DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hey and HES1

DIOPT Version :9

Sequence 1:	NP_523657.1	Gene:	Hey / 35764	FlyBaseID:	FBgn0027788	Length:	425	Species:	Drosophila melanogaster
Sequence 2:	NP_005515.1	Gene:	HES1 / 3280	HGNCID:	5192	Length:	280	Species:	Homo sapiens

Alignment Length:	366	Identity:	91/366 - (24%)
Similarity:	139/366 - (37%)	Gaps:	114/366 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 DLYSEESSKE--------QISPSEPGSCQLMSRKKRRGVIEKKRRDRINSSLTELKRLVPSAYEK 133
            |:..:.||..        ..:|.:|.:.. ..||..:.::||:||.|||.||::||.|:..|.:|
Human     4 DIMEKNSSSPVAATPASVNTTPDKPKTAS-EHRKSSKPIMEKRRRARINESLSQLKTLILDALKK 67

  Fly   134 QGS--AKLEKAEILQLTVEHLKSLQ-SKTLDSLSYDPQRVAMDYHIIGFRECAAEVARYLVTIEG 195
            ..|  :|||||:||::||:||::|| ::...:||.||.  .:..:..||.||..||.|:|.|.||
Human    68 DSSRHSKLEKADILEMTVKHLRNLQRAQMTAALSTDPS--VLGKYRAGFSECMNEVTRFLSTCEG 130

  Fly   196 MDIQDPLRLRLMSHLQYFVQQ-----------RELSAKSCASPGGWSPAAPSSSGYQPNCAAAPY 249
            ::.:  :|.||:.||...:.|           ..|.|.....||   |..|..:.:.|.....|.
Human   131 VNTE--VRTRLLGHLANCMTQINAMTYPGQPHPALQAPPPPPPG---PGGPQHAPFAPPPPLVPI 190

  Fly   250 QSYAAPANPGAYVSSYPTLSASPSQQAQQLGGRTSVSRTSGSAVTESLPSHDLHSDSSSQQQQQQ 314
            ...|||...||...    |.:...:.|:..||
Human   191 PGGAAPPPGGAPCK----LGSQAGEAAKVFGG--------------------------------- 218

  Fly   315 QQQQQQQQQHQQQQHQQQQQRTQTTPQPTQQQHYTHDHSA-VHSEQQVPTYIELTNSNRPAAIGS 378
                                 .|..|.|..|..:...:.| .||...:|.|    .||...::|.
Human   219 ---------------------FQVVPAPDGQFAFLIPNGAFAHSGPVIPVY----TSNSGTSVGP 258

  Fly   379 DSLSYSAAPQYPVSGLPGQDYNNSSVLQYATPNGAKPYRPW 419
            :::|.|:.|......:                     :|||
Human   259 NAVSPSSGPSLTADSM---------------------WRPW 278

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hey	NP_523657.1	HLH	100..156	CDD:238036	28/57 (49%)
Hey	NP_523657.1	ORANGE	172..218	CDD:128787	17/56 (30%)
HES1	NP_005515.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44		7/40 (18%)
		bHLH-O_HES1_4	33..95	CDD:381465	30/61 (49%)
		Hairy_orange	110..148	CDD:400076	16/39 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	157..200		11/45 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	254..280		7/46 (15%)
		WRPW motif	275..278		1/2 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810