DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hey and HES6

DIOPT Version :9

Sequence 1:	NP_523657.1	Gene:	Hey / 35764	FlyBaseID:	FBgn0027788	Length:	425	Species:	Drosophila melanogaster
Sequence 2:	NP_061115.2	Gene:	HES6 / 55502	HGNCID:	18254	Length:	224	Species:	Homo sapiens

Alignment Length:	208	Identity:	63/208 - (30%)
Similarity:	96/208 - (46%)	Gaps:	28/208 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 RKKRRGVIEKKRRDRINSSLTELKRLVPSAYEKQGSAKLEKAEILQLTVEHLKSL---QSKTLDS 162
            ||.|:.::|||||.|||.||.||:.|:..|   :..||||.||:|:|||..::.:   :::..:.
Human    26 RKARKPLVEKKRRARINESLQELRLLLAGA---EVQAKLENAEVLELTVRRVQGVLRGRAREREQ 87

  Fly   163 LSYDPQRVAMDYHIIGFRECAAEVARYLVTIEGMDIQDPLRLRLMSHLQYFVQQRE------LSA 221
            |    |..|.:....|:.:|..||..::.|.:.:|.  .:...|::||...:..||      |..
Human    88 L----QAEASERFAAGYIQCMHEVHTFVSTCQAIDA--TVAAELLNHLLESMPLREGSSFQDLLG 146

  Fly   222 KSCASPGGWSPAAPSSSGYQPNCAAAPYQSYAAPANPGAYVSSYPTLSASPSQQAQQ--LGGRTS 284
            .:.|.|    |.||..||:.  ...||.....:|..||..:.|  .|..:|..:..|  ..|...
Human   147 DALAGP----PRAPGRSGWP--AGGAPGSPIPSPPGPGDDLCS--DLEEAPEAELSQAPAEGPDL 203

  Fly   285 VSRTSGSAVTESL 297
            |....||..|..:
Human   204 VPAALGSLTTAQI 216

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hey	NP_523657.1	HLH	100..156	CDD:238036	27/57 (47%)
Hey	NP_523657.1	ORANGE	172..218	CDD:128787	9/45 (20%)
HES6	NP_061115.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31		3/4 (75%)
		HLH	23..75	CDD:238036	27/51 (53%)
		Hairy_orange	96..134	CDD:311465	9/39 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	147..205		17/65 (26%)
		WRPW motif	221..224
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810