Protein Alignment Hey and HEY1

DIOPT Version :9

• Sequence 1: NP_523657.1
• Gene: Hey / 35764
• FlyBaseID: FBgn0027788
• Length: 425
• Species: Drosophila melanogaster
• Sequence 2: NP_001035798.1
• Gene: HEY1 / 23462
• HGNCID: 4880
• Length: 308
• Species: Homo sapiens
• Alignment Length: 404
• Identity: 134/404 - (33%)
• Similarity: 180/404 - (44%)
• Gaps: 129/404 - (31%)

  Fly    47 AHSNHSHGHSQGHSHGIGSLKRTL--SESDCDDLYSEESSKEQISPSEPGSCQLMSRKKRRGVIE 109
            ||..:|...|:        |..|:  .:...|:..:..|:...:||:.  |.|:::||:|||:||
Human     4 AHPEYSSSDSE--------LDETIEVEKESADENGNLSSALGSMSPTT--SSQILARKRRRGIIE 58

  Fly   110 KKRRDRINSSLTELKRLVPSAYEK----QGSAKLEKAEILQLTVEHLKSLQSKTLDSLSY-DPQR 169
            |:||||||:||:||:||||||:||    |||||||||||||:||:|||.|.  |.....| |...
Human    59 KRRRDRINNSLSELRRLVPSAFEKQVMEQGSAKLEKAEILQMTVDHLKMLH--TAGGKGYFDAHA 121

  Fly   170 VAMDYHIIGFRECAAEVARYLVTIEGMDIQDPLRLRLMSHLQYFVQQRELSAKSCASPG--GWSP 232
            :||||..:|||||.|||||||..|||:|..||||:||:|||..:..|||.::.:.|..|  .|.
Human   122 LAMDYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSHLNNYASQREAASGAHAGLGHIPWG- 185

  Fly   233 AAPSSSGYQPNCA---AAPYQSY------AAPANP---GAYVSSYPTLSASPSQQAQQLGGRTSV 285
               :..|:.|:.|   ..|...:      |:|..|   |...|::|...|..:..:..||....|
Human   186 ---TVFGHHPHIAHPLLLPQNGHGNAGTTASPTEPHHQGRLGSAHPEAPALRAPPSGSLGPVLPV 247

  Fly   286 SRTSGSAVTESLPSHDLHSDSSSQQQQQQQQQQQQQQQHQQQQHQQQQQRTQTTPQPTQQQHYTH 350
            . ||.|.::..|    |.|.:|.
Human   248 V-TSASKLSPPL----LSSVASL------------------------------------------ 265

  Fly   351 DHSAVHSEQQVPTYIELTNSNRPAAIGS------DSLSYSAAPQYPVSGLPGQDYNNSSVLQYAT 409
                               |..|.:.||      ::||.||..|                    .
Human   266 -------------------SAFPFSFGSFHLLSPNALSPSAPTQ--------------------A 291

  Fly   410 PNGAKPYRPWGAEM 423
            .|..|||||||.|:
Human   292 ANLGKPYRPWGTEI 305

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hey	NP_523657.1	HLH	100..156	CDD:238036	44/59 (75%)
		ORANGE	172..218	CDD:128787	29/45 (64%)
HEY1	NP_001035798.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..52		13/57 (23%)
		bHLH_SF	41..126	CDD:381792	53/88 (60%)
		ORANGE	124..170	CDD:128787	29/45 (64%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	200..238		8/37 (22%)
		YRPW motif	298..301		2/2 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	96	1.000	Domainoid score	I7334
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	168	1.000	Inparanoid score	I4154
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1201152at2759
OrthoFinder	1	1.000	-	-		FOG0002229
OrthoInspector	1	1.000	-	-		otm40692
orthoMCL	1	0.900	-	-		OOG6_108077
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1473
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.870