DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hey and Hey2

DIOPT Version :9

Sequence 1:NP_523657.1 Gene:Hey / 35764 FlyBaseID:FBgn0027788 Length:425 Species:Drosophila melanogaster
Sequence 2:NP_038932.1 Gene:Hey2 / 15214 MGIID:1341884 Length:339 Species:Mus musculus


Alignment Length:396 Identity:138/396 - (34%)
Similarity:189/396 - (47%) Gaps:104/396 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    67 KRTLSESDCD---DLYSEE------SSKEQISPSEPGSCQLMSRKKRRGVIEKKRRDRINSSLTE 122
            :.|.||||.|   |:.||.      :|....|.|...:.|:|:||||||:|||:||||||:||:|
Mouse     6 EETTSESDLDETIDVGSENNYPGHATSSVMRSNSPTTTSQIMARKKRRGIIEKRRRDRINNSLSE 70

  Fly   123 LKRLVPSAYEKQGSAKLEKAEILQLTVEHLKSLQSKTLDSLSYDPQRVAMDYHIIGFRECAAEVA 187
            |:||||:|:|||||||||||||||:||:|||.||: |.....:|...:|.|:..||||||..|||
Mouse    71 LRRLVPTAFEKQGSAKLEKAEILQMTVDHLKMLQA-TGGKGYFDAHALATDFMSIGFRECLTEVA 134

  Fly   188 RYLVTIEGMDIQDPLRLRLMSHLQYFVQQRELSAKSCA--------SPGGWSPA---APSSSGYQ 241
            |||.::||:|..||||:||:|||.....|||.:..:.:        .|..|:.|   .|::. .|
Mouse   135 RYLSSVEGLDPSDPLRVRLVSHLSTCASQREAAVMTSSMAHHHHPLHPHHWAAAFHHLPTAL-LQ 198

  Fly   242 PN----CAAAPYQSYAAPANPGAYVSSYPTLSASPSQQAQQLGGRTSVSRTSGSAVTESLP--SH 300
            ||    ..:.|.:...:...|.|:.|:..|.:.:.:..|.::        .||..|...:|  |.
Mouse   199 PNGLHTSESTPCRLSTSSEVPSAHGSALLTATFAHADSALRM--------PSGGTVAPCVPPLST 255

  Fly   301 DLHSDSSSQQQQQQQQQQQQQQQHQQQQHQQQQQRTQTTPQPTQQQHYTHDHSAVHS-------- 357
            .|.|.|::                   .|......|                :|.||        
Mouse   256 SLLSLSAT-------------------VHAAAAAAT----------------AAAHSFPLSFAGA 285

  Fly   358 EQQVPTYIELTNSNRPAAIG-----SDSLSYSAAPQYPVSGLPGQDYNNSSVLQYATPNGAKPYR 417
            ...:|     :|:...||:.     |..||.|||               ||..|.:|....|||:
Mouse   286 FPMLP-----SNAAAAAAVAAATAISPPLSVSAA---------------SSPQQTSTGTNNKPYQ 330

  Fly   418 PWGAEM 423
            |||.|:
Mouse   331 PWGTEV 336

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HeyNP_523657.1 HLH 100..156 CDD:238036 44/55 (80%)
ORANGE 172..218 CDD:128787 26/45 (58%)
Hey2NP_038932.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..52 16/45 (36%)
Transcriptional repression and interaction with NCOR1 and SIN3A. /evidence=ECO:0000269|PubMed:11486045 47..116 49/69 (71%)
HLH 49..105 CDD:238036 45/55 (82%)
ORANGE 120..165 CDD:128787 26/44 (59%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 310..339 15/42 (36%)
YQPW motif 329..332 1/2 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 96 1.000 Domainoid score I7299
eggNOG 1 0.900 - - E1_KOG4304
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 161 1.000 Inparanoid score I4212
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1201152at2759
OrthoFinder 1 1.000 - - FOG0002229
OrthoInspector 1 1.000 - - otm42765
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR10985
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1473
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1110.930

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