DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hey and Hes2

DIOPT Version :9

Sequence 1:	NP_523657.1	Gene:	Hey / 35764	FlyBaseID:	FBgn0027788	Length:	425	Species:	Drosophila melanogaster
Sequence 2:	NP_001288734.1	Gene:	Hes2 / 15206	MGIID:	1098624	Length:	157	Species:	Mus musculus

Alignment Length:	164	Identity:	54/164 - (32%)
Similarity:	81/164 - (49%)	Gaps:	26/164 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 RKKRRGVIEKKRRDRINSSLTELKRLVPS--AYEKQGSAKLEKAEILQLTVEHLKSLQSKTLDSL 163
            ||..:.::||:||.|||.||::||.||..  ..|...|:|||||:||::||..|:...:....|.
Mouse    14 RKNLKPLLEKRRRARINESLSQLKGLVLPLLGAETSRSSKLEKADILEMTVRFLQEQPATLYSSA 78

  Fly   164 SYDPQRVAMDYHIIGFRECAAEVARYLVTIEGMDIQDP-LRLRLMSHLQYFVQQRELSAKSCASP 227
            :..|    ::.::.|:|.|.|.:||.|   ....:.:| :..||:.||    :||.:|..   ||
Mouse    79 APGP----LNSYLEGYRACLARLARVL---PACSVLEPAVSARLLEHL----RQRTVSDD---SP 129

  Fly   228 GGWSPAAPSSSGYQPNCAAAPYQSYAAPANPGAY 261
            ....|.||         |.||......|.:.|.:
Mouse   130 SLTLPPAP---------APAPSPPVPPPGSSGLW 154

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hey	NP_523657.1	HLH	100..156	CDD:238036	27/56 (48%)
Hey	NP_523657.1	ORANGE	172..218	CDD:128787	13/46 (28%)
Hes2	NP_001288734.1	bHLH_SF	10..73	CDD:381792	27/58 (47%)
		ORANGE	85..123	CDD:128787	13/44 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	124..157		11/43 (26%)
		WRPW motif	154..157		0/1 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810