Protein Alignment Dic3 and UCP2

DIOPT Version :10

• Sequence 1: NP_610344.2
• Gene: Dic3 / 35763
• FlyBaseID: FBgn0033248
• Length: 287
• Species: Drosophila melanogaster
• Sequence 2: NP_003346.2
• Gene: UCP2 / 7351
• HGNCID: 12518
• Length: 309
• Species: Homo sapiens
• Alignment Length: 278
• Identity: 88/278 - (31%)
• Similarity: 138/278 - (49%)
• Gaps: 19/278 - (6%)

  Fly    16 GVCAAIAVTGTHPIDLIKVQLQTQSQAD-----------RKTVGEILKGIHERSGILGFYNGISA 69
            |..|.||...|.|:|..||:||.|.::.           |..:|.||..: ...|....|||:.|
Human    21 GTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMV-RTEGPRSLYNGLVA 84

  Fly    70 SWFRQLTYTTTRFALYEAGKDYV----DTQKVSSKMALATFAGIVGGIVGVPGDVVTVRLQNDVK 130
            ...||:::.:.|..||::.|.:.    :...:.|::...:..|.:...|..|.|||.||.|...:
Human    85 GLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRLLAGSTTGALAVAVAQPTDVVKVRFQAQAR 149

  Fly   131 LPEEKRRNYKHVFDGLFRIYKEEGVSSLFRGTVPAVSRAVLLTIGTNAAYDQVKQMLKIATGAGE 195
            ....:|  |:...:....|.:|||...|::||.|.|:|..::.......||.:|..|..|....:
Human   150 AGGGRR--YQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELVTYDLIKDALLKANLMTD 212

  Fly   196 GVPLHFATSTIAGCIAVVITQPLDVIKTTFMNAQPGEFSGIGGAFLS-TAKQGPLAFYKGFIPAL 259
            .:|.||.::..||....||..|:||:||.:||:..|::|..|...|: ..|:||.||||||:|:.
Human   213 DLPCHFTSAFGAGFCTTVIASPVDVVKTRYMNSALGQYSSAGHCALTMLQKEGPRAFYKGFMPSF 277

  Fly   260 IRVSPNTIITFVLYEQAR 277
            :|:....::.||.|||.:
Human   278 LRLGSWNVVMFVTYEQLK 295

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dic3	NP_610344.2	Mito_carr	15..91	CDD:395101	27/85 (32%)
		Mito_carr	93..187	CDD:395101	25/93 (27%)
		Mito_carr	200..281	CDD:395101	33/79 (42%)
UCP2	NP_003346.2	Mito_carr	10..111	CDD:395101	27/90 (30%)
		Solcar 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00282	11..106		27/85 (32%)
		Important for interaction with long-chain fatty acids. /evidence=ECO:0000250|UniProtKB:P70406	16..63		13/41 (32%)
		transmembrane domain	17..34		5/12 (42%)
		transmembrane domain	78..100		7/21 (33%)
		Mito_carr	112..206	CDD:395101	26/95 (27%)
		Solcar 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00282	114..203		25/90 (28%)
		transmembrane domain	120..137		2/16 (13%)
		transmembrane domain	174..197		6/22 (27%)
		Solcar 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00282	212..297		34/84 (40%)
		transmembrane domain	216..235		6/18 (33%)
		Mito_carr	217..299	CDD:395101	33/79 (42%)
		purine nucleotide binding domain	264..273		6/8 (75%)
		transmembrane domain	269..291		9/21 (43%)
		Important for interaction with long-chain fatty acids. /evidence=ECO:0000250|UniProtKB:P70406	278..285		1/6 (17%)