Protein Alignment Hey and BHLHE40

DIOPT Version :10

• Sequence 1: NP_523657.1
• Gene: Hey / 35764
• FlyBaseID: FBgn0027788
• Length: 425
• Species: Drosophila melanogaster
• Sequence 2: NP_003661.1
• Gene: BHLHE40 / 8553
• HGNCID: 1046
• Length: 412
• Species: Homo sapiens
• Alignment Length: 460
• Identity: 103/460 - (22%)
• Similarity: 157/460 - (34%)
• Gaps: 135/460 - (29%)

  Fly    39 PPPQSHHSAHSNHSHGHSQG----HSHGIGSLKRTLSESDCDDLYSEESSKEQISPSEPGSCQLM 99
            |||.....| ....||...|    |.:.:...:|.:..|        |.|||
Human     9 PPPACLPKA-PGLEHGDLPGMYPAHMYQVYKSRRGIKRS--------EDSKE------------- 51

  Fly   100 SRKKRRGVIEKKRRDRINSSLTELKRLVPSAYEKQGSAKLEKAEILQLTVEHLKSL-------QS 157
            :.|....:||||||||||..:.:||.|:|...:......||||.:|:||::|:|:|       |.
Human    52 TYKLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHVKALTNLIDQQQQ 116

  Fly   158 KTL--------DSLSYDPQRVAMDYHIIGFRECAAEVARYLVTIEGMDIQDPLRLRLMSHLQYFV 214
            |.:        ..||........:....||:.||.||.:||...|  :.:|....:|::||...|
Human   117 KIIALQSGLQAGELSGRNVETGQEMFCSGFQTCAREVLQYLAKHE--NTRDLKSSQLVTHLHRVV 179

  Fly   215 QQRELSAKSCASPGGWSPAAPSSSGYQPNCAAAPYQSYAAPANPGAYVSSYPTLSASPSQQAQQL 279
            .:        ...||.|                     ..|::|...|..:....:||::.::..
Human   180 SE--------LLQGGTS---------------------RKPSDPAPKVMDFKEKPSSPAKGSEGP 215

  Fly   280 GGR--TSVSRTSGSAVTESLPSHDLHSDS----SSQQQQQQQQQQQQQQQHQ------------Q 326
            |..  ..:.||...:..|...| |..:||    .|::...:.:|...:..|.            :
Human   216 GKNCVPVIQRTFAHSSGEQSGS-DTDTDSGYGGESEKGDLRSEQPCFKSDHGRRFTMGERIGAIK 279

  Fly   327 QQHQQQQQRTQTTPQPTQQQHYT------------HDHSAVHS---------------------- 357
            |:.::...:.........:.|:|            |.|.....
Human   280 QESEEPPTKKNRMQLSDDEGHFTSSDLISSPFLGPHPHQPPFCLPFYLIPPSATAYLPMLEKCWY 344

  Fly   358 EQQVPTYIELTNSNRPAAIGS----DSLSYS-AAPQYPVSGLPGQDYNNSSVLQYATPNGAKPYR 417
            ...||......|:: .||:.|    |.:|.. ..||...|.||.....:||||..|    .||..
Human   345 PTSVPVLYPGLNAS-AAALSSFMNPDKISAPLLMPQRLPSPLPAHPSVDSSVLLQA----LKPIP 404

  Fly   418 PWGAE 422
            |...|
Human   405 PLNLE 409

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hey	NP_523657.1	bHLH_SF	95..163	CDD:469605	27/82 (33%)
		ORANGE	172..218	CDD:128787	14/45 (31%)
BHLHE40	NP_003661.1	Essential for interaction with BMAL1, E-box binding and repressor activity against the CLOCK-BMAL1 heterodimer	1..139		43/151 (28%)
		bHLH-O_DEC1	40..129	CDD:381592	33/109 (30%)
		Necessary for interaction with RXRA and repressor activity against RXRA. /evidence=ECO:0000269|PubMed:19786558	75..79		2/3 (67%)
		ORANGE	140..184	CDD:128787	14/53 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	182..303		21/142 (15%)