DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dic3 and SCaMC

DIOPT Version :9

Sequence 1:	NP_610344.2	Gene:	Dic3 / 35763	FlyBaseID:	FBgn0033248	Length:	287	Species:	Drosophila melanogaster
Sequence 2:	NP_729802.1	Gene:	SCaMC / 39415	FlyBaseID:	FBgn0052103	Length:	583	Species:	Drosophila melanogaster

Alignment Length:	308	Identity:	83/308 - (26%)
Similarity:	131/308 - (42%)	Gaps:	51/308 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 WW----FGGVCAAIAVTGTHPIDLIKVQLQTQSQADRKTVGEILKGIHERSGILGFYNGISASWF 72
            ||    .||:..|::.|.|.|:|.|||.||.|:|  |..:.|.:..:....|....:.|...:..
  Fly   285 WWRHLVAGGIAGAVSRTCTAPLDRIKVYLQVQTQ--RMGISECMHIMLNEGGSRSMWRGNGINVL 347

  Fly    73 RQLTYTTTRFALYEAGKDYVDTQKVSSKMALAT--FAG-IVGGI---VGVPGDVVTVRLQNDVKL 131
            :....|..:||.||..|..:.....|.:|::..  :|| ..|||   :..|.:|:..||
  Fly   348 KIAPETAFKFAAYEQMKRLIRGDDGSRQMSIVERFYAGAAAGGISQTIIYPMEVLKTRL------ 406

  Fly   132 PEEKRR--NYKHVFDGLFRIYKEEGVSSLFRGTVPAVSRAVLLTIGTN-AAYDQVKQMLKIATGA 193
              ..||  .|..:.|...:|||:|||.|.:||.||.: ..:|...|.: |.|:.:|:.. ||...
  Fly   407 --ALRRTGQYAGIADAAVKIYKQEGVRSFYRGYVPNI-LGILPYAGIDLAVYETLKRRY-IANHD 467

  Fly   194 GEGVP---LHFATSTIAGCIAVVITQPLDVIKTTFMNAQPGE------------------FSG-- 235
            ....|   :..|..:.:..:..:.:.||.:::|. :.||..|                  .||
  Fly   468 NNEQPSFLVLLACGSTSSTLGQLCSYPLALVRTR-LQAQAAETIANQKRKTQIPLKSSDAHSGEE 531

  Fly   236 -IGGAFLSTAKQ-GPLAFYKGFIPALIRVSPNTIITFVLYEQARMRFG 281
             :.|.|....:| |....|:|..|..::|.|...|::|:||......|
  Fly   532 TMTGLFRKIVRQEGLTGLYRGITPNFLKVLPAVSISYVVYEYTSRALG 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dic3	NP_610344.2	PTZ00169	15..275	CDD:240302	79/293 (27%)
		Mito_carr	15..91	CDD:278578	24/75 (32%)
		Mito_carr	93..187	CDD:278578	31/102 (30%)
		Mito_carr	200..281	CDD:278578	22/102 (22%)
SCaMC	NP_729802.1	FRQ1	100..247	CDD:227455
		EFh	116..176	CDD:238008
		EFh	186..242	CDD:238008
		Mito_carr	285..370	CDD:278578	26/86 (30%)
		Mito_carr	375..463	CDD:278578	30/97 (31%)
		Mito_carr	470..581	CDD:278578	24/111 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45441963
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930