DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hey and Hes7

DIOPT Version :9

Sequence 1:	NP_523657.1	Gene:	Hey / 35764	FlyBaseID:	FBgn0027788	Length:	425	Species:	Drosophila melanogaster
Sequence 2:	NP_149030.2	Gene:	Hes7 / 84653	MGIID:	2135679	Length:	225	Species:	Mus musculus

Alignment Length:	217	Identity:	60/217 - (27%)
Similarity:	91/217 - (41%)	Gaps:	34/217 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 KKRRGVIEKKRRDRINSSLTELKRLVPSAYEKQG--SAKLEKAEILQLTVEHLKSLQSKTLD--- 161
            |..:.::||:||||||.||.||:.|:......|.  :.||||||||:..|.:|:. :|:...
Mouse    14 KMLKPLVEKRRRDRINRSLEELRLLLLERTRDQNLRNPKLEKAEILEFAVGYLRE-RSRVEPPGV 77

  Fly   162 --SLSYDPQRVAMDYHIIGFRECAAEVARYLVTIEGMDIQDPLRLRLMSHLQYFVQQRELSAKSC 224
              |...|.:.:|..| :.|||||...:|.:     ..|.....|.:|.|.|..: ::.:......
Mouse    78 PRSPGQDAEALASCY-LSGFRECLLRLAAF-----AHDASPAARSQLFSALHGY-RRPKPPRPEA 135

  Fly   225 ASPGGWSPAAPSSSGYQPNCAAAPYQSYAAPANPGAYVSSYPTLSASPSQQAQQLGGRTSVS--- 286
            ..||..:|..|.... .|....|.:|.......|.:     |.|:.|||..:.:.|...:.:
Mouse   136 VDPGLPAPRPPLDPA-SPILGPALHQRPPVHQGPPS-----PRLAWSPSHCSSRAGDSGAPAPLT 194

  Fly   287 ----------RTSGSAVTESLP 298
                      |..|:....|||
Mouse   195 GLLPPPPPPYRQDGAPKAPSLP 216

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hey	NP_523657.1	HLH	100..156	CDD:238036	25/55 (45%)
Hey	NP_523657.1	ORANGE	172..218	CDD:128787	12/45 (27%)
Hes7	NP_149030.2	HLH	14..73	CDD:238036	26/59 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	124..225		19/100 (19%)
		WRPW motif	221..224
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810