DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dic3 and SLC25A10

DIOPT Version :9

Sequence 1:	NP_610344.2	Gene:	Dic3 / 35763	FlyBaseID:	FBgn0033248	Length:	287	Species:	Drosophila melanogaster
Sequence 2:	NP_001257882.1	Gene:	SLC25A10 / 1468	HGNCID:	10980	Length:	406	Species:	Homo sapiens

Alignment Length:	175	Identity:	82/175 - (46%)
Similarity:	112/175 - (64%)	Gaps:	10/175 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 RLPRWWFGGVCAAIAVTGTHPIDLIKVQLQTQSQADRKTVGEILKGIHERSGILGFYNGISASWF 72
            |:.||:|||:.:..|...|||:||:||.||||.:...:..|..|: :....|||..|:|:|||..
Human     6 RVSRWYFGGLASCGAACCTHPLDLLKVHLQTQQEVKLRMTGMALR-VVRTDGILALYSGLSASLC 69

  Fly    73 RQLTYTTTRFALYEAGKDYVDTQKVS-------SKMALATFAGIVGGIVGVPGDVVTVRLQNDVK 130
            ||:||:.||||:||..:|.|  .|.|       .|:.|.:.:|:.||.||.|.|:|.||:|||||
Human    70 RQMTYSLTRFAIYETVRDRV--AKGSQGPLPFHEKVLLGSVSGLAGGFVGTPADLVNVRMQNDVK 132

  Fly   131 LPEEKRRNYKHVFDGLFRIYKEEGVSSLFRGTVPAVSRAVLLTIG 175
            ||:.:||||.|..|||:|:.:|||:..||.|...|.||..|:|:|
Human   133 LPQGQRRNYAHALDGLYRVAREEGLRRLFSGATMASSRGALVTVG 177

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dic3	NP_610344.2	PTZ00169	15..275	CDD:240302	78/168 (46%)
		Mito_carr	15..91	CDD:278578	34/75 (45%)
		Mito_carr	93..187	CDD:278578	42/90 (47%)
		Mito_carr	200..281	CDD:278578
SLC25A10	NP_001257882.1	Mito_carr	13..93	CDD:278578	37/82 (45%)
SLC25A10	NP_001257882.1	Mito_carr	95..179	CDD:278578	40/83 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158943
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0759
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S759
OMA	1	1.010	-	-		QHG51917
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104245
Panther	1	1.100	-	-	O	PTHR45618
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1953
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.660