DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hey and Hey1

DIOPT Version :9

Sequence 1:NP_523657.1 Gene:Hey / 35764 FlyBaseID:FBgn0027788 Length:425 Species:Drosophila melanogaster
Sequence 2:NP_034553.2 Gene:Hey1 / 15213 MGIID:1341800 Length:299 Species:Mus musculus


Alignment Length:386 Identity:129/386 - (33%)
Similarity:176/386 - (45%) Gaps:133/386 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    71 SESDCDDL--YSEESSKEQ-------ISPSEPGSCQLMSRKKRRGVIEKKRRDRINSSLTELKRL 126
            |:|:.|:.  ..:||:.|.       .|.|...|.|:::||:|||:|||:||||||:||:||:||
Mouse    11 SDSELDETIEVEKESADENGNLSSALCSMSPTTSSQVLARKRRRGIIEKRRRDRINNSLSELRRL 75

  Fly   127 VPSAYEKQGSAKLEKAEILQLTVEHLKSLQSKTLDSLSY-DPQRVAMDYHIIGFRECAAEVARYL 190
            ||||:|||||||||||||||:||:|||.|.  |.....| |...:||||..:|||||.|||||||
Mouse    76 VPSAFEKQGSAKLEKAEILQMTVDHLKMLH--TAGGKGYFDAHALAMDYRSLGFRECLAEVARYL 138

  Fly   191 VTIEGMDIQDPLRLRLMSHLQYFVQQRELSAKSCASPGG-----WSPAAPSSSGYQPNCA---AA 247
            ..|||:|..||||:||:|||..:..|||.::   .:.||     |.    |:.|:.|:.|   ..
Mouse   139 SIIEGLDASDPLRVRLVSHLNNYASQREAAS---GAHGGLGHIPWG----SAFGHHPHIAHPLLL 196

  Fly   248 PYQSY------AAPANP---GAYVSSYPTLSASPSQQAQQLGGRTSVSR--TSGSAVTESLPSHD 301
            |...:      |:|..|   |...|::|   .:|:.:|...||...|..  ||.|.::..|.|  
Mouse   197 PQNGHGNAGTAASPTEPHHQGRLASAHP---EAPALRAPPSGGLGPVLPVVTSASKLSPPLLS-- 256

  Fly   302 LHSDSSSQQQQQQQQQQQQQQQHQQQQHQQQQQRTQTTPQPTQQQHYTHDHSAVHSEQQVPTYIE 366
                                                                             
Mouse   257 ----------------------------------------------------------------- 256

  Fly   367 LTNSNRPAAIGSDSLSYSAAPQYPVSGLPGQDYNNSSVLQYATP----NGAKPYRPWGAEM 423
                           |.::...:|.|      :::..:|..:||    |..|||||||.|:
Mouse   257 ---------------SVASLSAFPFS------FSSFHLLSPSTPTQAANLGKPYRPWGTEI 296

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HeyNP_523657.1 HLH 100..156 CDD:238036 44/55 (80%)
ORANGE 172..218 CDD:128787 29/45 (64%)
Hey1NP_034553.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..53 12/41 (29%)
Transcriptional repression and interaction with NCOR1 and SIN3A. /evidence=ECO:0000250 48..117 48/70 (69%)
HLH 50..107 CDD:238036 45/58 (78%)
ORANGE 120..166 CDD:128787 29/45 (64%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 194..234 9/42 (21%)
YRPW motif 289..292 2/2 (100%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 96 1.000 Domainoid score I7299
eggNOG 1 0.900 - - E1_KOG4304
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 161 1.000 Inparanoid score I4212
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002229
OrthoInspector 1 1.000 - - otm42765
orthoMCL 1 0.900 - - OOG6_108077
Panther 1 1.100 - - O PTHR10985
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4600
SonicParanoid 1 1.000 - - X1473
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1211.850

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