DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Hey and BHLHE40

DIOPT Version :9

Sequence 1:NP_523657.1 Gene:Hey / 35764 FlyBaseID:FBgn0027788 Length:425 Species:Drosophila melanogaster
Sequence 2:NP_003661.1 Gene:BHLHE40 / 8553 HGNCID:1046 Length:412 Species:Homo sapiens


Alignment Length:460 Identity:103/460 - (22%)
Similarity:157/460 - (34%) Gaps:135/460 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    39 PPPQSHHSAHSNHSHGHSQG----HSHGIGSLKRTLSESDCDDLYSEESSKEQISPSEPGSCQLM 99
            |||.....| ....||...|    |.:.:...:|.:..|        |.|||             
Human     9 PPPACLPKA-PGLEHGDLPGMYPAHMYQVYKSRRGIKRS--------EDSKE------------- 51

  Fly   100 SRKKRRGVIEKKRRDRINSSLTELKRLVPSAYEKQGSAKLEKAEILQLTVEHLKSL-------QS 157
            :.|....:||||||||||..:.:||.|:|...:......||||.:|:||::|:|:|       |.
Human    52 TYKLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHVKALTNLIDQQQQ 116

  Fly   158 KTL--------DSLSYDPQRVAMDYHIIGFRECAAEVARYLVTIEGMDIQDPLRLRLMSHLQYFV 214
            |.:        ..||........:....||:.||.||.:||...|  :.:|....:|::||...|
Human   117 KIIALQSGLQAGELSGRNVETGQEMFCSGFQTCAREVLQYLAKHE--NTRDLKSSQLVTHLHRVV 179

  Fly   215 QQRELSAKSCASPGGWSPAAPSSSGYQPNCAAAPYQSYAAPANPGAYVSSYPTLSASPSQQAQQL 279
            .:        ...||.|                     ..|::|...|..:....:||::.::..
Human   180 SE--------LLQGGTS---------------------RKPSDPAPKVMDFKEKPSSPAKGSEGP 215

  Fly   280 GGR--TSVSRTSGSAVTESLPSHDLHSDS----SSQQQQQQQQQQQQQQQHQ------------Q 326
            |..  ..:.||...:..|...| |..:||    .|::...:.:|...:..|.            :
Human   216 GKNCVPVIQRTFAHSSGEQSGS-DTDTDSGYGGESEKGDLRSEQPCFKSDHGRRFTMGERIGAIK 279

  Fly   327 QQHQQQQQRTQTTPQPTQQQHYT------------HDHSAVHS---------------------- 357
            |:.::...:.........:.|:|            |.|.....                      
Human   280 QESEEPPTKKNRMQLSDDEGHFTSSDLISSPFLGPHPHQPPFCLPFYLIPPSATAYLPMLEKCWY 344

  Fly   358 EQQVPTYIELTNSNRPAAIGS----DSLSYS-AAPQYPVSGLPGQDYNNSSVLQYATPNGAKPYR 417
            ...||......|:: .||:.|    |.:|.. ..||...|.||.....:||||..|    .||..
Human   345 PTSVPVLYPGLNAS-AAALSSFMNPDKISAPLLMPQRLPSPLPAHPSVDSSVLLQA----LKPIP 404

  Fly   418 PWGAE 422
            |...|
Human   405 PLNLE 409

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HeyNP_523657.1 HLH 100..156 CDD:238036 25/62 (40%)
ORANGE 172..218 CDD:128787 14/45 (31%)
BHLHE40NP_003661.1 Essential for interaction with ARNTL/BMAL1, E-box binding and repressor activity against the CLOCK-ARNTL/BMAL1 heterodimer 1..139 43/151 (28%)
bHLH-O_DEC1 40..129 CDD:381592 33/109 (30%)
Necessary for interaction with RXRA and repressor activity against RXRA. /evidence=ECO:0000269|PubMed:19786558 75..79 2/3 (67%)
ORANGE 140..184 CDD:128787 14/53 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 182..303 21/142 (15%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4304
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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