DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hey and Hes6

DIOPT Version :9

Sequence 1:	NP_523657.1	Gene:	Hey / 35764	FlyBaseID:	FBgn0027788	Length:	425	Species:	Drosophila melanogaster
Sequence 2:	NP_062352.1	Gene:	Hes6 / 55927	MGIID:	1859852	Length:	224	Species:	Mus musculus

Alignment Length:	214	Identity:	62/214 - (28%)
Similarity:	94/214 - (43%)	Gaps:	50/214 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 RKKRRGVIEKKRRDRINSSLTELKRLVPSAYEKQGSAKLEKAEILQLTVEHLKSL---QSKTLDS 162
            ||.|:.::|||||.|||.||.|| ||:.:..|.|  ||||.||:|:|||..::..   :::..:.
Mouse    26 RKARKPLVEKKRRARINESLQEL-RLLLAGTEVQ--AKLENAEVLELTVRRVQGALRGRAREREQ 87

  Fly   163 LSYDPQRVAMDYHIIGFRECAAEVARYLVTIEGMDIQDPLRLRLMSHLQYFVQQRE------LSA 221
            |    |..|.:....|:.:|..||..::.|.:.:|.  .:...|::||...:..||      |..
Mouse    88 L----QAEASERFAAGYIQCMHEVHTFVSTCQAIDA--TVSAELLNHLLESMPLREGSSFQDLLG 146

  Fly   222 KSCAS-PGG-----WSPAAPSSSGYQPNCAAAPYQSYAAPANPG------------AYVSSYPTL 268
            .|.|. |||     |.|            ..:|....::|..||            |.::..|
Mouse   147 DSLAGLPGGSGRSSWPP------------GGSPESPLSSPPGPGDDLCSDLEEIPEAELNRVP-- 197

  Fly   269 SASPSQQAQQLGGRTSVSR 287
            :..|...:..||..|:..|
Mouse   198 AEGPDLVSTSLGSLTAARR 216

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hey	NP_523657.1	HLH	100..156	CDD:238036	29/57 (51%)
Hey	NP_523657.1	ORANGE	172..218	CDD:128787	9/45 (20%)
Hes6	NP_062352.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31		3/4 (75%)
		bHLH_SF	24..81	CDD:412148	29/57 (51%)
		Hairy_orange	96..134	CDD:400076	9/39 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	146..209		14/76 (18%)
		WRPW motif	221..224
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810