DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nup44A and Sec13

DIOPT Version :9

Sequence 1:	NP_610343.1	Gene:	Nup44A / 35762	FlyBaseID:	FBgn0033247	Length:	354	Species:	Drosophila melanogaster
Sequence 2:	NP_001287480.1	Gene:	Sec13 / 44437	FlyBaseID:	FBgn0024509	Length:	356	Species:	Drosophila melanogaster

Alignment Length:	327	Identity:	91/327 - (27%)
Similarity:	158/327 - (48%)	Gaps:	58/327 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VEPIIADHKDVIHDVVFDYYGRRMATCSSDQTVKIWDEDGQGKWNVTSSWKAHSGSIWRVSWAHP 68
            ::.|..:|:|::|....|:||..:||||||.:|:|:......|  ..:..|.|.|.:|:|:||||
  Fly     5 LQEIDTEHEDMVHHAALDFYGLLLATCSSDGSVRIFHSRKNNK--ALAELKGHQGPVWQVAWAHP 67

  Fly    69 EFGQVVATCSFDRTASVWEEVIGEKVSSTNTPTRRWVRRTTLVDSRTSVTDVEFAPKYLGLLLAT 133
            :||.::|:||:||...||:          :|..|.|.:.....:..:||..|:|||...||:||.
  Fly    68 KFGNILASCSYDRKVIVWK----------STTPRDWTKLYEYSNHDSSVNSVDFAPSEYGLVLAC 122

  Fly   134 ASADGIIR---------IYEAPDIMNLSQWPVQHEISNKLPLSCLSW--------------NTST 175
            ||:||.:.         :::|..|.|          ::.:.::.:||              .:.:
  Fly   123 ASSDGSVSVLTCNTEYGVWDAKKIPN----------AHTIGVNAISWCPAQAPDPAFDQRVTSRS 177

  Fly   176 YMVTQLLAAGSDEAATPTGKVFLFAYSENSRKCVKIDTVNDITDPVTDVAFAPNAGRTFHMLAVA 240
            ..|.:|::.|.|...    |:    :.|::.:.|:...:...:|.|.|||:||:.|.....:|.|
  Fly   178 AAVKRLVSGGCDNLV----KI----WREDNDRWVEEHRLEAHSDWVRDVAWAPSIGLPRSQIATA 234

  Fly   241 SKDLYIVNLRGVTDATDISKLDIQTIKFSEHNCPVWRVCWNMLATMLISTGDDGCVRLWRMNYNR 305
            |:|.:::......|.::.:...:.|  |.:   .||.:.|:....:|..||.|..|.||:.|...
  Fly   235 SQDRHVIVWSSNADLSEWTSTVLHT--FDD---AVWSISWSTTGNILAVTGGDNNVTLWKENTEG 294

  Fly   306 QW 307
            ||
  Fly   295 QW 296

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup44A	NP_610343.1	WD40	11..300	CDD:392136	86/311 (28%)
		WD40 repeat	16..55	CDD:293791	13/38 (34%)
		WD40 repeat	60..98	CDD:293791	15/37 (41%)
		WD40 repeat	118..159	CDD:293791	15/49 (31%)
		WD40 repeat	166..212	CDD:293791	9/59 (15%)
		WD40 repeat	221..267	CDD:293791	13/45 (29%)
		WD40 repeat	275..299	CDD:293791	8/23 (35%)
Sec13	NP_001287480.1	WD40	10..289	CDD:392136	86/313 (27%)
		WD40 repeat	60..101	CDD:293791	18/50 (36%)
		WD40 repeat	106..148	CDD:293791	15/41 (37%)
		WD40 repeat	155..207	CDD:293791	9/59 (15%)
		WD40 repeat	215..256	CDD:293791	12/40 (30%)
		WD40 repeat	264..290	CDD:293791	10/25 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450316
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D375879at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11024
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.950