repeat	426..449	CDD:275380	9/22 (41%)
		LRR_8	448..508	CDD:290566	22/60 (37%)
		LRR_4	448..489	CDD:289563	16/41 (39%)
		leucine-rich repeat	450..473	CDD:275380	11/23 (48%)
		leucine-rich repeat	474..497	CDD:275380	4/22 (18%)
		LRR_8	496..555	CDD:290566	18/61 (30%)
		leucine-rich repeat	498..520	CDD:275380	6/21 (29%)
		leucine-rich repeat	521..545	CDD:275380	8/26 (31%)
		LRRCT	554..604	CDD:214507	11/55 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H124649
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000