DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Odc2 and SPE1

DIOPT Version :9

Sequence 1:	NP_477053.2	Gene:	Odc2 / 35767	FlyBaseID:	FBgn0013308	Length:	393	Species:	Drosophila melanogaster
Sequence 2:	NP_012737.1	Gene:	SPE1 / 853651	SGDID:	S000001667	Length:	466	Species:	Saccharomyces cerevisiae

Alignment Length:	438	Identity:	154/438 - (35%)
Similarity:	225/438 - (51%)	Gaps:	77/438 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 QYYDEELNIRKVI----EQADLEHLD---------QALN--------------------ICDLSS 40
            |||.:...:..::    ...|||.|.         |||.                    ||||..
Yeast    30 QYYKDGETLHNLLLELKNNQDLELLPHEQAHPKIFQALKARIGRINNETCDPGEENSFFICDLGE 94

  Fly    41 LERKLRLWHKLMPRIEPHYAVKCNDDPVVVKFLADLGTGFDCASKNELKLVLGLGVSPERIIFAH 105
            ::|....|.|.:|||:|.||||||.|..|:..||:||..||||||.|:..||.:.:||:||::|:
Yeast    95 VKRLFNNWVKELPRIKPFYAVKCNPDTKVLSLLAELGVNFDCASKVEIDRVLSMNISPDRIVYAN 159

  Fly   106 PCRPASHLRYAKEQQVVNGTVDNEYEIYKLRKHYPDSNLIVRFKSEAKKALCPLGDKYGCDAEAD 170
            ||:.||.:|||..:.|:..|.||..|::|::|.:|:|.|::|..::...|.|.|..||||:.| :
Yeast   160 PCKVASFIRYAASKNVMKSTFDNVEELHKIKKFHPESQLLLRIATDDSTAQCRLSTKYGCEME-N 223

  Fly   171 AAALMLLAKALGLKVTGTSFHVGSGCSEVEAYDRAIEKAENIF-KVGEMIG-HKMELLDVGGGFP 233
            ...|:...|.|||.:.|.|||||||.|:..:..:|:..|..:| |.....| ..:::|||||||
Yeast   224 VDVLLKAIKELGLNLAGVSFHVGSGASDFTSLYKAVRDARTVFDKAANEYGLPPLKILDVGGGF- 287

  Fly   234 GIDDEMFEEIAQSVNTSVELRFP-DKRIRIISEPGRFFVEAAYTLICKVHAKREVRSKDGKLDTM 297
              ..|.|:|....:..::|..|| ...:.||:||||:||..|:||...|.|||::...:.
Yeast   288 --QFESFKESTAVLRLALEEFFPVGCGVDIIAEPGRYFVATAFTLASHVIAKRKLSENEA----- 345

  Fly   298 MYYLNDGIFGAFAGMFYYPEEVAP-------ELYLDEAESLPKL-------------KSVIWGPS 342
            |.|.|||::|....:.:..:|..|       |.:.|:.||...:             |..||||:
Yeast   346 MIYTNDGVYGNMNCILFDHQEPHPRTLYHNLEFHYDDFESTTAVLDSINKTRSEYPYKVSIWGPT 410

  Fly   343 CDAMDKIS-------DLLLPNLNPGDLLGFRNMGAYTMPIASPFNGFD 383
            ||.:|.|:       |:::     ||...|..:||||...|:.||||:
Yeast   411 CDGLDCIAKEYYMKHDVIV-----GDWFYFPALGAYTSSAATQFNGFE 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Odc2	NP_477053.2	LysA	21..385	CDD:223098	151/426 (35%)
Odc2	NP_477053.2	PLPDE_III_ODC	30..390	CDD:143482	147/413 (36%)
SPE1	NP_012737.1	PLPDE_III_ODC	84..460	CDD:143482	144/384 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344107
Domainoid	1	1.000	184	1.000	Domainoid score	I684
eggNOG	1	0.900	-	-		E1_COG0019
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1906
Inparanoid	1	1.050	260	1.000	Inparanoid score	I628
Isobase	1	0.950	-	0	Normalized mean entropy	S945
OMA	1	1.010	-	-		QHG62480
OrthoFinder	1	1.000	-	-		FOG0000435
OrthoInspector	1	1.000	-	-		otm46600
orthoMCL	1	0.900	-	-		OOG6_100277
Panther	1	1.100	-	-	O	PTHR11482
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X335
TreeFam	1	0.960	-	-
	15	14.710