Protein Alignment Dic3 and UCP1

DIOPT Version :10

• Sequence 1: NP_610344.2
• Gene: Dic3 / 35763
• FlyBaseID: FBgn0033248
• Length: 287
• Species: Drosophila melanogaster
• Sequence 2: NP_068605.1
• Gene: UCP1 / 7350
• HGNCID: 12517
• Length: 307
• Species: Homo sapiens
• Alignment Length: 278
• Identity: 80/278 - (28%)
• Similarity: 140/278 - (50%)
• Gaps: 21/278 - (7%)

  Fly    16 GVCAAIAVTGTHPIDLIKVQLQTQSQADRKTV----GEI--LKGIHERSGILGFYNGISASWFRQ 74
            |:.|.:|...|.|:|..||:||.|.:....:|    |.:  :..:.:..|.:..|:|:.|...||
Human    21 GIAACLADVITFPLDTAKVRLQVQGECPTSSVIRYKGVLGTITAVVKTEGRMKLYSGLPAGLQRQ 85

  Fly    75 LTYTTTRFALYEAGKDYVDTQK-----VSSKMALATFAGIVGGIVGVPGDVVTVRLQNDVKLPEE 134
            ::..:.|..||:..::::...|     :.||:......|.|...:|.|.:||.||||....|...
Human    86 ISSASLRIGLYDTVQEFLTAGKETAPSLGSKILAGLTTGGVAVFIGQPTEVVKVRLQAQSHLHGI 150

  Fly   135 KRRNYKHVFDGLFRIYK----EEGVSSLFRGTVPAVSRAVLLTIGTNAAYDQVKQMLKIATGAGE 195
            |.|     :.|.:..|:    .||::.|::||.|.:.|:|::.......||.:|:.........:
Human   151 KPR-----YTGTYNAYRIIATTEGLTGLWKGTTPNLMRSVIINCTELVTYDLMKEAFVKNNILAD 210

  Fly   196 GVPLHFATSTIAGCIAVVITQPLDVIKTTFMNAQPGEFSGIGGAFLST-AKQGPLAFYKGFIPAL 259
            .||.|..::.|||..|..::.|:||:||.|:|:.||::..:....:.. ..:||.||:||.:|:.
Human   211 DVPCHLVSALIAGFCATAMSSPVDVVKTRFINSPPGQYKSVPNCAMKVFTNEGPTAFFKGLVPSF 275

  Fly   260 IRVSPNTIITFVLYEQAR 277
            :|:....:|.||.:||.:
Human   276 LRLGSWNVIMFVCFEQLK 293

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dic3	NP_610344.2	Mito_carr	15..91	CDD:395101	22/80 (28%)
		Mito_carr	93..187	CDD:395101	29/102 (28%)
		Mito_carr	200..281	CDD:395101	27/79 (34%)
UCP1	NP_068605.1	Mito_carr	10..104	CDD:395101	22/82 (27%)
		Solcar 1	11..102		22/80 (28%)
		Mito_carr	111..206	CDD:395101	28/99 (28%)
		Solcar 2	111..201		28/94 (30%)
		Solcar 3	210..295		29/84 (35%)
		Mito_carr	215..300	CDD:395101	27/79 (34%)