Protein Alignment Hey and Bhlhe40

DIOPT Version :9

• Sequence 1: NP_523657.1
• Gene: Hey / 35764
• FlyBaseID: FBgn0027788
• Length: 425
• Species: Drosophila melanogaster
• Sequence 2: NP_035628.1
• Gene: Bhlhe40 / 20893
• MGIID: 1097714
• Length: 411
• Species: Mus musculus
• Alignment Length: 337
• Identity: 84/337 - (24%)
• Similarity: 125/337 - (37%)
• Gaps: 91/337 - (27%)

  Fly    39 PPPQSHHSAHSNHSHGHSQGHSHGIGSLKRTLSESDCDDLYSEESSKEQISPSEPGSCQLMSRKK 103
            |||.....|         .|..||      .||..|...:|....|:..|..||...   .:.|.
Mouse     9 PPPTCLPKA---------PGLEHG------DLSGMDFAHMYQVYKSRRGIKRSEDSK---ETYKL 55

  Fly   104 RRGVIEKKRRDRINSSLTELKRLVPSAYEKQGSAKLEKAEILQLTVEHLKSL-------QSKTL- 160
            ...:||||||||||..:.:||.|:|...:......||||.:|:||::|:|:|       |.|.:
Mouse    56 PHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHVKALTNLIDQQQQKIIA 120

  Fly   161 -------DSLSYDPQRVAMDYHIIGFRECAAEVARYLVTIEGMDIQDPLRLRLMSHLQYFVQQRE 218
                   ..||........:....||:.||.||.:||...|  :.:|....:|::||...|.:.
Mouse   121 LQSGLQAGDLSGRNLEAGQEMFCSGFQTCAREVLQYLAKHE--NTRDLKSSQLVTHLHRVVSEL- 182

  Fly   219 LSAKSCASPGGWSPAA------PS-----SSGYQPNCAAAPYQSYAAPANPGAYVSSYPTLSASP 272
            |...:...|...:|.|      ||     |.|...||.....:::|                  |
Mouse   183 LQGGASRKPLDSAPKAVDLKEKPSFLAKGSEGPGKNCVPVIQRTFA------------------P 229

  Fly   273 SQQAQQLGGRTSVSRT-SGSAVTESLPSHDLHSD-------------------SSSQQQQQQQQQ 317
            |      ||..|.|.| :.|.....|...||.|:                   :..|:.::...:
Mouse   230 S------GGEQSGSDTDTDSGYGGELEKGDLRSEQPYFKSDHGRRFAVGERVSTIKQESEEPPTK 288

  Fly   318 QQQQQQHQQQQH 329
            :.:.|..:::.|
Mouse   289 KSRMQLSEEEGH 300

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hey	NP_523657.1	HLH	100..156	CDD:238036	25/62 (40%)
		ORANGE	172..218	CDD:128787	14/45 (31%)
Bhlhe40	NP_035628.1	Essential for interaction with ARNTL/BMAL1, E-box binding and repressor activity against the CLOCK-ARNTL/BMAL1 heterodimer. /evidence=ECO:0000250	1..139		44/147 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20		4/19 (21%)
		bHLH-O_DEC1	40..129	CDD:381592	30/91 (33%)
		Necessary for interaction with RXRA and repressor activity against RXRA. /evidence=ECO:0000250	75..79		2/3 (67%)
		ORANGE	140..184	CDD:128787	14/46 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	207..294		18/110 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810