DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hey and Bhlhe40

DIOPT Version :9

Sequence 1:	NP_523657.1	Gene:	Hey / 35764	FlyBaseID:	FBgn0027788	Length:	425	Species:	Drosophila melanogaster
Sequence 2:	NP_445780.2	Gene:	Bhlhe40 / 79431	RGDID:	68439	Length:	411	Species:	Rattus norvegicus

Alignment Length:	408	Identity:	95/408 - (23%)
Similarity:	133/408 - (32%)	Gaps:	136/408 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 GHSHGIGSLKRTLSESDCDDLYSEESSKEQISPSEPGSCQLMSRKKRRGVIEKKRRDRINSSLTE 122
            |..||      .||..|...:|....|:..|..||...   .:.|....:||||||||||..:.:
  Rat    19 GLEHG------DLSGMDFAHMYQVYKSRRGIKRSEDSK---ETYKLPHRLIEKKRRDRINECIAQ 74

  Fly   123 LKRLVPSAYEKQGSAKLEKAEILQLTVEHLKSL-------QSKTL--------DSLSYDPQRVAM 172
            ||.|:|...:......||||.:|:||::|:|:|       |.|.:        ..||........
  Rat    75 LKDLLPEHLKLTTLGHLEKAVVLELTLKHVKALTNLIDQQQQKIMALQSGLQAGDLSGRNIEAGQ 139

  Fly   173 DYHIIGFRECAAEVARYLVTIEGMDIQDPLRLRLMSHLQYFVQQRELSAKSCASPGGWSP----- 232
            :....||:.||.||.:||...|  :.:|....:|::||...|.:. |...:...|...:|
  Rat   140 EMFCSGFQTCAREVLQYLAKHE--NTRDLKSSQLVTHLHRVVSEL-LQGSASRKPLDSAPKPVDF 201

  Fly   233 ------AAPSSSGYQPNCAAAPYQSYAAPANPGAYVSSYPTLSASPSQQAQQLGGRTSVSRT-SG 290
                  .|..|.|...||.....:::|                  ||      ||..|.|.| :.
  Rat   202 KEKPSFLAKGSEGPGKNCVPVIQRTFA------------------PS------GGEQSGSDTDTD 242

  Fly   291 SAVTESLPSHDLHSDSSSQQQQQQQQQQQQQQQHQQQQHQQQQQRTQTTPQPTQQQHYTHDH--- 352
            |.....|...||.|                                       :|.::..||
  Rat   243 SGYGGELEKGDLRS---------------------------------------EQPYFKSDHGRR 268

  Fly   353 -------SAVHSEQQVPTYIELTNSNRPAA-------IGSDSLS---YSAAPQYPVSGLPGQDYN 400
                   |.:..|.:.|.    |..:|...       :|||.:.   ....|..|...||
  Rat   269 FTVGERVSTIKQESEEPP----TKKSRMQLSDEEGHFVGSDLMGSPFLGPHPHQPPFCLP----- 324

  Fly   401 NSSVLQYATPNGAKPYRP 418
                 .|..|..|..|.|
  Rat   325 -----FYLIPPSATAYLP 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hey	NP_523657.1	HLH	100..156	CDD:238036	25/62 (40%)
Hey	NP_523657.1	ORANGE	172..218	CDD:128787	14/45 (31%)
Bhlhe40	NP_445780.2	Essential for interaction with ARNTL/BMAL1, E-box binding and repressor activity against the CLOCK-ARNTL/BMAL1 heterodimer. /evidence=ECO:0000250	1..139		40/128 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21		1/1 (100%)
		bHLH-O_DEC1	40..129	CDD:381592	30/91 (33%)
		Necessary for interaction with RXRA and repressor activity against RXRA. /evidence=ECO:0000250	75..79		2/3 (67%)
		ORANGE	140..184	CDD:128787	14/46 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	186..293		28/173 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810