DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nup44A and Seh1l

DIOPT Version :9

Sequence 1:	NP_610343.1	Gene:	Nup44A / 35762	FlyBaseID:	FBgn0033247	Length:	354	Species:	Drosophila melanogaster
Sequence 2:	NP_001347863.1	Gene:	Seh1l / 72124	MGIID:	1919374	Length:	417	Species:	Mus musculus

Alignment Length:	328	Identity:	189/328 - (57%)
Similarity:	246/328 - (75%)	Gaps:	14/328 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFDVEPIIADHKDVIHDVVFDYYGRRMATCSSDQTVKIWDEDGQGKWNVTSSWKAHSGSIWRVSW 65
            ||....|.|||||:||||.||::|||||||||||:||:||:...|.|:.|:|||.||||:|||:|
Mouse     1 MFVARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTW 65

  Fly    66 AHPEFGQVVATCSFDRTASVWEEVIGEKVSSTNTPTR---RWVRRTTLVDSRTSVTDVEFAPKYL 127
            ||||||||:|:|||||||:||||::||    :|...|   .||:||||||||||||||:||||::
Mouse    66 AHPEFGQVLASCSFDRTAAVWEEIVGE----SNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHM 126

  Fly   128 GLLLATASADGIIRIYEAPDIMNLSQWPVQHEISNKLPLSCLSWNTSTYMV-TQLLAAGSDEAA- 190
            ||:|||.|||||:|:|||||:||||||.:|||:|.||..||:|||.|:... ..::|.|||:::
Mouse   127 GLMLATCSADGIVRVYEAPDVMNLSQWSLQHEVSCKLCCSCISWNPSSSRAHPPMIAVGSDDSSP 191

  Fly   191 TPTGKVFLFAYSENSRKCVKIDTVNDITDPVTDVAFAPNAGRTFHMLAVASKDLYIVNL----RG 251
            ....||.:|.|:||:||..|.:|:..:||||.|:|||||.||:||:||||:||:.|..|    :.
Mouse   192 NSMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAVATKDVRIFTLKPLRKE 256

  Fly   252 VTDATDISKLDIQTI-KFSEHNCPVWRVCWNMLATMLISTGDDGCVRLWRMNYNRQWRCAAVLKA 315
            :|.:...:|.:|..: :|..||..||||.||:..|:|.|:|||||||||:.||...|:|..:||.
Mouse   257 LTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKANYMDNWKCTGILKG 321

  Fly   316 EGS 318
            .||
Mouse   322 NGS 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup44A	NP_610343.1	WD40	11..300	CDD:392136	175/298 (59%)
		WD40 repeat	16..55	CDD:293791	25/38 (66%)
		WD40 repeat	60..98	CDD:293791	26/37 (70%)
		WD40 repeat	118..159	CDD:293791	30/40 (75%)
		WD40 repeat	166..212	CDD:293791	19/47 (40%)
		WD40 repeat	221..267	CDD:293791	22/50 (44%)
		WD40 repeat	275..299	CDD:293791	16/23 (70%)
Seh1l	NP_001347863.1	WD 1	10..49		27/38 (71%)
		WD40	11..306	CDD:330360	175/298 (59%)
		WD40 repeat	15..55	CDD:293791	26/39 (67%)
		WD 2	55..96		31/44 (70%)
		WD40 repeat	61..111	CDD:293791	34/53 (64%)
		WD 3	111..152		32/40 (80%)
		WD40 repeat	116..149	CDD:293791	24/32 (75%)
		WD 4	160..210		21/49 (43%)
		WD40 repeat	166..212	CDD:293791	18/45 (40%)
		WD 5	217..258		22/40 (55%)
		WD40 repeat	222..267	CDD:293791	21/44 (48%)
		WD 6	276..315		23/38 (61%)
		WD40 repeat	281..320	CDD:293791	22/38 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838169
Domainoid	1	1.000	269	1.000	Domainoid score	I1835
eggNOG	1	0.900	-	-		E1_KOG2445
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68701
Inparanoid	1	1.050	398	1.000	Inparanoid score	I1935
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55323
OrthoDB	1	1.010	-	-		D375879at33208
OrthoFinder	1	1.000	-	-		FOG0004075
OrthoInspector	1	1.000	-	-		oto94117
orthoMCL	1	0.900	-	-		OOG6_103638
Panther	1	1.100	-	-	LDO	PTHR11024
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1316
SonicParanoid	1	1.000	-	-		X3915
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800