DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nup44A and SEH1

DIOPT Version :9

Sequence 1:	NP_610343.1	Gene:	Nup44A / 35762	FlyBaseID:	FBgn0033247	Length:	354	Species:	Drosophila melanogaster
Sequence 2:	NP_011415.1	Gene:	SEH1 / 852778	SGDID:	S000003068	Length:	349	Species:	Saccharomyces cerevisiae

Alignment Length:	365	Identity:	113/365 - (30%)
Similarity:	189/365 - (51%)	Gaps:	69/365 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VEPIIADHKDVIHDVVFDYYGRRMATCSSDQTVKIW--DEDGQGKWNVTSSWKAHSGSIWRVSWA 66
            ::|..:.|.|::||||:|:|||.:|||||||.:|::  |:| ...|.::.||:||..||..:.||
Yeast     1 MQPFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKD-TSNWELSDSWRAHDSSIVAIDWA 64

  Fly    67 HPEFGQVVATCSFDRTASVWEEVIGEKVSSTNTPTRRWVRRTTLVDSRTSVTDVEFAPKYLGLLL 131
            .||:|:::|:.|:|:|..:|||...::..|    .|||.:..||.||:.|:..|:|||.:|||.|
Yeast    65 SPEYGRIIASASYDKTVKLWEEDPDQEECS----GRRWNKLCTLNDSKGSLYSVKFAPAHLGLKL 125

  Fly   132 ATASADGIIRIYEAPDIMNLSQWPVQHEI-------SNKLPLS-CLSWNTSTYMVTQLLAAGSDE 188
            |....|||:|:|:|.:..:|..|.:..|:       :|.|... ||||..|.:...:|..:..::
Yeast   126 ACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQ 190

  Fly   189 AAT----PTGKVFLFAYSENSRKCVKIDTVNDITDPVTDVAFAPNAGRTFHMLAVASKDLYI--- 246
            |..    ..||:.:.|.....:..::            .:::||:.||.:.::|...||..|
Yeast   191 AIIYQRGKDGKLHVAAKLPGHKSLIR------------SISWAPSIGRWYQLIATGCKDGRIRIF 243

  Fly   247 ----------------------------VNLRGVTDATDISKLDIQT-------IKFSEHNCPVW 276
                                        ::.:|.:|:....|.::|:       .:..:||..||
Yeast   244 KITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVW 308

  Fly   277 RVCWNMLATMLISTGDDGCVRLWRMNYNRQWRCAAVLKAE 316
            .|.||:..|:|.|.||||.||||:..|:.:::|.:|:.|:
Yeast   309 SVSWNLTGTILSSAGDDGKVRLWKATYSNEFKCMSVITAQ 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup44A	NP_610343.1	WD40	11..300	CDD:392136	107/340 (31%)
		WD40 repeat	16..55	CDD:293791	21/40 (53%)
		WD40 repeat	60..98	CDD:293791	14/37 (38%)
		WD40 repeat	118..159	CDD:293791	17/40 (43%)
		WD40 repeat	166..212	CDD:293791	10/50 (20%)
		WD40 repeat	221..267	CDD:293791	12/83 (14%)
		WD40 repeat	275..299	CDD:293791	14/23 (61%)
SEH1	NP_011415.1	WD40	7..332	CDD:421866	107/341 (31%)
		WD40 repeat	13..53	CDD:293791	21/40 (53%)
		WD40 repeat	58..105	CDD:293791	18/50 (36%)
		WD40 repeat	112..158	CDD:293791	18/45 (40%)
		WD40 repeat	165..207	CDD:293791	10/41 (24%)
		WD40 repeat	215..262	CDD:293791	8/58 (14%)
		WD40 repeat	307..346	CDD:293791	19/38 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344160
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2445
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68701
Inparanoid	1	1.050	191	1.000	Inparanoid score	I903
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55323
OrthoFinder	1	1.000	-	-		FOG0004075
OrthoInspector	1	1.000	-	-		oto99857
orthoMCL	1	0.900	-	-		OOG6_103638
Panther	1	1.100	-	-	LDO	PTHR11024
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1316
SonicParanoid	1	1.000	-	-		X3915
TreeFam	1	0.960	-	-
	14	13.790