DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Odc1 and SPE1

DIOPT Version :9

Sequence 1:	NP_477052.2	Gene:	Odc1 / 35766	FlyBaseID:	FBgn0013307	Length:	394	Species:	Drosophila melanogaster
Sequence 2:	NP_012737.1	Gene:	SPE1 / 853651	SGDID:	S000001667	Length:	466	Species:	Saccharomyces cerevisiae

Alignment Length:	414	Identity:	167/414 - (40%)
Similarity:	231/414 - (55%)	Gaps:	52/414 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ATPEIQFYERELNIRRVIEE-CDLQRLDQALNICDLSSVERKLRLWQKLLPRIKPFYAVKCNDDP 67
            |.|:| |...:..|.|:..| ||... :.:..||||..|:|....|.|.|||||||||||||.|.
Yeast    59 AHPKI-FQALKARIGRINNETCDPGE-ENSFFICDLGEVKRLFNNWVKELPRIKPFYAVKCNPDT 121

  Fly    68 MVVRLLAQLGAGFDCASKNEVKLVLGFDVSPERIIFANPCRPVSHLEYAKEHQVSNGTVDNEFEV 132
            .|:.|||:||..||||||.|:..||..::||:||::||||:..|.:.||....|...|.||..|:
Yeast   122 KVLSLLAELGVNFDCASKVEIDRVLSMNISPDRIVYANPCKVASFIRYAASKNVMKSTFDNVEEL 186

  Fly   133 YKLHTHYPNSNLIVRFKSEAKEAQCPLGDKFGCDAD-VDAAALMLLAKSLELKVTGTSFHVGSGC 196
            :|:...:|.|.|::|..::...|||.|..|:||:.: ||  .|:...|.|.|.:.|.|||||||.
Yeast   187 HKIKKFHPESQLLLRIATDDSTAQCRLSTKYGCEMENVD--VLLKAIKELGLNLAGVSFHVGSGA 249

  Fly   197 SELQAYDRAIKKAKNLF-----KFGALLGYDMDFLDIGGGFPGSDDVKFEKIAES---VNTSVQR 253
            |:..:..:|::.|:.:|     ::|.   ..:..||:||||      :||...||   :..:::.
Yeast   250 SDFTSLYKAVRDARTVFDKAANEYGL---PPLKILDVGGGF------QFESFKESTAVLRLALEE 305

  Fly   254 HFP-DERVHIIAEPGRFFVAAACTLVCKIHAKREI-RNEAGKLDTVMYYLNDGVYGSFNCILYDH 316
            .|| ...|.|||||||:|||.|.||...:.|||:: .|||      |.|.||||||:.||||:||
Yeast   306 FFPVGCGVDIIAEPGRYFVATAFTLASHVIAKRKLSENEA------MIYTNDGVYGNMNCILFDH 364

  Fly   317 QVV--------IAEHYLDNAESLPHLKSL------------IWGPSCDALDKISEDLHLP-NLNR 360
            |..        :..||.|...:...|.|:            ||||:||.||.|:::.::. ::..
Yeast   365 QEPHPRTLYHNLEFHYDDFESTTAVLDSINKTRSEYPYKVSIWGPTCDGLDCIAKEYYMKHDVIV 429

  Fly   361 GDLLGFRNMGAYTMPIASAFNGFE 384
            ||...|..:||||...|:.|||||
Yeast   430 GDWFYFPALGAYTSSAATQFNGFE 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Odc1	NP_477052.2	LysA	16..391	CDD:223098	163/402 (41%)
Odc1	NP_477052.2	PLPDE_III_ODC	30..391	CDD:143482	158/387 (41%)
SPE1	NP_012737.1	PLPDE_III_ODC	84..460	CDD:143482	158/387 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344106
Domainoid	1	1.000	184	1.000	Domainoid score	I684
eggNOG	1	0.900	-	-		E1_COG0019
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1906
Inparanoid	1	1.050	260	1.000	Inparanoid score	I628
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62480
OrthoFinder	1	1.000	-	-		FOG0000435
OrthoInspector	1	1.000	-	-		otm46600
orthoMCL	1	0.900	-	-		OOG6_100277
Panther	1	1.100	-	-	LDO	PTHR11482
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R297
SonicParanoid	1	1.000	-	-		X335
TreeFam	1	0.960	-	-
	15	14.790