DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hey and hey2

DIOPT Version :9

Sequence 1:	NP_523657.1	Gene:	Hey / 35764	FlyBaseID:	FBgn0027788	Length:	425	Species:	Drosophila melanogaster
Sequence 2:	XP_002936042.2	Gene:	hey2 / 100485328	XenbaseID:	XB-GENE-485923	Length:	394	Species:	Xenopus tropicalis

Alignment Length:	398	Identity:	139/398 - (34%)
Similarity:	184/398 - (46%)	Gaps:	104/398 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 SLKR----TLSESDCDDL--------YSEESSKEQISPSEP-GSCQLMSRKKRRGVIEKKRRDRI 116
            ::||    |.|:||.|:.        ||..||...|..:.| .:.|:|:||||||:|||:|||||
Frog    59 AMKRPCDDTSSDSDIDETIDVGSENNYSGHSSGSLIRSNSPTTTSQIMARKKRRGIIEKRRRDRI 123

  Fly   117 NSSLTELKRLVPSAYEKQGSAKLEKAEILQLTVEHLKSLQSKTLDSLSYDPQRVAMDYHIIGFRE 181
            |:||:||:||||:|:|||||||||||||||:||:|||.||: |.....:|...:|||:..|||||
Frog   124 NNSLSELRRLVPTAFEKQGSAKLEKAEILQMTVDHLKMLQA-TGGKGYFDAHALAMDFMSIGFRE 187

  Fly   182 CAAEVARYLVTIEGMDIQDPLRLRLMSHLQYFVQQRELSAKSCASPGGWSPAAPSSSGYQPNCAA 246
            |..||||||.::||:|..||||:||:|||.....|||..|.:       |..||......|:..|
Frog   188 CLTEVARYLGSVEGLDSSDPLRVRLVSHLSSCASQREAVAMT-------STVAPHQHSLHPHHWA 245

  Fly   247 APYQSYAAPANPGAYVSSYPTLSASPSQQAQQLGGRTSVSRTSGSAVTESLPSHDLHSDSSSQQQ 311
            |.:...                   |:...||.|..:|.:.|...:....|||
Frog   246 AAFHHL-------------------PAALLQQNGLSSSDNMTCRLSTATELPS------------ 279

  Fly   312 QQQQQQQQQQQQHQQQQHQQQQQRTQTTPQPTQQQHYTHDHSA--VHSEQQVPTYI-ELTNS--- 370
                            || .....|.|         :.|..:|  |.:...||..: .|:.|
Frog   280 ----------------QH-GSALLTAT---------FAHADAALRVPAAGSVPPGVPPLSTSLLS 318

  Fly   371 -----NRPAAIGSDSLSYSAAPQYPV--SGLPGQDYNNSSVLQYATP-------------NGAKP 415
                 :..||..:.|...|.|..:||  .|........|:....|:|             ..:||
Frog   319 LSATVHAAAAAAAQSFPLSFAGAFPVLPPGAAAAAMAASAATAIASPLSLTSSPRQAGGNVSSKP 383

  Fly   416 YRPWGAEM 423
            |||||.|:
Frog   384 YRPWGTEV 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hey	NP_523657.1	HLH	100..156	CDD:238036	44/55 (80%)
Hey	NP_523657.1	ORANGE	172..218	CDD:128787	27/45 (60%)
hey2	XP_002936042.2	bHLH-O_HEY2	99..180	CDD:381490	53/81 (65%)
hey2	XP_002936042.2	Hairy_orange	182..221	CDD:369405	24/38 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	96	1.000	Domainoid score	I7208
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	192	1.000	Inparanoid score	I3738
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1201152at2759
OrthoFinder	1	1.000	-	-		FOG0002229
OrthoInspector	1	1.000	-	-		otm47871
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1473
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060