DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hey and Helt

DIOPT Version :9

Sequence 1:	NP_523657.1	Gene:	Hey / 35764	FlyBaseID:	FBgn0027788	Length:	425	Species:	Drosophila melanogaster
Sequence 2:	XP_008769494.1	Gene:	Helt / 498633	RGDID:	1564073	Length:	241	Species:	Rattus norvegicus

Alignment Length:	205	Identity:	69/205 - (33%)
Similarity:	98/205 - (47%)	Gaps:	29/205 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 SCQLMSRKK---RRGVIEKKRRDRINSSLTELKRLVPSAYEKQGSAKLEKAEILQLTVEHLKSLQ 156
            |.:|..||:   ...||||:||||||..|.||.:.||.|..||.|.||||||||::||::|::|.
  Rat     2 SDRLKERKRTPVSHKVIEKRRRDRINRCLNELGKTVPMALAKQSSGKLEKAEILEMTVQYLRALH 66

  Fly   157 SKTLDSLSYDPQRVA--MDYHIIGFRECAAEVARYLVTIEGMDIQDPLRLRLMSHLQYFVQQREL 219
            |..........:.:|  .:|...|:.||...:..||.|:|.|:.:|....|:::.||   .:..|
  Rat    67 SADFPRGREKAELLAEFANYFHYGYHECMKNLVHYLTTVERMETKDTKYARILAFLQ---SKARL 128

  Fly   220 SAKSCASPGG---------WSPAAPSSSGYQPNCAAAPYQSYAAPAN----PGA-------YVSS 264
            .|:....|..         ..||.|...|:.|. .|..:...|.|.:    |||       |:||
  Rat   129 GAEPAFPPLSLPEPDFSYQLHPAGPEFPGHSPG-EATVFPQGATPGSFPWPPGAARSPALPYLSS 192

  Fly   265 YPTLSASPSQ 274
            ......:|:|
  Rat   193 ATVPLPTPAQ 202

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hey	NP_523657.1	HLH	100..156	CDD:238036	32/58 (55%)
Hey	NP_523657.1	ORANGE	172..218	CDD:128787	13/45 (29%)
Helt	XP_008769494.1	bHLH-O_HELT	14..69	CDD:381414	32/54 (59%)
Helt	XP_008769494.1	Hairy_orange	87..127	CDD:400076	12/42 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010